Abstract To the Editor.— A 40-year-old man was suffering from recurrent stomatitis for 26 years. He was treated by his family doctor with oral disinfectants, liver extract, vitamin B complex, and antibiotics, without any success. His family doctor told him that the disease was incurable. The cause of the stomatitis was not known. Often, he could not enjoy his food, and he sometimes had difficulty in speaking. When one side of the mouth or tongue began to heal, then blisters began to appear on the other side of the mouth. The condition persisted.It is known that enteroviruses, herpes simplex, and vaccinia virus which are pretreated with neutral red are inactivated photodynamically.1 The patient was advised to use 0.8% neutral red solution with subsequent exposure to white light. Every evening, he applied the neutral red solution to his mouth with a swab (dye was easily taken up by References 1. Wallis C, Scheiris C, Melnic JL: Photodynamically inactivated vaccines prepared by growing viruses in cells containing neutral red . J Immun 99:1134-1139, 1967.
Archives of Dermatology – American Medical Association
Published: Sep 1, 1972