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Cutaneous Formation of Vitamin D in Psoriasis

Cutaneous Formation of Vitamin D in Psoriasis Abstract To the Editor.— Vitamin D action requires epidermal synthesis (interaction of ultraviolet light B [UV-B] photons and 7-dehydrocholesterol molecules) and systemic activation in the liver and kidneys (to 25-dihydroxyvitamin D [25-OH-D] and 1,25-dihydroxyvitamin D [1,25-(OH)2-D]). A subtle or minimal impairment of this process was evaluated in the present study of patients with psoriasis of varying extent. The rationale for the investigation was (1) psoriasis is an epidermal disorder, and (2) psoriasis has been treated with the active vitamin D metabolite 1,25-(OH)2-D.1,2 Materials and Methods.— The study population was composed of 11 patients with psoriasis and 11 control subjects. Patients with psoriasis consisted of six men and five women with a mean age of 34 years (range, 25 to 69 years). Ten subjects were white and one was East Asian (Oriental). All had histologically confirmed psoriasis. At the time of the study, 10 of the patients References 1. Morimoto S, Onishi T, Imanaka S, et al. Topical administration of 1,25-dihydroxyvitamin D3 for psoriasis: report of five cases . Calcif Tissue Int. 1986;38:119-122.Crossref 2. Smith EL, Pincus SH, Donovan L, Holick MF. A novel approach for the evaluation and treatment of psoriasis . J Am Acad Dermatol. 1988;19:516-528.Crossref 3. Matsuoka LY, Wortsman J, Haddad JG, Hollis BW. In vivo threshold for cutaneous synthesis of vitamin D3 . J Lab Clin Med. 1989;114:301-305. 4. Smith EL, Walworth NC, Holick MF. Effect of 1,25-dihydroxyvitamin D, on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions . J Invest Dermatol. 1986;86:709-714.Crossref 5. MacLaughlin JA, Gange W, Taylor D, Smith E, Holick MF. Cultured psoriatic fibroblasts from involved and uninvolved sites have a partial but not absolute resistance to the proliferation-inhibition of 1,25-dihydroxyvitamin D3 . Proc Natl Acad Sci U S A. 1985;82:5409-5412.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous Formation of Vitamin D in Psoriasis

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Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1990.01670320131033
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Vitamin D action requires epidermal synthesis (interaction of ultraviolet light B [UV-B] photons and 7-dehydrocholesterol molecules) and systemic activation in the liver and kidneys (to 25-dihydroxyvitamin D [25-OH-D] and 1,25-dihydroxyvitamin D [1,25-(OH)2-D]). A subtle or minimal impairment of this process was evaluated in the present study of patients with psoriasis of varying extent. The rationale for the investigation was (1) psoriasis is an epidermal disorder, and (2) psoriasis has been treated with the active vitamin D metabolite 1,25-(OH)2-D.1,2 Materials and Methods.— The study population was composed of 11 patients with psoriasis and 11 control subjects. Patients with psoriasis consisted of six men and five women with a mean age of 34 years (range, 25 to 69 years). Ten subjects were white and one was East Asian (Oriental). All had histologically confirmed psoriasis. At the time of the study, 10 of the patients References 1. Morimoto S, Onishi T, Imanaka S, et al. Topical administration of 1,25-dihydroxyvitamin D3 for psoriasis: report of five cases . Calcif Tissue Int. 1986;38:119-122.Crossref 2. Smith EL, Pincus SH, Donovan L, Holick MF. A novel approach for the evaluation and treatment of psoriasis . J Am Acad Dermatol. 1988;19:516-528.Crossref 3. Matsuoka LY, Wortsman J, Haddad JG, Hollis BW. In vivo threshold for cutaneous synthesis of vitamin D3 . J Lab Clin Med. 1989;114:301-305. 4. Smith EL, Walworth NC, Holick MF. Effect of 1,25-dihydroxyvitamin D, on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions . J Invest Dermatol. 1986;86:709-714.Crossref 5. MacLaughlin JA, Gange W, Taylor D, Smith E, Holick MF. Cultured psoriatic fibroblasts from involved and uninvolved sites have a partial but not absolute resistance to the proliferation-inhibition of 1,25-dihydroxyvitamin D3 . Proc Natl Acad Sci U S A. 1985;82:5409-5412.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1990

References