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Cyclic Activity In Sleep of Macaca Mulatta

Cyclic Activity In Sleep of Macaca Mulatta Abstract Introduction RECENT observations have demonstrated in adult man a basic physiologic periodicity during sleep of 80-90 minutes,1-3 in the adult cat 20-25 minutes4-6 and in the adult rat 13 minutes.7 These cycles consist of alternation of a high voltage slow wave stage with a low voltage fast frequency cortical electroencephalographic sleep stage, the latter occupying 15%-25% of sleep time. Characteristic alterations in a number of autonomic and somatic motor functions have been found to correlate with the EEG pattern.8,9 In this study observations of the periodic EEG and behavioral sleep patterns of Macaca mulatta are reported. Method Five M mulatta monkeys, (5-8 lb) had cortical and subcortical electrodes implanted under anesthesia for chronic recordings. The cortical electrodes (three-eighth inch silver discs) were placed on the dura mater through burr holes in the skull and cemented in place with acrylic central cement. Bipolar stainless steel electrodes References 1. Aserinsky, E., and Kleitman, N.: Two Types of Ocular Motility During Sleep , J Appl Physiol 8:1-10, 1955. 2. Dement, W., and Kleitman, N.: Cyclic Variations in EEG During Sleep and Their Relation to Eye Movements, Body Motility and Dreaming , Clin Neurophysiol 9:673, 1957.Crossref 3. Kleitman, N.: Sleep and Wakefulness , University of Chicago Press, 1964. 4. Dement, W.: Occurrence of Low Voltage, Fast Electroencephalogram Patterns During Behavioral Sleep in Cat, Clin , Neurophysiol 10:291-296, 1958. 5. Hubel, D. H.: Electrocorticograms in Cats During Natural Sleep , Arch Ital Biol 98:171-181, 1960. 6. Jouvet, M.; Dechaume, J.; and Michel, F.: Etude des mechanismes du sommeil physiologique , Lyon Med 38:1-39, 1960. 7. Roldan, E.; Weiss, T.; and Fifkova, E.: Excitability Changes During Sleep Cycle of Rat , Clin Neurophysiol 15:775-785, 1963.Crossref 8. Snyder, F., et al: Changes in Respiration, Heart Rate and Systolic Blood Pressure in Human Sleep , J Appl Physiol 19:417-422, 1964. 9. Berger, R. J.: Tonus of Extrinsic Laryngeal Muscles During Sleep and Dreaming , Science 134:840, 1961.Crossref 10. Sheatz, G.: Electrical Stimulation of the Brain , Daniel E. Sheer (ed.), Austin, Tex: University of Texas Press, 1961, pp 45-50. 11. Snider, R. S., and Lee, J. C.: Stereotaxic Atlas of Monkey Brain (Macaca Mulatta) , Chicago, Ill.: University of Chicago Press, 1961. 12. Weitzman, E. D.: Note on EEG and Eye Movements During Behavioral Sleep in Monkeys , Clin Neurophysiol 13:790-794, 1961.Crossref 13. McNemar, Q.: Psychological Statistics , ed 3, New York: Wiley Press, 1962. 14. Adey, W. R.; Kado, T.; and Rhodes, J. M.: Sleep: Cortical and Subcortical Recordings in Chimpanzee , Science 141:932-933, 1963.Crossref 15. Lissak, K., et al: Study of Hippocampal Function in Waking and Sleeping Animal With Chronically Implanted Electrodes , Acta Physiol Pharmacol Neerl 6:451-459, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1965.00460290019003
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction RECENT observations have demonstrated in adult man a basic physiologic periodicity during sleep of 80-90 minutes,1-3 in the adult cat 20-25 minutes4-6 and in the adult rat 13 minutes.7 These cycles consist of alternation of a high voltage slow wave stage with a low voltage fast frequency cortical electroencephalographic sleep stage, the latter occupying 15%-25% of sleep time. Characteristic alterations in a number of autonomic and somatic motor functions have been found to correlate with the EEG pattern.8,9 In this study observations of the periodic EEG and behavioral sleep patterns of Macaca mulatta are reported. Method Five M mulatta monkeys, (5-8 lb) had cortical and subcortical electrodes implanted under anesthesia for chronic recordings. The cortical electrodes (three-eighth inch silver discs) were placed on the dura mater through burr holes in the skull and cemented in place with acrylic central cement. Bipolar stainless steel electrodes References 1. Aserinsky, E., and Kleitman, N.: Two Types of Ocular Motility During Sleep , J Appl Physiol 8:1-10, 1955. 2. Dement, W., and Kleitman, N.: Cyclic Variations in EEG During Sleep and Their Relation to Eye Movements, Body Motility and Dreaming , Clin Neurophysiol 9:673, 1957.Crossref 3. Kleitman, N.: Sleep and Wakefulness , University of Chicago Press, 1964. 4. Dement, W.: Occurrence of Low Voltage, Fast Electroencephalogram Patterns During Behavioral Sleep in Cat, Clin , Neurophysiol 10:291-296, 1958. 5. Hubel, D. H.: Electrocorticograms in Cats During Natural Sleep , Arch Ital Biol 98:171-181, 1960. 6. Jouvet, M.; Dechaume, J.; and Michel, F.: Etude des mechanismes du sommeil physiologique , Lyon Med 38:1-39, 1960. 7. Roldan, E.; Weiss, T.; and Fifkova, E.: Excitability Changes During Sleep Cycle of Rat , Clin Neurophysiol 15:775-785, 1963.Crossref 8. Snyder, F., et al: Changes in Respiration, Heart Rate and Systolic Blood Pressure in Human Sleep , J Appl Physiol 19:417-422, 1964. 9. Berger, R. J.: Tonus of Extrinsic Laryngeal Muscles During Sleep and Dreaming , Science 134:840, 1961.Crossref 10. Sheatz, G.: Electrical Stimulation of the Brain , Daniel E. Sheer (ed.), Austin, Tex: University of Texas Press, 1961, pp 45-50. 11. Snider, R. S., and Lee, J. C.: Stereotaxic Atlas of Monkey Brain (Macaca Mulatta) , Chicago, Ill.: University of Chicago Press, 1961. 12. Weitzman, E. D.: Note on EEG and Eye Movements During Behavioral Sleep in Monkeys , Clin Neurophysiol 13:790-794, 1961.Crossref 13. McNemar, Q.: Psychological Statistics , ed 3, New York: Wiley Press, 1962. 14. Adey, W. R.; Kado, T.; and Rhodes, J. M.: Sleep: Cortical and Subcortical Recordings in Chimpanzee , Science 141:932-933, 1963.Crossref 15. Lissak, K., et al: Study of Hippocampal Function in Waking and Sleeping Animal With Chronically Implanted Electrodes , Acta Physiol Pharmacol Neerl 6:451-459, 1957.

Journal

Archives of NeurologyAmerican Medical Association

Published: May 1, 1965

References