Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cyanide Poisoning— A Challenge

Cyanide Poisoning— A Challenge Abstract It is now over 40 years since Chen and his associates1 published a classic report on the treatment of cyanide poisoning using dogs as the animal model. Until the current report of Graham et al in this issue (see p 1051), this therapeutic regimen was virtually unchallenged as the definitive treatment for cyanide poisoning in humans. The presentation by Graham and his colleagues certainly must be considered an assault upon the sacred cow. They raise a number of provocative issues and have the temerity to challenge the application of the therapeutic combination of sodium nitrate and sodium thiosulfate. The basic lesion in cyanide poisoning is the product of a very tight combination between the cyanide ion and the ferric ion of cytochrome oxidase. The affinity between cytochrome oxidase and cyanide is very tight,2 and inactivates this key respiratory enzyme. The rationale behind the use of sodium nitrate was References 1. Chen KK, Rose CL, Chowes GHA: Comparative values of several antidotes in cyanide poisoning . Am J Med Sci 188:767-781, 1934.Crossref 2. Albaum H, Tepperman J, Bodanski 0: A spectrophotometric study of the competition of methemoglobin and cytochrome oxidase for cyanide in vitro . J Biol Chem 163:641-647, 1946. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Cyanide Poisoning— A Challenge

Berlin, Cheston
Archives of Internal Medicine , Volume 137 (8) – Aug 1, 1977
Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/cyanide-poisoning-a-challenge-8nlW5lY6Nr

References (2)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1977.03630200003003
Publisher site
See Article on Publisher Site

Abstract

Abstract It is now over 40 years since Chen and his associates1 published a classic report on the treatment of cyanide poisoning using dogs as the animal model. Until the current report of Graham et al in this issue (see p 1051), this therapeutic regimen was virtually unchallenged as the definitive treatment for cyanide poisoning in humans. The presentation by Graham and his colleagues certainly must be considered an assault upon the sacred cow. They raise a number of provocative issues and have the temerity to challenge the application of the therapeutic combination of sodium nitrate and sodium thiosulfate. The basic lesion in cyanide poisoning is the product of a very tight combination between the cyanide ion and the ferric ion of cytochrome oxidase. The affinity between cytochrome oxidase and cyanide is very tight,2 and inactivates this key respiratory enzyme. The rationale behind the use of sodium nitrate was References 1. Chen KK, Rose CL, Chowes GHA: Comparative values of several antidotes in cyanide poisoning . Am J Med Sci 188:767-781, 1934.Crossref 2. Albaum H, Tepperman J, Bodanski 0: A spectrophotometric study of the competition of methemoglobin and cytochrome oxidase for cyanide in vitro . J Biol Chem 163:641-647, 1946.

Journal

Archives of Internal Medicine – American Medical Association

Published: Aug 1, 1977

There are no references for this article.