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Cutaneous Manifestations of Tumoral Calcinosis

Cutaneous Manifestations of Tumoral Calcinosis Abstract We have followed up a large family in which seven members have tumoral calcinosis. One girl had the skin lesions of localized calcinosis cutis apart from the typical subcutaneous deposits of calcium. Like most persons with tumoral calcinosis, our patient had normal serum calcium concentrations; however, the serum phosphorus levels were greatly elevated. The familial occurrence and elevated serum phosphorus levels suggest the possibility of some as yet undefined, heritable metabolic defect as the underlying cause. The occurrence of tumoral calcinosis with localized calcinosis cutis is a rare association, and there has been only one other reported case to our knowledge. This report describes our patient and offers a brief discussion of tumoral calcinosis. The therapeutic response to the phosphate depletion regimen and topical steroids was disappointing in our case. (Arch Dermatol 115:1100-1102, 1979) References 1. Giard A: Sur la calcification hibernale . C R Soc Biol 10:1013-1015, 1898. 2. Duret MH: Tumeurs multiples et singulieres des bourses sereuses . Bull Soc Anat 74:725-731, 1899. 3. Inclan A: Tumoral calcinosis . JAMA 121:490-495, 1943.Crossref 4. Whiting DA, Simson IW, Kallmeyer JC, et al: Unusual cutaneous lesions in tumoral calcinosis . Arch Dermatol 102:465-473, 1970.Crossref 5. Longacre AM, Sheer AL: Tumoral calcinosis: Case presentations and review of 55 cases in the literature . J Fla Med Assoc 61:221-225, 1974. 6. Lafferty FW, Reynolds ES, Pearson OH: Tumoral calcinosis: A metabolic disease of obscure etiology . Am J Med 38:105-118, 1965.Crossref 7. Harkness JW, Peters HJ: Tumoral calcinosis: A report of six cases . J Bone Joint Surg Am 49:721-731, 1967. 8. Jegathesan S, Airan MC: Tumoral calcinosis: A disease of undetermined etiology . Am Surg 37:335-340, 1971. 9. Baldursson H, Evans EB, Dodge WF, et al: Tumoral calcinosis with hyperphosphatemia: A report of a family with incidence in four siblings . J Bone Joint Surg Am 51:913-925, 1969. 10. Wilber JF, Slatopolsky E: Hyperphosphatemia and tumoral calcinosis . Ann Intern Med 68:1044-1049, 1968.Crossref 11. Wilson AL, Chater E: Tumoral calcinosis: An obscure disease . J Ir Med Assoc 69:61-63, 1976. 12. McClatchie S, Bremner AD: Tumoral calcinosis: An unrecognized disease . Br Med J 1:153-155, 1969.Crossref 13. Palmer PES: Tumoral calcinosis . Br J Radiol 39:518-525, 1966.Crossref 14. Hug I, Guncaga J: Tumoral calcinosis with sedimentation sign . Br J Radiol 47:734-736, 1974.Crossref 15. Reddy CRR: Tumoral calcinosis . J Indian Med Assoc 43:336-337, 1964. 16. Mozaffarian G, Lafferty FW, Pearson OH: Treatment of tumoral calcinosis with phosphorus deprivation . Ann Intern Med 77:741-745, 1972.Crossref 17. Mozaffarian G, Nakhjavani MK, Hedayati MH, et al: Phosphorus deprivation treatment of tumoral calcinosis . Ann Intern Med 86:120, 1977.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010090050025
Publisher site
See Article on Publisher Site

Abstract

Abstract We have followed up a large family in which seven members have tumoral calcinosis. One girl had the skin lesions of localized calcinosis cutis apart from the typical subcutaneous deposits of calcium. Like most persons with tumoral calcinosis, our patient had normal serum calcium concentrations; however, the serum phosphorus levels were greatly elevated. The familial occurrence and elevated serum phosphorus levels suggest the possibility of some as yet undefined, heritable metabolic defect as the underlying cause. The occurrence of tumoral calcinosis with localized calcinosis cutis is a rare association, and there has been only one other reported case to our knowledge. This report describes our patient and offers a brief discussion of tumoral calcinosis. The therapeutic response to the phosphate depletion regimen and topical steroids was disappointing in our case. (Arch Dermatol 115:1100-1102, 1979) References 1. Giard A: Sur la calcification hibernale . C R Soc Biol 10:1013-1015, 1898. 2. Duret MH: Tumeurs multiples et singulieres des bourses sereuses . Bull Soc Anat 74:725-731, 1899. 3. Inclan A: Tumoral calcinosis . JAMA 121:490-495, 1943.Crossref 4. Whiting DA, Simson IW, Kallmeyer JC, et al: Unusual cutaneous lesions in tumoral calcinosis . Arch Dermatol 102:465-473, 1970.Crossref 5. Longacre AM, Sheer AL: Tumoral calcinosis: Case presentations and review of 55 cases in the literature . J Fla Med Assoc 61:221-225, 1974. 6. Lafferty FW, Reynolds ES, Pearson OH: Tumoral calcinosis: A metabolic disease of obscure etiology . Am J Med 38:105-118, 1965.Crossref 7. Harkness JW, Peters HJ: Tumoral calcinosis: A report of six cases . J Bone Joint Surg Am 49:721-731, 1967. 8. Jegathesan S, Airan MC: Tumoral calcinosis: A disease of undetermined etiology . Am Surg 37:335-340, 1971. 9. Baldursson H, Evans EB, Dodge WF, et al: Tumoral calcinosis with hyperphosphatemia: A report of a family with incidence in four siblings . J Bone Joint Surg Am 51:913-925, 1969. 10. Wilber JF, Slatopolsky E: Hyperphosphatemia and tumoral calcinosis . Ann Intern Med 68:1044-1049, 1968.Crossref 11. Wilson AL, Chater E: Tumoral calcinosis: An obscure disease . J Ir Med Assoc 69:61-63, 1976. 12. McClatchie S, Bremner AD: Tumoral calcinosis: An unrecognized disease . Br Med J 1:153-155, 1969.Crossref 13. Palmer PES: Tumoral calcinosis . Br J Radiol 39:518-525, 1966.Crossref 14. Hug I, Guncaga J: Tumoral calcinosis with sedimentation sign . Br J Radiol 47:734-736, 1974.Crossref 15. Reddy CRR: Tumoral calcinosis . J Indian Med Assoc 43:336-337, 1964. 16. Mozaffarian G, Lafferty FW, Pearson OH: Treatment of tumoral calcinosis with phosphorus deprivation . Ann Intern Med 77:741-745, 1972.Crossref 17. Mozaffarian G, Nakhjavani MK, Hedayati MH, et al: Phosphorus deprivation treatment of tumoral calcinosis . Ann Intern Med 86:120, 1977.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1979

References