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Cutaneous Chronic Graft-vs-Host Disease and Hepatitis C Virus

Cutaneous Chronic Graft-vs-Host Disease and Hepatitis C Virus Abstract Chronic graft-vs-host disease (GVHD) is a significant problem in patients who undergo bone marrow transplantation (BMT). It shares common clinical and histologic characteristics with lichen planus. The association of hepatitis C virus (HCV)-induced chronic hepatitis and lichen planus has been reported recently.1 To evaluate the possible role of HCV in the pathogenesis of chronic GVHD, two studies were performed in the BMT unit of our institution. Patients and Methods.Cohort Study. One hundred twenty-six consecutive patients who underwent allogeneic BMT between January 1987 and December 1991, with more than 6 months of follow-up post-BMT, were analyzed retrospectively. The mean age was 31 years. Chronic GVHD was defined as previously.2 Serum samples were obtained before and after BMT (mean delay, 11 months; [range, 6 to 54 months]). Anti-HCV antibodies were sought by a second-generation enzyme-linked immunosorbent assay (ELISA 2.0, Ortho Diagnostic Systems, Raritan, NJ) and a second-generation recombinant immunoblot References 1. Jubert C, Pawlotsky JM, Pouget F, et al. Lichen planus and hepatitis C virus-related chronic active hepatitis . Arch Dermatol. 1994;130:73-76.Crossref 2. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-vs-host syndrome in man: a long-term clinicopathological study of 20 Seattle patients . Am J Med. 1980;69:204-217.Crossref 3. Pawlotsky JM, Fleury A, Choukroun V, et al. Significance of highly positive c22-3 'indeterminate' second-generation hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) and resolution by third-generation HCV RIBA . J Clin Microbiol. 1994;32:1357-1359. 4. Boström L, Ringden O, Sundberg B, Ljungman P, Linde A, Nilsson B. Pretransplant herpes virus serology and chronic graft-vs-host disease . Bone Marrow Transplant . 1989;4:547-552. 5. Pawlotsky JM, Ben Yahia M, André C, et al. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study . Hepatology . 1994;19:841-848.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690190109030
Publisher site
See Article on Publisher Site

Abstract

Abstract Chronic graft-vs-host disease (GVHD) is a significant problem in patients who undergo bone marrow transplantation (BMT). It shares common clinical and histologic characteristics with lichen planus. The association of hepatitis C virus (HCV)-induced chronic hepatitis and lichen planus has been reported recently.1 To evaluate the possible role of HCV in the pathogenesis of chronic GVHD, two studies were performed in the BMT unit of our institution. Patients and Methods.Cohort Study. One hundred twenty-six consecutive patients who underwent allogeneic BMT between January 1987 and December 1991, with more than 6 months of follow-up post-BMT, were analyzed retrospectively. The mean age was 31 years. Chronic GVHD was defined as previously.2 Serum samples were obtained before and after BMT (mean delay, 11 months; [range, 6 to 54 months]). Anti-HCV antibodies were sought by a second-generation enzyme-linked immunosorbent assay (ELISA 2.0, Ortho Diagnostic Systems, Raritan, NJ) and a second-generation recombinant immunoblot References 1. Jubert C, Pawlotsky JM, Pouget F, et al. Lichen planus and hepatitis C virus-related chronic active hepatitis . Arch Dermatol. 1994;130:73-76.Crossref 2. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-vs-host syndrome in man: a long-term clinicopathological study of 20 Seattle patients . Am J Med. 1980;69:204-217.Crossref 3. Pawlotsky JM, Fleury A, Choukroun V, et al. Significance of highly positive c22-3 'indeterminate' second-generation hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) and resolution by third-generation HCV RIBA . J Clin Microbiol. 1994;32:1357-1359. 4. Boström L, Ringden O, Sundberg B, Ljungman P, Linde A, Nilsson B. Pretransplant herpes virus serology and chronic graft-vs-host disease . Bone Marrow Transplant . 1989;4:547-552. 5. Pawlotsky JM, Ben Yahia M, André C, et al. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study . Hepatology . 1994;19:841-848.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1995

References