Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Cutaneous Signs of Lymphomatoid Granulomatosis

Cutaneous Signs of Lymphomatoid Granulomatosis Abstract • A retrospective review of 47 cases of lymphomatoid granulomatosis encountered between 1977 and 1990 revealed that 24 patients had skin involvement. Clinical and histologic features were noted. The dominant and most characteristic cutaneous finding was scattered nodules. Other cutaneous changes included eroded and crusted lesions, facial edema, papules, and folliculitis-like eruptions. The nodular skin lesions most often had an angiocentric and angiodestructive dense, polymorphous, lymphohistiocytic infiltrate in the dermis and fat. A minority of the cases had a lymphoma cutis type of infiltrate. Immunophenotypic analysis showed a mixed population of T cells, with helper T cells (CD4+) predominant. Our results emphasize the usefulness of the clinical and histologic examination of the skin in lymphomatoid granulomatosis. The histologic pattern of lymphomatoid granulomatosis was seen in the skin in more than half of the biopsy specimens. (Arch Dermatol. 1991;127:1693-1698) References 1. Liebow AA, Carrington CRB, Friedman PJ. Lymphomatoid granulomatosis . Hum Pathol. 1972;3:457-558.Crossref 2. Jaffe ES. Post-thymic lymphoid neoplasia . J Major Probl Pathol. 1985;16:218-248. 3. Weis JW, Winter MW, Phyliky RL, Banks PM. Peripheral T-cell lymphomas: histologic, immunohistologic, and clinical characterization . Mayo Clin Proc. 1986;61:411-426.Crossref 4. Colby TV, Carrington CB. Lymphoreticular tumors and infiltrates of the lung . Pathol Annu. 1983;18(pt (1) ):27-70. 5. Pisani RJ, DeRemee RA. Clinical implications of the histopathologic diagnosis of pulmonary lymphomatoid granulomatosis . Mayo Clin Proc. 1990;65:151-163.Crossref 6. DeRemee RA, Weiland LH, McDonald TJ. Polymorphic reticulosis, lymphomatoid granulomatosis: two diseases or one? Mayo Clin Proc. 1978;53:634-640. 7. Letendre L. Treatment of lymphomatoid granulomatosis: old and new perspectives . Semin Respir Med. 1989;10:178-181.Crossref 8. Katzenstein A-LA, Carrington CB, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases . Cancer . 1979;43:360-373.Crossref 9. James WD, Odom RB, Katzenstein A-LA. Cutaneous manifestations of lymphomatoid granulomatosis: report of 44 cases and a review of the literature . Arch Dermatol. 1981;117:196-202.Crossref 10. Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA, Nichols PW. Lymphomatoid granulomatosis: a clinicopathologic study of 42 patients . Pathology . 1986;18:283-288.Crossref 11. Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid granulomatosis: prospective clinical and therapeutic experience over 10 years . N Engl J Med. 1982;306:68-74.Crossref 12. Kessler S, Lund HZ, Leonard DD. Cutaneous lesions of lymphomatoid granulomatosis: comparison with lymphomatoid papulosis . Am J Dermatopathol. 1981;3:115-127.Crossref 13. Jambrosic J, From L, Assaad DA, Lipa M, Sibbald RG, Walter JB. Lymphomatoid granulomatosis . J Am Acad Dermatol. 1987;17:621-631.Crossref 14. Gaulard P, Henni T, Marolleau J-P, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis: evidence for a monoclonal T-cell lymphoproliferative disorder . Cancer . 1988;62:705-710.Crossref 15. Lippman SM, Grogan TM, Spier CM, et al. Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma . Cancer . 1987;59:936-939.Crossref 16. Bleiweiss IJ, Strauchen JA. Lymphomatoid granulomatosis of the lung: report of a case and gene rearrangement studies . Hum Pathol. 1988;19:1109-1112.Crossref 17. Lipford EH Jr, Margolick JB, Longo DL, Fauci AS, Jaffe ES. Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations . Blood . 1988;72:1674-1681. 18. Minase T, Ogasawara M, Kikuchi T, et al. Lymphomatoid granulomatosis: light microscopic, electron microscopic and immunohistochemical study . Acta Pathol Jpn. 1985;35:711-721. 19. Chan JKC, Ng CS, Lau WH, Lo STH. Most nasal/nasopharyngeal lymphomas are peripheral T-cell neoplasms . Am J Surg Pathol. 1987;11:418-429.Crossref 20. Petras RE, Tubbs RR, Gephardt GN, Sebek BA, Golish JA, Weick JK. T lymphocyte proliferation in lymphomatoid granulomatosis . Cleve Clin Q. 1985;52:137-146.Crossref 21. Whittaker S, Foroni L, Luzzatto L, et al. Lymphomatoid granulomatosis: evidence of a clonal T-cell origin and an association with lethal midline granuloma . Q J Med. 1988;68:645-655. 22. Donner LR, Dobin S, Harrington D, Bassion S, Rappaport ES, Peterson RF. Angiocentric immunoproliferative lesion (lymphomatoid granulomatosis): a cytogenetic, immunophenotypic, and genotypic study . Cancer . 1990;65:249-254.Crossref 23. Mittal K, Neri A, Feiner H, Schinella R, Alfonso F. Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome: evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement . Cancer . 1990;65:1345-1349.Crossref 24. Troussard X, Galateau F, Gaulard P, et al. Lymphomatoid granulomatosis in a patient with acute myeloblastic leukemia in remission . Cancer . 1990;65:107-111.Crossref 25. Katzenstein A-LA, Asken FB. Surgical Pathology of Non-Neoplastic Lung Disease . 2nd ed. Philadelphia, Pa: WB Saunders Co; 1990:306. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous Signs of Lymphomatoid Granulomatosis

Loading next page...
 
/lp/american-medical-association/cutaneous-signs-of-lymphomatoid-granulomatosis-1rEC0r3vvf
Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680100093011
Publisher site
See Article on Publisher Site

Abstract

Abstract • A retrospective review of 47 cases of lymphomatoid granulomatosis encountered between 1977 and 1990 revealed that 24 patients had skin involvement. Clinical and histologic features were noted. The dominant and most characteristic cutaneous finding was scattered nodules. Other cutaneous changes included eroded and crusted lesions, facial edema, papules, and folliculitis-like eruptions. The nodular skin lesions most often had an angiocentric and angiodestructive dense, polymorphous, lymphohistiocytic infiltrate in the dermis and fat. A minority of the cases had a lymphoma cutis type of infiltrate. Immunophenotypic analysis showed a mixed population of T cells, with helper T cells (CD4+) predominant. Our results emphasize the usefulness of the clinical and histologic examination of the skin in lymphomatoid granulomatosis. The histologic pattern of lymphomatoid granulomatosis was seen in the skin in more than half of the biopsy specimens. (Arch Dermatol. 1991;127:1693-1698) References 1. Liebow AA, Carrington CRB, Friedman PJ. Lymphomatoid granulomatosis . Hum Pathol. 1972;3:457-558.Crossref 2. Jaffe ES. Post-thymic lymphoid neoplasia . J Major Probl Pathol. 1985;16:218-248. 3. Weis JW, Winter MW, Phyliky RL, Banks PM. Peripheral T-cell lymphomas: histologic, immunohistologic, and clinical characterization . Mayo Clin Proc. 1986;61:411-426.Crossref 4. Colby TV, Carrington CB. Lymphoreticular tumors and infiltrates of the lung . Pathol Annu. 1983;18(pt (1) ):27-70. 5. Pisani RJ, DeRemee RA. Clinical implications of the histopathologic diagnosis of pulmonary lymphomatoid granulomatosis . Mayo Clin Proc. 1990;65:151-163.Crossref 6. DeRemee RA, Weiland LH, McDonald TJ. Polymorphic reticulosis, lymphomatoid granulomatosis: two diseases or one? Mayo Clin Proc. 1978;53:634-640. 7. Letendre L. Treatment of lymphomatoid granulomatosis: old and new perspectives . Semin Respir Med. 1989;10:178-181.Crossref 8. Katzenstein A-LA, Carrington CB, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases . Cancer . 1979;43:360-373.Crossref 9. James WD, Odom RB, Katzenstein A-LA. Cutaneous manifestations of lymphomatoid granulomatosis: report of 44 cases and a review of the literature . Arch Dermatol. 1981;117:196-202.Crossref 10. Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA, Nichols PW. Lymphomatoid granulomatosis: a clinicopathologic study of 42 patients . Pathology . 1986;18:283-288.Crossref 11. Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid granulomatosis: prospective clinical and therapeutic experience over 10 years . N Engl J Med. 1982;306:68-74.Crossref 12. Kessler S, Lund HZ, Leonard DD. Cutaneous lesions of lymphomatoid granulomatosis: comparison with lymphomatoid papulosis . Am J Dermatopathol. 1981;3:115-127.Crossref 13. Jambrosic J, From L, Assaad DA, Lipa M, Sibbald RG, Walter JB. Lymphomatoid granulomatosis . J Am Acad Dermatol. 1987;17:621-631.Crossref 14. Gaulard P, Henni T, Marolleau J-P, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis: evidence for a monoclonal T-cell lymphoproliferative disorder . Cancer . 1988;62:705-710.Crossref 15. Lippman SM, Grogan TM, Spier CM, et al. Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma . Cancer . 1987;59:936-939.Crossref 16. Bleiweiss IJ, Strauchen JA. Lymphomatoid granulomatosis of the lung: report of a case and gene rearrangement studies . Hum Pathol. 1988;19:1109-1112.Crossref 17. Lipford EH Jr, Margolick JB, Longo DL, Fauci AS, Jaffe ES. Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations . Blood . 1988;72:1674-1681. 18. Minase T, Ogasawara M, Kikuchi T, et al. Lymphomatoid granulomatosis: light microscopic, electron microscopic and immunohistochemical study . Acta Pathol Jpn. 1985;35:711-721. 19. Chan JKC, Ng CS, Lau WH, Lo STH. Most nasal/nasopharyngeal lymphomas are peripheral T-cell neoplasms . Am J Surg Pathol. 1987;11:418-429.Crossref 20. Petras RE, Tubbs RR, Gephardt GN, Sebek BA, Golish JA, Weick JK. T lymphocyte proliferation in lymphomatoid granulomatosis . Cleve Clin Q. 1985;52:137-146.Crossref 21. Whittaker S, Foroni L, Luzzatto L, et al. Lymphomatoid granulomatosis: evidence of a clonal T-cell origin and an association with lethal midline granuloma . Q J Med. 1988;68:645-655. 22. Donner LR, Dobin S, Harrington D, Bassion S, Rappaport ES, Peterson RF. Angiocentric immunoproliferative lesion (lymphomatoid granulomatosis): a cytogenetic, immunophenotypic, and genotypic study . Cancer . 1990;65:249-254.Crossref 23. Mittal K, Neri A, Feiner H, Schinella R, Alfonso F. Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome: evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement . Cancer . 1990;65:1345-1349.Crossref 24. Troussard X, Galateau F, Gaulard P, et al. Lymphomatoid granulomatosis in a patient with acute myeloblastic leukemia in remission . Cancer . 1990;65:107-111.Crossref 25. Katzenstein A-LA, Asken FB. Surgical Pathology of Non-Neoplastic Lung Disease . 2nd ed. Philadelphia, Pa: WB Saunders Co; 1990:306.

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1991

References