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Cyclic Adenosine Monophosphate in Cerebral Cortex: Alterations Following Trauma

Cyclic Adenosine Monophosphate in Cerebral Cortex: Alterations Following Trauma Abstract Stab-wound injury produced a sevenfold elevation in cyclic adenosine monophosphate (AMP) in mouse brain within one minute. The increase in cyclic AMP in the brain was blocked by prior treatment of the animal by theophylline, chlorpromazine, trifluoperazine hydrochloride, and diphenhydramine hydrochloride. Neither dichloroisoproterenol, pronetalol, nor reserpine blocked the rise in cyclic AMP concentration due to injury. The results following administration of drugs suggest that the increases in cyclic AMP due to injury may be mediated by adenosine. Theophylline and phenothiazine derivatives have been shown previously to decrease adenosine-mediated increases in cyclic AMP in brain slices. The absence of any effect after administration of dichloroisoproterenol or pronetalol suggests that the increase in cyclic AMP after injury is not through catecholamine release. Hypothermia reduced the increase in cyclic AMP in injured brain after one minute. References 1. Sutherland EW, Rall TW: The relation of adenosine 3',5'-phosphate and phosphorylase to the action of catecholamines and other hormones . Pharmacol Rev 12:265-298, 1960. 2. Breckenridge BM: The measurement of cyclic adenylate in tissues . Proc Nat Acad Sci USA 52:1580-1586, 1964.Crossref 3. Kakiuchi S, Rall TW: The influence of chemical agents on the accumulation of adenosine 3',5'-phosphate in slices of rabbit cerebellum . Mol Pharmacol , 4:367-378, 1968. 4. Kakiuchi S, Rall TW: Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex . Mol Pharmacol 4:379-388, 1968. 5. Pauk GL, Reddy WJ: Measurement of adenosine 3',5'-monophosphate . Anal Biochem 21:298-307, 1967.Crossref 6. Weiss B, Costa E: Regional and subcellular distribution of adenyl cyclase and 3',5'-cyclic nucleotide phosphodiesterase in brain and pineal gland . Biochem Pharmacol 17:2107-2116, 1968.Crossref 7. Goldberg ND, Lust WD, O'Dea RF, et al: A role of cyclic nucleotides in brain metabolism , in Greengard P, Costa E (eds): Role of Cyclic AMP in Cell Function: Advances in Biochemical Psychopharmacology . New York, Raven Press, vol 3, 1970. 8. Kakiuchi S, Rall TW, McIlwain H: The effect of electrical stimulation upon the accumualtion of adenosine 3',5'-phosphate in isolated cerebral tissue . J Neurochem 16:485-491, 1969.Crossref 9. Watanabe H, Passonneau JV: The effect of trauma on cerebral glycogen and related metabolites and enzymes . Brain Res 66:147-159, 1974.Crossref 10. Brunner EA, Passonneau JV, Molstad C: The effect of volatile anesthetics on levels of metabolites and on metabolic rate in brain . J Neurochem 18:2301-2316, 1971.Crossref 11. Gilman AG: A protein binding assay for adenosine 3',5'-cyclic monophosphate . Proc Natl Acad Sci USA 67:305-312, 1970.Crossref 12. Ditzion BR, Paul MI, Pauk GL: Measurement of adenosine 3',5'-monophosphate (cyclic AMP) in brain . Pharmacology 3:25-31, 1970.Crossref 13. Uzunov P, Weiss B: Effects of phenothiazine tranquilizers on the cyclic 3',5'-adenosine monophosphate system of rat brain . Neuropharmacology 10:697-708, 1971.Crossref 14. Paul MI, Pauk GL, Ditzion BR: The effect of centrally acting drugs on the concentration of brain adenosine 3',5'-monophosphate . Pharmacology 3:148-154, 1970.Crossref 15. Schmidt MJ, Schmidt DE, Robison GA: Cyclic adenosine monophosphate in brain areas: Microwave irradiation as a means of tissue fixation . Science 173:1142-1143, 1971.Crossref 16. Klainer LM, Chi YM, Friedberg SL, et al: Adenyl cyclase: IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues . J Biol Chem 237:1239-2143, 1962. 17. Burkard WP: Catecholamine induced increase of cyclic adenosine 3',5'-monophosphate in rat brain in vivo . J Neurochem 19:2615-2619, 1972.Crossref 18. Sattin A, Rall TW: The effect of adenosine and adenine nucleotides on the cyclic adenosine 3',5'-phosphate content of guinea pig cerebral cortex slices . Mol Pharmacol 6:13-23, 1970. 19. Palmer GC, Robison GA, Manian A, et al: Modification by psychotropic drugs of the cyclic AMP response to norepinephrine (NE) in rat brain . Pharmacologist 12:256, 1970. 20. Weiss B: Factors affecting adenyl cyclase activity and its sensitivity to biogenic amines , in Blum JJ (ed): Biogenic Amines as Physiological Regulators . Englewood Cliffs, NJ, Prentice Hall Inc, 1970, pp 35-73. 21. Michenfelder JD, Theye RA: The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation . Anesthesiology 33:430-439, 1970.Crossref 22. Michenfelder JD, Theye RA: Hypothermia: Effect on canine brain and whole-body metabolism . Anesthesiology 29:1107-1112, 1968.Crossref 23. Little DM: Hypothermia . Anesthesiology 20:842-877, 1959.Crossref 24. Oja SS, Sarajas HSS: Cerebral energy metabolism in young rats during anesthesia and hypothermia . Ann Med Exp Biol Fenn 49:29-34, 1971. 25. Lust WD, Passonneau JV: Influence of certain drugs on cyclic nucleotide levels in mouse brain following electro-convulsive shock . Trans Am Soc Neurochem 4:115, 1973. 26. Sattin A: Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines . J Neurochem 18:1087-1096, 1971.Crossref 27. Shimizu H, Creveling CR, Daly JW: Stimulated formation of adenosine 3',5'-cyclic monophosphate in cerebral cortical slices . Eur J Pharmacol 17:240-252, 1972.Crossref 28. Collins RC, Posner JV, Plum F: Cerebral energy metabolism during electroshock seizures in mice . Am J Physiol 218:943-950, 1970. 29. Babskaya YE, Pogosova AV: Vliyanie gipotermii i narkoza na pronitsaemost' i utilizatsiyu aminokislot v protsesse sinteza belkov organov i tkanei . Ukr Biokhim Zh 41:52-59, 1969. 30. Sarajas HSS, Putkonen PTS: Central nervous and visceral reaction pattern in rabbits warming up from deep hypothermia . Ann Acad Sci Fenn 4:144-149, 1968. 31. Shimizu H, Creveling CR, Daly JW: Stimulated formation of adenosine 3',5'-cyclic phosphate in cerebral cortex: Synergism between electrical activity and biogenic amines . Proc Natl Acad Sci USA 65:1033-1040, 1970.Crossref 32. Shimizu H, Daly JW: Formation of cyclic adenosine 3',5'-monophosphate from adenosine in brain slices . Biochim Biophys Acta 222:465-473, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Cyclic Adenosine Monophosphate in Cerebral Cortex: Alterations Following Trauma

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1975.00490450061008
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Abstract

Abstract Stab-wound injury produced a sevenfold elevation in cyclic adenosine monophosphate (AMP) in mouse brain within one minute. The increase in cyclic AMP in the brain was blocked by prior treatment of the animal by theophylline, chlorpromazine, trifluoperazine hydrochloride, and diphenhydramine hydrochloride. Neither dichloroisoproterenol, pronetalol, nor reserpine blocked the rise in cyclic AMP concentration due to injury. The results following administration of drugs suggest that the increases in cyclic AMP due to injury may be mediated by adenosine. Theophylline and phenothiazine derivatives have been shown previously to decrease adenosine-mediated increases in cyclic AMP in brain slices. The absence of any effect after administration of dichloroisoproterenol or pronetalol suggests that the increase in cyclic AMP after injury is not through catecholamine release. Hypothermia reduced the increase in cyclic AMP in injured brain after one minute. References 1. Sutherland EW, Rall TW: The relation of adenosine 3',5'-phosphate and phosphorylase to the action of catecholamines and other hormones . Pharmacol Rev 12:265-298, 1960. 2. Breckenridge BM: The measurement of cyclic adenylate in tissues . Proc Nat Acad Sci USA 52:1580-1586, 1964.Crossref 3. Kakiuchi S, Rall TW: The influence of chemical agents on the accumulation of adenosine 3',5'-phosphate in slices of rabbit cerebellum . Mol Pharmacol , 4:367-378, 1968. 4. Kakiuchi S, Rall TW: Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex . Mol Pharmacol 4:379-388, 1968. 5. Pauk GL, Reddy WJ: Measurement of adenosine 3',5'-monophosphate . Anal Biochem 21:298-307, 1967.Crossref 6. Weiss B, Costa E: Regional and subcellular distribution of adenyl cyclase and 3',5'-cyclic nucleotide phosphodiesterase in brain and pineal gland . Biochem Pharmacol 17:2107-2116, 1968.Crossref 7. Goldberg ND, Lust WD, O'Dea RF, et al: A role of cyclic nucleotides in brain metabolism , in Greengard P, Costa E (eds): Role of Cyclic AMP in Cell Function: Advances in Biochemical Psychopharmacology . New York, Raven Press, vol 3, 1970. 8. Kakiuchi S, Rall TW, McIlwain H: The effect of electrical stimulation upon the accumualtion of adenosine 3',5'-phosphate in isolated cerebral tissue . J Neurochem 16:485-491, 1969.Crossref 9. Watanabe H, Passonneau JV: The effect of trauma on cerebral glycogen and related metabolites and enzymes . Brain Res 66:147-159, 1974.Crossref 10. Brunner EA, Passonneau JV, Molstad C: The effect of volatile anesthetics on levels of metabolites and on metabolic rate in brain . J Neurochem 18:2301-2316, 1971.Crossref 11. Gilman AG: A protein binding assay for adenosine 3',5'-cyclic monophosphate . Proc Natl Acad Sci USA 67:305-312, 1970.Crossref 12. Ditzion BR, Paul MI, Pauk GL: Measurement of adenosine 3',5'-monophosphate (cyclic AMP) in brain . Pharmacology 3:25-31, 1970.Crossref 13. Uzunov P, Weiss B: Effects of phenothiazine tranquilizers on the cyclic 3',5'-adenosine monophosphate system of rat brain . Neuropharmacology 10:697-708, 1971.Crossref 14. Paul MI, Pauk GL, Ditzion BR: The effect of centrally acting drugs on the concentration of brain adenosine 3',5'-monophosphate . Pharmacology 3:148-154, 1970.Crossref 15. Schmidt MJ, Schmidt DE, Robison GA: Cyclic adenosine monophosphate in brain areas: Microwave irradiation as a means of tissue fixation . Science 173:1142-1143, 1971.Crossref 16. Klainer LM, Chi YM, Friedberg SL, et al: Adenyl cyclase: IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues . J Biol Chem 237:1239-2143, 1962. 17. Burkard WP: Catecholamine induced increase of cyclic adenosine 3',5'-monophosphate in rat brain in vivo . J Neurochem 19:2615-2619, 1972.Crossref 18. Sattin A, Rall TW: The effect of adenosine and adenine nucleotides on the cyclic adenosine 3',5'-phosphate content of guinea pig cerebral cortex slices . Mol Pharmacol 6:13-23, 1970. 19. Palmer GC, Robison GA, Manian A, et al: Modification by psychotropic drugs of the cyclic AMP response to norepinephrine (NE) in rat brain . Pharmacologist 12:256, 1970. 20. Weiss B: Factors affecting adenyl cyclase activity and its sensitivity to biogenic amines , in Blum JJ (ed): Biogenic Amines as Physiological Regulators . Englewood Cliffs, NJ, Prentice Hall Inc, 1970, pp 35-73. 21. Michenfelder JD, Theye RA: The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation . Anesthesiology 33:430-439, 1970.Crossref 22. Michenfelder JD, Theye RA: Hypothermia: Effect on canine brain and whole-body metabolism . Anesthesiology 29:1107-1112, 1968.Crossref 23. Little DM: Hypothermia . Anesthesiology 20:842-877, 1959.Crossref 24. Oja SS, Sarajas HSS: Cerebral energy metabolism in young rats during anesthesia and hypothermia . Ann Med Exp Biol Fenn 49:29-34, 1971. 25. Lust WD, Passonneau JV: Influence of certain drugs on cyclic nucleotide levels in mouse brain following electro-convulsive shock . Trans Am Soc Neurochem 4:115, 1973. 26. Sattin A: Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines . J Neurochem 18:1087-1096, 1971.Crossref 27. Shimizu H, Creveling CR, Daly JW: Stimulated formation of adenosine 3',5'-cyclic monophosphate in cerebral cortical slices . Eur J Pharmacol 17:240-252, 1972.Crossref 28. Collins RC, Posner JV, Plum F: Cerebral energy metabolism during electroshock seizures in mice . Am J Physiol 218:943-950, 1970. 29. Babskaya YE, Pogosova AV: Vliyanie gipotermii i narkoza na pronitsaemost' i utilizatsiyu aminokislot v protsesse sinteza belkov organov i tkanei . Ukr Biokhim Zh 41:52-59, 1969. 30. Sarajas HSS, Putkonen PTS: Central nervous and visceral reaction pattern in rabbits warming up from deep hypothermia . Ann Acad Sci Fenn 4:144-149, 1968. 31. Shimizu H, Creveling CR, Daly JW: Stimulated formation of adenosine 3',5'-cyclic phosphate in cerebral cortex: Synergism between electrical activity and biogenic amines . Proc Natl Acad Sci USA 65:1033-1040, 1970.Crossref 32. Shimizu H, Daly JW: Formation of cyclic adenosine 3',5'-monophosphate from adenosine in brain slices . Biochim Biophys Acta 222:465-473, 1970.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1975

References