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Cutaneous T-Cell Lymphoma Associated With the Acquired Immunodeficiency Syndrome

Cutaneous T-Cell Lymphoma Associated With the Acquired Immunodeficiency Syndrome Abstract • Four cases of T-cell lymphoma occurring in the setting of the acquired immunodeficiency syndrome (AIDS) have been reported previously. We describe a 46-year-old man with AIDS in whom a cutaneous T-cell lymphoma with lymph node involvement developed. Immunohistochemical staining of the skin revealed the lymphoid infiltrate to be CD3+, CD4-, CD8-, and T-cell antigen receptor alpha/beta positive. Coinfection with human T-cell lymphotropic virus type I was not detected by polymerase chain reaction. Human immunodeficiency virus infection may have contributed to the development of this patient's lymphoma. This case represents the rare occurrence of cutaneous T-cell lymphoma and AIDS. (Arch Dermatol. 1991;127:1020-1022) References 1. Ziegler JL, Beckstead JA, Volberding PA, et al. Non-Hodgkin's lymphoma in 90 homosexual men: relationship to generalized lymphadenopathy and the acquired immunodeficiency syndrome . N Engl J Med. 1984;311:565-570.Crossref 2. Knowles DM, Chamulak GA, Subar M, et al. Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS): The New York University Medical Center Experience with 105 patients (1981-1986) . Ann Intern Med. 1988;108:744-753.Crossref 3. Kaplan LD, Abrams DI, Feigal E, et al. AIDS-associated non-Hodgkins lymphoma in San Francisco . JAMA. 1989;261:719-724.Crossref 4. Nasar SA, Brynes RK, Garrison CP, Chan WC. Peripheral T-cell lymphoma in a patient with acquired immune deficiency syndrome . Cancer. 1988;61:947-951.Crossref 5. Shibata D, Brynes RK, Rabinowitz A, et al. Human T-cell lymphotropic virus type I (HTLV-I)—associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) . Ann Intern Med. 1989;111:871-875.Crossref 6. Parker SC, Fenton DA, McGibbon DH. Homme rouge and the acquired immunodeficiency syndrome . N Engl J Med. 1989;321: 906-907. 7. Lanier LL, Federspiel NA, Ruitenberg JJ, et al. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes: a CD3-associated disulfide-linked gamma chain heterodimer . J Exp Med. 1987;165:1076-1094.Crossref 8. Borst J, Van de Griend RJ, Van Oostveen JW, et al. A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes . Nature. 1987;325:683-688.Crossref 9. Groh V, Fabbi M, Maziarz R, et al. `Double-negtive' (CD4— CD8—) lymphocytes bearing T cell receptor (TCR) alpha/beta in normal human skin . FASEB J. 1989;3:A4859. 10. Picker LJ, Brenner MB, Weiss LM, et al. Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas . Am J Pathol. 1987;129:434-440. 11. Margolick JB, Carey V, Munoz A, et al. Development of antibodies to HIV-1 Is associated with an increase in circulating CD3+CD4—CD8— lymphocytes . Clin Immunol Immunopathol. 1989;51:348-361.Crossref 12. Wright DN, Robert NP, Ledford DK, et al. Serum IgE human immunodeficiency virus infection . J Allergy Clin Immunol. 1990;85:445-452.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous T-Cell Lymphoma Associated With the Acquired Immunodeficiency Syndrome

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680060094011
Publisher site
See Article on Publisher Site

Abstract

Abstract • Four cases of T-cell lymphoma occurring in the setting of the acquired immunodeficiency syndrome (AIDS) have been reported previously. We describe a 46-year-old man with AIDS in whom a cutaneous T-cell lymphoma with lymph node involvement developed. Immunohistochemical staining of the skin revealed the lymphoid infiltrate to be CD3+, CD4-, CD8-, and T-cell antigen receptor alpha/beta positive. Coinfection with human T-cell lymphotropic virus type I was not detected by polymerase chain reaction. Human immunodeficiency virus infection may have contributed to the development of this patient's lymphoma. This case represents the rare occurrence of cutaneous T-cell lymphoma and AIDS. (Arch Dermatol. 1991;127:1020-1022) References 1. Ziegler JL, Beckstead JA, Volberding PA, et al. Non-Hodgkin's lymphoma in 90 homosexual men: relationship to generalized lymphadenopathy and the acquired immunodeficiency syndrome . N Engl J Med. 1984;311:565-570.Crossref 2. Knowles DM, Chamulak GA, Subar M, et al. Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS): The New York University Medical Center Experience with 105 patients (1981-1986) . Ann Intern Med. 1988;108:744-753.Crossref 3. Kaplan LD, Abrams DI, Feigal E, et al. AIDS-associated non-Hodgkins lymphoma in San Francisco . JAMA. 1989;261:719-724.Crossref 4. Nasar SA, Brynes RK, Garrison CP, Chan WC. Peripheral T-cell lymphoma in a patient with acquired immune deficiency syndrome . Cancer. 1988;61:947-951.Crossref 5. Shibata D, Brynes RK, Rabinowitz A, et al. Human T-cell lymphotropic virus type I (HTLV-I)—associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) . Ann Intern Med. 1989;111:871-875.Crossref 6. Parker SC, Fenton DA, McGibbon DH. Homme rouge and the acquired immunodeficiency syndrome . N Engl J Med. 1989;321: 906-907. 7. Lanier LL, Federspiel NA, Ruitenberg JJ, et al. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes: a CD3-associated disulfide-linked gamma chain heterodimer . J Exp Med. 1987;165:1076-1094.Crossref 8. Borst J, Van de Griend RJ, Van Oostveen JW, et al. A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes . Nature. 1987;325:683-688.Crossref 9. Groh V, Fabbi M, Maziarz R, et al. `Double-negtive' (CD4— CD8—) lymphocytes bearing T cell receptor (TCR) alpha/beta in normal human skin . FASEB J. 1989;3:A4859. 10. Picker LJ, Brenner MB, Weiss LM, et al. Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas . Am J Pathol. 1987;129:434-440. 11. Margolick JB, Carey V, Munoz A, et al. Development of antibodies to HIV-1 Is associated with an increase in circulating CD3+CD4—CD8— lymphocytes . Clin Immunol Immunopathol. 1989;51:348-361.Crossref 12. Wright DN, Robert NP, Ledford DK, et al. Serum IgE human immunodeficiency virus infection . J Allergy Clin Immunol. 1990;85:445-452.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1991

References