Abstract The study presents observations of biopsies from 47 patients with cutaneous sarcoidosis and 45 patients with tuberculoid leprosy. Epidermal changes showing parakeratosis, liquefaction degeneration, and glycogen occur more frequently in sarcoidosis. Nerve invasion is seen only in tuberculoid leprosy. Infiltration of arrectores pilorum muscles frequently occurs in tuberculoid leprosy and is rare in sarcoidosis. Fibrinoid degeneration within tubercles is common in sarcoidosis and absent in tuberculoid leprosy. Attachment of tubercles to the epidermis, sharp margination of the tubercles, and naked-appearing tubercles are seen more frequently in sarcoidosis than in tuberculoid leprosy. Elongateshaped tubercles and lymphocytes within, and forming a mantle about, tubercles are prominent and seen more frequently in tuberculoid leprosy. Cutaneous sarcoidosis and tuberculoid leprosy show similar microscopic features, but distinction can be made on the basis of critical histopathologic and histochemical evaluation. References 1. Binford, C.H.: Leprosy as a Diagnostic Problem in Surgical Pathology , Southern Med J 51:200-207 ( (Feb) ) 1958.Crossref 2. Binford, C.H., and Swan, L.L.: Tuberculoid Leprosy: Can a Pathologist Distinguish It From Other Granulomatous Diseases of the Skin? , read before the Meeting of The International Society of Clinical Pathology, Washington, DC, 1954. 3. James, D.G., and Jopling, W.H.: Sarcoidosis and Leprosy , J Trop Med 64:42-46 ( (Feb) ) 1961. 4. Ghosh, S.; Sen Gupta, P.C.; and Mukerjee, N.: Histochemical Study of Lepromatous Leprosy , Bull Calcutta Sch Trop Med 10:102-105 ( (July) ) 1962. 5. Mabalay, M.C., et al: The Histopathology and Histochemistry of Erythema Nodosum Leprosum , Int J Leprosy 33:28-49 (No. ( 1) ) 1965. 6. Kundu, S.; Ghosh, S.; and Sen Gupta, P.C.: Some Histochemical Observations on "Borderline" Leprosy , Bull Calcutta Sch Trop Med 12:63-66 ( (April) ) 1964. 7. Hollander, A., and Sommers, S.C.: Histochemical Comparison of Boeck's Sarcoid With Other Cutaneous Granulomas , Arch Derm 81:944-946 ( (June) ) 1960.Crossref 8. Hollander, A., and Sommers, S.C.: H Histochemical Study of Mucopolysaccharides of Leprosy of the Skin , Acta Dermatovener 3:407-411, 1957. 9. Movat, H.Z.: Demonstration of All Connective Tissue Elements in a Single Section: Pentachrome Stains , Arch Path 60:289-295 ( (Sept) ) 1955. 10. Johnson, W.C.; Graham, J.H.; and Helwig, E.B.: Histochemistry of the Acid Mucopolysaccharides in Cutaneous Calcification , J Invest Derm 42:215-224 ( (Feb) ) 1964. 11. Johnson, W.C.: " Histochemistry of Cutaneous Ground Substance ," in Bajusz, E.; and Jusmin, G. (eds): Methods and Achievements in Experimental Pathology , Basel, Switzerland: S. Karger, 1966, vol 1, pp 33-51. 12. Manual of Histologic and Special Staining Technics , ed 2, Armed Forces Institute of Pathology, New York: The Blakiston Division, McGrawHill Book Co., Inc., 1960. 13. Leprosy, Department of Medicine and Surgery , Veterans Administration, Medical Bulletin MB-10, Washington, DC, (May 25) , 1965. 14. Iyer, C.G.S.: Predilection of M leprae for Nerves: Neurohistopathologic Observations , Int J Leprosy 33:634-645 ( (May) ) 1965. 15. Netto, M.B.: Sarcoidose: Contribuicao ao Estudo de sua Patologia , Rio de Janeiro: Rodrigues and Cia, 1955, pp 1-114. 16. Ricker, W., and Clark, M.: Sarcoidosis: A Clinicopathologic Review of Three Hundred Cases, Including Twenty-Two Autopsies , Amer J Clin Path 19:725-749 ( (Aug) ) 1949. 17. Longcope, W.T., and Freiman, D.G.: A Study of Sarcoidosis , Baltimore: The Williams and Wilkins Company, 1952, pp 16-18. 18. Schujman, S.: Tuberculoid Lepra Reaction , Int J Leprosy 5:77-86 (No. ( 1) ) 1937.
Archives of Dermatology – American Medical Association
Published: Sep 1, 1967