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Cyclic Neutropenia

Cyclic Neutropenia Abstract Cyclic neutropenia is an unusual disease with numerous dermatologic manifestations. It was first reported in 1910 by Leale,1 and Löblowitz,2 who described the characteristic cyclic recurrence of oral ulcerations. They also noted the presence of an abnormal white blood cell count in their patients, but did not correlate this finding with the occurrence of mouth lesions. Thereafter there were numerous published reports of periodic oral ulcerations; however, the synchronous recurrence of neutropenia again was not investigated. It was not until 1930 that a definite association was established3 between the neutropenia and the mouth ulcerations, both of which recur along with fever, malaise, arthralgia, etc. at regular intervals of 21 days. There have been 32 additional case reports of cyclic neutropenia, with the majority appearing after 1946. Despite the extensive ulcerations of the lips, tongue, palate, gums, and buccal mucosa, as well as other cutaneous manifestations, dermatologists generally References 1. Leale, M.: Recurrent Furunculosis in an Infant Showing an Unusual Blood Picture , J.A.M.A. 54:1854-1855, 1910.Crossref 2. Löblowitz, J.: Ulcus neuroticum mucosae (Chronische Aphthen) , Arch. Derm. u Syph. 102: 191-206, 1910.Crossref 3. Rutledge, B. H.; Hansen-Prüss, O. C., and Thayer, W. S.: Recurrent Agranulocytosis , Bull. Johns Hopkins Hosp. 46:369-389, 1930. 4. Reimann, H. A.: Periodic Disease , A.M.A. Arch. Intern. Med. 92:494-506, 1953.Crossref 5. Reimann, H. A.: Periodic Disease , Medicine 30:219-245, 1949. 6. Löffler, W., and Maier, C.: Über einem Fall von Feltyschem Syndrom mit cyclisher Agranulocytose , Cardiologia 12:195-210, 1947-1948. 7. Erf, L. A., and Fry, K. E.: Primary Splenic Neutropenia , Amer. J. Clin. Path. 19:48-50, 1949. 8. Reznikoff, P.: Cyclic Neutropenia: A Case Study with Bone Marrow Findings Before and After Splenectomy , Trans. Ass. Amer. Physicians 59:276-281, 1946. 9. Reimann, H. A., and deBeradinis, C. T.: Periodic (Cyclic) Neutropenia: An Entity , Blood 4:1109-1116, 1949. 10. Owren, P. A.: Cyclic Agranulocytosis , Acta Med. Scand. 134:87-89, 1949.Crossref 11. Page, A. R., and Good, R. A.: Studies on Cyclic Neutropenia , A.M.A. J. Dis. Child. 94:623-667, 1957.Crossref 12. Sandella, J. F.: Cyclic Acute Agranulocytosis: Report of a Case with Improvement After Splenectomy , Ann. Intern. Med. 35:1365-1371, 1951.Crossref 13. Becker, F. T.; Coventry, W. D., and Ruura, J. L.: Recurrent Oral and Cutaneous Infections Associated with Cyclic Neutropenia , A.M.A. Arch. Derm. 80:731-741, 1959.Crossref 14. Cobet, R., and Schilling, V.: Periodischrezidivierende Neutropenie mit Monocytose: Das Krankheitsbild der periodischen Neutropenie oder cyclischen Agranulocytose , Folia Haemat. 70:286-303, 1951. 15. Vahlquist, B.: Cyclic Agranulocytosis: Report of a Case with a Short Survey of the Disease , Acta Med. Scand. , (Supp. 170) , pp. 531-542, 1946. 16. Borne, S.: Cyclic Neutropenia in an Infant , Pediatrics 3:70-78, 1949. 17. Fullerton, H. W., and Duguid, H. L. D.: A Case of Cyclic Agranulocytosis with Marked Improvement Following Splenectomy , Blood 4:269-277, 1949. 18. Reimann, H. A.: Personal communication to the author. 19. Monto, R. W.; Shaffer, H. C.; Brennan, M. J., and Rebuck, J. W.: Periodic Neutropenia Treated by Adrenocorticotrophic Hormone and Splenectomy: Report of a Case , New Engl. J. Med. 246:23, 893-896, 1952.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580150075012
Publisher site
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Abstract

Abstract Cyclic neutropenia is an unusual disease with numerous dermatologic manifestations. It was first reported in 1910 by Leale,1 and Löblowitz,2 who described the characteristic cyclic recurrence of oral ulcerations. They also noted the presence of an abnormal white blood cell count in their patients, but did not correlate this finding with the occurrence of mouth lesions. Thereafter there were numerous published reports of periodic oral ulcerations; however, the synchronous recurrence of neutropenia again was not investigated. It was not until 1930 that a definite association was established3 between the neutropenia and the mouth ulcerations, both of which recur along with fever, malaise, arthralgia, etc. at regular intervals of 21 days. There have been 32 additional case reports of cyclic neutropenia, with the majority appearing after 1946. Despite the extensive ulcerations of the lips, tongue, palate, gums, and buccal mucosa, as well as other cutaneous manifestations, dermatologists generally References 1. Leale, M.: Recurrent Furunculosis in an Infant Showing an Unusual Blood Picture , J.A.M.A. 54:1854-1855, 1910.Crossref 2. Löblowitz, J.: Ulcus neuroticum mucosae (Chronische Aphthen) , Arch. Derm. u Syph. 102: 191-206, 1910.Crossref 3. Rutledge, B. H.; Hansen-Prüss, O. C., and Thayer, W. S.: Recurrent Agranulocytosis , Bull. Johns Hopkins Hosp. 46:369-389, 1930. 4. Reimann, H. A.: Periodic Disease , A.M.A. Arch. Intern. Med. 92:494-506, 1953.Crossref 5. Reimann, H. A.: Periodic Disease , Medicine 30:219-245, 1949. 6. Löffler, W., and Maier, C.: Über einem Fall von Feltyschem Syndrom mit cyclisher Agranulocytose , Cardiologia 12:195-210, 1947-1948. 7. Erf, L. A., and Fry, K. E.: Primary Splenic Neutropenia , Amer. J. Clin. Path. 19:48-50, 1949. 8. Reznikoff, P.: Cyclic Neutropenia: A Case Study with Bone Marrow Findings Before and After Splenectomy , Trans. Ass. Amer. Physicians 59:276-281, 1946. 9. Reimann, H. A., and deBeradinis, C. T.: Periodic (Cyclic) Neutropenia: An Entity , Blood 4:1109-1116, 1949. 10. Owren, P. A.: Cyclic Agranulocytosis , Acta Med. Scand. 134:87-89, 1949.Crossref 11. Page, A. R., and Good, R. A.: Studies on Cyclic Neutropenia , A.M.A. J. Dis. Child. 94:623-667, 1957.Crossref 12. Sandella, J. F.: Cyclic Acute Agranulocytosis: Report of a Case with Improvement After Splenectomy , Ann. Intern. Med. 35:1365-1371, 1951.Crossref 13. Becker, F. T.; Coventry, W. D., and Ruura, J. L.: Recurrent Oral and Cutaneous Infections Associated with Cyclic Neutropenia , A.M.A. Arch. Derm. 80:731-741, 1959.Crossref 14. Cobet, R., and Schilling, V.: Periodischrezidivierende Neutropenie mit Monocytose: Das Krankheitsbild der periodischen Neutropenie oder cyclischen Agranulocytose , Folia Haemat. 70:286-303, 1951. 15. Vahlquist, B.: Cyclic Agranulocytosis: Report of a Case with a Short Survey of the Disease , Acta Med. Scand. , (Supp. 170) , pp. 531-542, 1946. 16. Borne, S.: Cyclic Neutropenia in an Infant , Pediatrics 3:70-78, 1949. 17. Fullerton, H. W., and Duguid, H. L. D.: A Case of Cyclic Agranulocytosis with Marked Improvement Following Splenectomy , Blood 4:269-277, 1949. 18. Reimann, H. A.: Personal communication to the author. 19. Monto, R. W.; Shaffer, H. C.; Brennan, M. J., and Rebuck, J. W.: Periodic Neutropenia Treated by Adrenocorticotrophic Hormone and Splenectomy: Report of a Case , New Engl. J. Med. 246:23, 893-896, 1952.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1961

References