Abstract • The meconium plug syndrome (MPS) is a common cause of low intestinal obstruction in newborn infants. Usually, it is benign and not associated with other intestinal dysfunction. We describe the cases of three infants in whom there was intestinal obstruction consistent with the MPS and in which cystic fibrosis (CF) was later documented. We suggest that there is an association between the MPS and CF, and that the condition of all infants with the MPS be evaluated for the possibility of both Hirschsprung's disease and CF. (Am J Dis Child 132:167-169, 1978) References 1. Clatworthy HW, Howard WHR, Lloyd J: The meconium plug syndrome . Surgery 39:131-142, 1956. 2. Ellis DG, Clatworthy HW: The meconium plug syndrome revisited . J Pediatr Surg 1:54-61, 1966.Crossref 3. Swischuk LE: Meconium plug syndrome: A cause of neonatal intestinal obstruction . Am J Roentgenol Rad Ther Nuc Med 103:339-346, 1968.Crossref 4. Mikity VG, Hodgman JE, Paciulli J: Meconium blockage syndrome . Radiology 88:740-744, 1967.Crossref 5. Gillis DA, Grantmyre EB: The meconium plug syndrome and Hirschsprung's disease . Can Med Assoc J 92:225-227, 1965. 6. Grossman H, Berdon WE, Baker DH: Gastrointestinal findings in cystic fibrosis . Am J Roentgenol Rad Ther Nuc Med 97:227-238, 1966.Crossref 7. Emery JL: Abnormalities in meconium of the foetus and newborn . Arch Dis Child 32:17-21, 1956.Crossref 8. Ching NPH, Ballinger WF: Perforation of the colon . Arch Surg 90:65-67, 1965.Crossref 9. Sokal MM, Koenigsberger MR, Rose JS, et al: Neonatal hypermagnesemia and the meconium plug syndrome . N Engl J Med 286:823-825, 1972.Crossref 10. Bruns T, Connell TR, Lacey JA, et al: Test strip meconium screening for cystic fibrosis . Am J Disease Child 131:71-73, 1977. 11. Poole CA, Rowe MI: Distal neonatal intestinal obstruction: The choice of contrast material . J Pediatr Surg 11:1011-1022, 1976.Crossref 12. Green MN, Shwachman H: Presumptive tests for cystic fibrosis based on serum protein in meconium . Pediatrics 41:989-992, 1968. 13. Dolan TF, Touloukian RJ: Familial meconium ileus not associated with cystic fibrosis . J Pediatr Surg 9:821-824, 1974.Crossref 14. Stephan U, Busch EW, Kollberg H, et al: Cystic fibrosis detection by means of a test-strip . Pediatrics 55:35-38, 1975.
American Journal of Diseases of Children – American Medical Association
Published: Feb 1, 1978