Abstract
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AMERICAN ATABRINE The most prevalent disease afflicting the populations of the world is undoubtedly malaria. How many cases occur each year is not known, but estimates place the number as high as 800,000,000. In local areas, particularly in the United States and Panama, drainage and sanitary engineering projects have had some influence on the incidence of malaria, but such measures cannot cope with the disease on a worldwide basis. Until 1932 the populations of the world were principally dependent on quinine and its derivatives for protection against the malady. With the discovery of Atabrine in 1932 a new and potent addition to the antimalarial armamentarium made its appearance. When the Netherland East Indies fell to Japan, the source of practically the entire world supply of quinine was lost to the United Nations. Atabrine, now officially recognized under the nonproprietary name quinacrine, assumed a role of unsurpassed importance as a strategic
JAMA – American Medical Association
Published: Nov 14, 1942
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