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Cyclic AMP Response to Epinephrine and Shock

Cyclic AMP Response to Epinephrine and Shock Abstract Hormonal regulation is fundamental to homeostasis, and the reponse in tissues is mediated by adenosine 3′:5′ = cyclic phosphate (cyclic AMP). Since circulating levels of catecholamines are elevated during hemorrhagic shock, experiments were carried out to study the effects of epinephrine and of shock on cyclic AMP levels of plasma and of the intestine, a particularly vulnerable organ in canine hemorrhagic shock. Epinephrine was given to normotensive dogs as a constant infusion (group 1) or as a single pulse (group 2). Sequential blood samples showed a marked increase in circulating cyclic AMP, especially in portal and hepatic venous blood. Little change was noted in the tissues. Hemorrhagic shock (group 3) induced a marked increase in plasma cyclic AMP, with a depletion of mucosal cyclic AMP and adenosine triphosphate (ATP). Pretreatment before shock with α-blockade (group 4) abolished the decrease in mucosal cyclic AMP and ATP, and reduced the increase in plasma cyclic AMP. References 1. Lillehei RC: The intestinal factor in irreversible hemorrhagic shock . Surgery 42:1043-1054, 1957. 2. Bounous G, Hampson LG, Gurd FN: Regional blood flow and oxygen consumption in experimental hemorrhagic shock . Arch Surg 87:340-354, 1963.Crossref 3. Bernard C: An Introduction to the Study of Experimental Medicine . HC Green (trans), New York, Dover Publications Inc, 1957. 4. Sutherland EW, Rall TW: The relation of adenosine-3′, 5′-phosphate and phosphorylase to the actions of catecholamines and other hormones . Pharmacol Rev 12:265-299, 1970. 5. Shafer DE, Lust WD, Sircar B, et al: Elevated concentration of adenosine-3′, 5′-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin . Proc Natl Acad Sci USA 67:851-856, 1970.Crossref 6. Kwan A, Chiu CJ, Mersereau W, et al: The role of intraluminal chyme and vasomotor response in the pathogenesis of non-occlusive intestinal infarcts . Ann Surg 179:877-882, 1974.Crossref 7. Gilman AG: A protein binding assay for adenosine 3′,5′-cyclic monophosphate . Proc Natl Acad Sci USA 67:305-312, 1970.Crossref 8. Forte JG, Adams PH, Davies RE: Acid secretion and phosphate metabolism in bullfrog gastric mucosa . Biochem Biophys Acta 104:25-38, 1965.Crossref 9. Hume D: Conference on shock . Fed Proc 20( (suppl 9) ):87-97, 1961. 10. Mellander S, Lewis DH: Effect of hemorrhagic shock on the reactivity of resistance and capacitance vessels and on capillary filtration transfer in cat skeletal muscle . Circ Res 13:105-118, 1963.Crossref 11. Baue A, Chaudry I, Mohammed S: Alterations in tissue responsiveness to insulin during shock. Read before the annual meeting of the Society of University Surgeons, St. Louis, 1974. 12. Rutenberg AM, Polgar P, Bell M, et al: Adenosine 3′-5′-monophosphate metabolism in the liver in experimental hemorrhagic shock . Surgery 74:660-665, 1973. 13. Wehmann RE, Blonde G, Steiner AG: Sources of cyclic nucleotides in plasma . J Clin Invest 53:173-179, 1974.Crossref 14. Egdahl RH: Hypertonic glucose and improved critical organ performance . Surgery 75:145-147, 1974. 15. Gross SD: quoted by Simeone FA: Shock, trauma and the surgeon . Ann Surg 158:759-774, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Cyclic AMP Response to Epinephrine and Shock

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360090086017
Publisher site
See Article on Publisher Site

Abstract

Abstract Hormonal regulation is fundamental to homeostasis, and the reponse in tissues is mediated by adenosine 3′:5′ = cyclic phosphate (cyclic AMP). Since circulating levels of catecholamines are elevated during hemorrhagic shock, experiments were carried out to study the effects of epinephrine and of shock on cyclic AMP levels of plasma and of the intestine, a particularly vulnerable organ in canine hemorrhagic shock. Epinephrine was given to normotensive dogs as a constant infusion (group 1) or as a single pulse (group 2). Sequential blood samples showed a marked increase in circulating cyclic AMP, especially in portal and hepatic venous blood. Little change was noted in the tissues. Hemorrhagic shock (group 3) induced a marked increase in plasma cyclic AMP, with a depletion of mucosal cyclic AMP and adenosine triphosphate (ATP). Pretreatment before shock with α-blockade (group 4) abolished the decrease in mucosal cyclic AMP and ATP, and reduced the increase in plasma cyclic AMP. References 1. Lillehei RC: The intestinal factor in irreversible hemorrhagic shock . Surgery 42:1043-1054, 1957. 2. Bounous G, Hampson LG, Gurd FN: Regional blood flow and oxygen consumption in experimental hemorrhagic shock . Arch Surg 87:340-354, 1963.Crossref 3. Bernard C: An Introduction to the Study of Experimental Medicine . HC Green (trans), New York, Dover Publications Inc, 1957. 4. Sutherland EW, Rall TW: The relation of adenosine-3′, 5′-phosphate and phosphorylase to the actions of catecholamines and other hormones . Pharmacol Rev 12:265-299, 1970. 5. Shafer DE, Lust WD, Sircar B, et al: Elevated concentration of adenosine-3′, 5′-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin . Proc Natl Acad Sci USA 67:851-856, 1970.Crossref 6. Kwan A, Chiu CJ, Mersereau W, et al: The role of intraluminal chyme and vasomotor response in the pathogenesis of non-occlusive intestinal infarcts . Ann Surg 179:877-882, 1974.Crossref 7. Gilman AG: A protein binding assay for adenosine 3′,5′-cyclic monophosphate . Proc Natl Acad Sci USA 67:305-312, 1970.Crossref 8. Forte JG, Adams PH, Davies RE: Acid secretion and phosphate metabolism in bullfrog gastric mucosa . Biochem Biophys Acta 104:25-38, 1965.Crossref 9. Hume D: Conference on shock . Fed Proc 20( (suppl 9) ):87-97, 1961. 10. Mellander S, Lewis DH: Effect of hemorrhagic shock on the reactivity of resistance and capacitance vessels and on capillary filtration transfer in cat skeletal muscle . Circ Res 13:105-118, 1963.Crossref 11. Baue A, Chaudry I, Mohammed S: Alterations in tissue responsiveness to insulin during shock. Read before the annual meeting of the Society of University Surgeons, St. Louis, 1974. 12. Rutenberg AM, Polgar P, Bell M, et al: Adenosine 3′-5′-monophosphate metabolism in the liver in experimental hemorrhagic shock . Surgery 74:660-665, 1973. 13. Wehmann RE, Blonde G, Steiner AG: Sources of cyclic nucleotides in plasma . J Clin Invest 53:173-179, 1974.Crossref 14. Egdahl RH: Hypertonic glucose and improved critical organ performance . Surgery 75:145-147, 1974. 15. Gross SD: quoted by Simeone FA: Shock, trauma and the surgeon . Ann Surg 158:759-774, 1963.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1975

References