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CYSTEINE AS LOCAL PROTECTIVE TO HUMAN SKIN AGAINST X-RAYS

CYSTEINE AS LOCAL PROTECTIVE TO HUMAN SKIN AGAINST X-RAYS Abstract INVESTIGATORS long have sought means of protection against harm from radiation. The threat of mass injury in the atomic age accentuates all the more the urgent necessity for this research. This form of physical energy characteristically penetrates the deeper parts of the body, yet the skin by its exposed position remains the organ of primary attack. The accessibility of the skin as a target and the simplicity of retrieving it for study are advantages favoring its use for experimental purposes. The dermatologist naturally has an interest in any cutaneous study; but. because he so frequently resorts to the use of radiation therapy, he pays inordinate attention to investigations in this realm of biophysics. The literature covering this field of activity is becoming so large as to be beyond the compass of any except the specialist. A few samplings from it may be a shortcut to the point. Knowlton, Hempelmann, and References 1. Knowlton, N. P., Jr.; Hempelmann, L. H., and Hoffman, J. G.: The Effects of X-Rays on the Mitotic Activity of Mouse Epidermis , Science 107:625, 1948.Crossref 2. Griffith, J. Q., Jr.: Rutin: Therapy for Hemorrhagic Complications of Hypertension (William Hamlin Wilder Memorial Lecture) , Proc. Inst. Med. Chicago 16:434, 1947. 3. Griffith. J. Q., Jr.; Anthony, E.; Pendergrass, E. P., and Perryman, R.: Production of Increased Capillary Fragility in Rats Following Irradiation , Proc. Soc. Exper. Biol. & Med. 64:332, 1947. 4. Clark, W. G.; Uncapher, R. P., and Jordan, M. L.: Effect of Flavonoids (Vitamin P) on Mortality from Total Body Roentgen Irradiation , Science 108:629, 1948. 5. Sokoloff, V.; Redd, J. B., and Dutcher, R.: Vitamin P Protection Against Radiation , Science 112:112, 1950. 6. Barron, E. S. G.: Some Aspects of the Biological Action of Radiation , Declassified Document 484, United States Atomic Energy Commission, Technical Information Division, Oak Ridge, Tenn., 1946. 7. Barron, E. S. G.; Dickman, S.; Muntz, J. A., and Singer, T. P.: Studies on Mechanism of Action of Ionizing Radiations: I. Inhibition of Enzymes by X-Rays , J. Gen. Physiol. 32:537, 1949. 8. Patt, H. M.; Tyree, E. B.; Straube, R. L., and Smith, D. E.: Cysteine Protection Against X Irradiation , Science 110:213, 1949. 9. Forssberg, A.: On the Possibility of Protection the Living Organism Against Roentgen Rays by Chemical Means , Acta radiol. 33:296, 1950. 10. Grant, R.; Cornbleet, T., and Grossman, M. I.: Influence of Local Application of Adrenal Cortical Extract on Hair Growth in the Human , Arch. Dermat. & Syph. 62:717 ( (Nov.) ) 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

CYSTEINE AS LOCAL PROTECTIVE TO HUMAN SKIN AGAINST X-RAYS

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1951.01570100042005
Publisher site
See Article on Publisher Site

Abstract

Abstract INVESTIGATORS long have sought means of protection against harm from radiation. The threat of mass injury in the atomic age accentuates all the more the urgent necessity for this research. This form of physical energy characteristically penetrates the deeper parts of the body, yet the skin by its exposed position remains the organ of primary attack. The accessibility of the skin as a target and the simplicity of retrieving it for study are advantages favoring its use for experimental purposes. The dermatologist naturally has an interest in any cutaneous study; but. because he so frequently resorts to the use of radiation therapy, he pays inordinate attention to investigations in this realm of biophysics. The literature covering this field of activity is becoming so large as to be beyond the compass of any except the specialist. A few samplings from it may be a shortcut to the point. Knowlton, Hempelmann, and References 1. Knowlton, N. P., Jr.; Hempelmann, L. H., and Hoffman, J. G.: The Effects of X-Rays on the Mitotic Activity of Mouse Epidermis , Science 107:625, 1948.Crossref 2. Griffith, J. Q., Jr.: Rutin: Therapy for Hemorrhagic Complications of Hypertension (William Hamlin Wilder Memorial Lecture) , Proc. Inst. Med. Chicago 16:434, 1947. 3. Griffith. J. Q., Jr.; Anthony, E.; Pendergrass, E. P., and Perryman, R.: Production of Increased Capillary Fragility in Rats Following Irradiation , Proc. Soc. Exper. Biol. & Med. 64:332, 1947. 4. Clark, W. G.; Uncapher, R. P., and Jordan, M. L.: Effect of Flavonoids (Vitamin P) on Mortality from Total Body Roentgen Irradiation , Science 108:629, 1948. 5. Sokoloff, V.; Redd, J. B., and Dutcher, R.: Vitamin P Protection Against Radiation , Science 112:112, 1950. 6. Barron, E. S. G.: Some Aspects of the Biological Action of Radiation , Declassified Document 484, United States Atomic Energy Commission, Technical Information Division, Oak Ridge, Tenn., 1946. 7. Barron, E. S. G.; Dickman, S.; Muntz, J. A., and Singer, T. P.: Studies on Mechanism of Action of Ionizing Radiations: I. Inhibition of Enzymes by X-Rays , J. Gen. Physiol. 32:537, 1949. 8. Patt, H. M.; Tyree, E. B.; Straube, R. L., and Smith, D. E.: Cysteine Protection Against X Irradiation , Science 110:213, 1949. 9. Forssberg, A.: On the Possibility of Protection the Living Organism Against Roentgen Rays by Chemical Means , Acta radiol. 33:296, 1950. 10. Grant, R.; Cornbleet, T., and Grossman, M. I.: Influence of Local Application of Adrenal Cortical Extract on Hair Growth in the Human , Arch. Dermat. & Syph. 62:717 ( (Nov.) ) 1950.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Oct 1, 1951

References