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I. Schwartz, J. Thaysen (1956)
Excretion of sodium and potassium in human sweat.The Journal of clinical investigation, 35 1
J. Lieberman, F. Kellogg, B. Pruitt (1963)
EVALUATION OF THE SWEAT CHLORIDE ASSAY IN ADULTS: USE OF PILOCARPINE IONTOPHORESISThe American Journal of the Medical Sciences, 246
J. Bruce, G. Russell (1962)
Premenstrual tension. A study of weight changes and balances of water, sodium, and postassium.Lancet, 2 7250
R. Landau, E. Plotz, K. Lugibihl (1960)
Effect of pregnancy on the metabolic influence of administered progesterone.The Journal of clinical endocrinology and metabolism, 20
P.P. Siegenthaler (1965)
Contribution au probleme du diagnostic de la fibrose kystique du pancreas ou mucoviscidose chez l'adulteHelv Med Acta, 32
R. Landau, K. Lugibihl, D. Bergenstal, D. Dimick (1957)
The metabolic effects of progesterone in man: dose response relationships.The Journal of laboratory and clinical medicine, 50 4
E. Cotlove, H. Trantham, R. Bowman (1958)
An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples.The Journal of laboratory and clinical medicine, 51 3
G. Cage, R. Dobson (1965)
SODIUM SECRETION AND REABSORPTION IN THE HUMAN ECCRINE SWEAT GLAND.The Journal of clinical investigation, 44
P. Sant'Agnese (1959)
RECENT OBSERVATIONS ON PATHOGENESIS OF CYSTIC FIBROSIS OF THE PANCREASPediatrics, 24
M.N. Kalayci (1961)
The Influence of Chlorothiazide on Chloride Secretion by Sweat GlandsAmer J Dis Child, 102
W. Oliver, D. Watson (1964)
EFFECT OF SALT INTAKE ON SWEAT ELECTROLYTES IN CHILDREN.American journal of diseases of children, 107
L. Gibson, R. Cooke (1959)
A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis.Pediatrics, 23 3
Richard Landau, Delbert Bergenstal, K. Lugibihl, Marye. Kascht (1955)
The metabolic effects of progesterone in man.The Journal of clinical endocrinology and metabolism, 15 10
G. Thorn, K. Nelson, Doris Thorn (1938)
A STUDY OF THE MECHANISM OF EDEMA ASSOCIATED WITH MENSTRUATIONEndocrinology, 22
C. Lobeck, R. Barta, J. Mangos (1963)
Study of sweat in pitressin-resistant diabetes insipidus.The Journal of pediatrics, 62
D. Bergenstal, D. Dimick, R. Landau, K. Lugibihl, E. Rashid (1957)
The relationship of estrogen and of pituitary hormones to the metabolic effects of progesterone.The Journal of clinical endocrinology and metabolism, 17 2
J.W. Conn (1963)
Aldosteronism in ManJAMA, 183
J.W. Weber (1961)
Pitressin resistenter Diabetes insipidus, Therapie mit SalidiureticaHelv Paediat Acta, 16
J.F.G. Slegers (1963)
The Secretory Mechanism of the Eccrine Sweat GlandActa Physiol Pharmacol Neerl, 12
Abstract Spontaneous fluctuations in sweat electrolyte levels were studied in 57 women, including 21 mothers of children with cystic fibrosis (C/F mothers), and in nine men, to determine the effect of the menstrual cycle upon sweat salinity and to see if differences were apparent between C/F heterozygotes and controls. Sweat sodium and chloride concentrations, but not potassium, followed a cyclic pattern in 50% of the premenopausal women. The cyclic fluctuations appeared to follow the known hormonal pattern of the menstrual cycle with both "ovulatory" and "premenstrual" peaks of sweat salinity. Oral administration of a thiazide diuretic prevented or reversed the cyclic rise in sweat salinity, suggesting that the cyclic phenomenon is related to salt and water retention during the menstrual cycle. A single "sweat test" is inadequate for the detection of genetic heterozygotes for cystic fibrosis, because of the variability of sweat salinity. A greater percentage of C/F mothers had occasional sweat chloride determinations above 40 mEq/L than did the controls. Persistently high sweat salinity in an adult may be an indication of the genetic abnormality. References 1. Lieberman, J., and Kellogg, F.: Evaluation of the Sweat Chloride Assay in Adults: Use of Pilocarpine Iontophoresis , Amer J Med Sci 246:537-549, ( (Nov) ) 1963.Crossref 2. Gibson, L.E., and Cooke, R.E.: A Test for Concentration of Electrolytes in Sweat in Cystic Fibrosis of the Pancreas Utilizing Pilocarpine by Iontophoresis , Pediatrics 23:545-549 ( (March) ) 1959. 3. Cotlove, E.; Trantham, H.V.; and Bowman, R.L.: An Instrument and Method for Automatic Rapid, Accurate and Sensitive Titration of Chloride in Biological Samples , J Lab Clin Med 51:461-468 ( (March) ) 1958. 4. di Sant'Agnese, P.A.: Recent Observations on Pathogenesis of Cystic Fibrosis of the Pancreas , Pediatrics 24:313-321 ( (Aug) ) 1959. 5. Thorn, G.W.; Nelson, K.R.; and Thorn, D.W.: A Study of the Mechanism of Edema Associated With Menstruation , Endocrinology 22:155-163 ( (Feb) ) 1938.Crossref 6. Bruce, J., and Russell, G.F.M.: Premenstrual Tension: A Study of Weight Changes and Balances of Water, Sodium, and Potassium , Lancet 2:267-271 ( (Aug 11) ) 1962.Crossref 7. Landau, R.L., et al: The Metabolic Effects of Progesterone in Man , J Clin Endocr 15:1194-1215 ( (Oct) ) 1955.Crossref 8. Landau, R.L., et al: The Relationship of Estrogen and of Pituitary Hormones to the Metabolic Effects of Progesterone , J Clin Endocr 17:177-185 ( (Feb) ) 1957.Crossref 9. Landau, R.L., et al: The Metabolic Effects of Progesterone in Man: Dose Response Relationships , J Lab Clin Med 50:613-620 ( (Oct) ) 1957. 10. Landau, R.L.; Plotz, E.J.; and Lugibihl, K.: Effect of Pregnancy on the Metabolic Influence of Administered Progesterone , J Clin Endocr 20:1561-1567 ( (Dec) ) 1960.Crossref 11. Lobeck, C.C.; Barta, R.A.; and Mangos, J.A.: Study of Sweat in Pitressin Resistant Diabetes Insipidus , J Pediat 62:868-875 ( (June) ) 1963.Crossref 12. Weber, J.W., and Gautier, E.: Pitressin resistenter Diabetes insipidus, Therapie mit Salidiuretica , Helv Paediat Acta 16:565 ( (Dec) ) 1961. 13. Kalayci, M.N., and Gibbs, G.: The Influence of Chlorothiazide on Chloride Secretion by Sweat Glands , Amer J Dis Child 102:620 ( (Oct) ) 1961. 14. Conn, J.W.: Aldosteronism in Man , JAMA 183:775-781 ( (March 2) ) 1963.Crossref 15. Siegenthaler, P.P., and Haller, R. de: Contribution au probleme du diagnostic de la fibrose kystique du pancreas ou mucoviscidose chez l'adulte , Helv Med Acta 32:1-33, ( (April) ) 1965. 16. Oliver, W.I., and Watson, D.F.: Effect of Salt Intake on Sweat Electrolytes in Children , Amer J Dis Child 107:470-475, ( (May) ) 1964. 17. Schwartz, I.L., and Thaysen, J.H.: Excretion of Sodium and Potassium in Human Sweat , J Clin Invest 35:114-120, ( (Jan) ) 1956.Crossref 18. Cage, G.W., and Dobson, R.L.: Sodium Secretion and Reabsorption in the Human Eccrine Sweat Gland , J Clin Invest 44:1270-1276 ( (Aug) ) 1965.Crossref 19. Slegers, J.F.G.: The Secretory Mechanism of the Eccrine Sweat Gland , Acta Physiol Pharmacol Neerl 12:302 (No. (3) ) 1963.
JAMA – American Medical Association
Published: Feb 21, 1966
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