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Cure of Cryptococcemia and Preservation of Graft Function in a Renal Transplant Recipient

Cure of Cryptococcemia and Preservation of Graft Function in a Renal Transplant Recipient Abstract • Disseminated cryptococcosis with cryptococcemia occurred in a renal transplant patient in whom immunosuppression was continued throughout antifungal therapy in an effort to ensure graft viability. Despite the initial presence of positive fungal cultures of blood, urine, and CSF, infection cleared rapidly, and there has been no evidence of recurrence. Throughout this period, renal function remained unaltered. This favorable outcome suggests that the prognosis for the renal transplant recipient with disseminated cryptococcosis may be improved. (Arch Intern Med 1984;144-1877-1878) References 1. Hooper DC, Pruitt AA, Rubin RH: Central nervous system infection in the chronically immunosuppressed. Medicine 1982;61:160-188.Crossref 2. Diamond RD, Bennett JE: Prognostic factors in cryptococcal meningitis. Ann Intern Med 1974;80:176-181.Crossref 3. Perfect JR, Durack DT, Gallis HA: Cryptococcemia. Medicine 1983; 62:98-109.Crossref 4. Eiser AR, Neff MS, Slifkin RF: Cure of cryptococcemia in an immunosuppressed patient with lupus nephritis. Am J Nephrol 1982;2:95-97.Crossref 5. Gallis HA, Berman RA, Cate TR, et al: Fungal infection following renal transplantation. Arch Intern Med 1975;135:1163-1172.Crossref 6. Schroter GPJ, Temple DR, Husberg BS, et al: Cryptococcosis after renal transplantation: Report of the cases. Surgery 1976;3:268-277. 7. Fraser DW, Ward JI, Ajello L: Aspergillosis and systemic mycosis. JAMA 1979;242:1631-1635.Crossref 8. Perfect JR, Levy SDR, Durack DT: Chronic cryptococcal meningitis: A new experimental model in rabbits. Am J Pathol 1980;101:177-193. 9. Gadesbusch MH, Gilers PW: The effect of cortisone upon experimental pulmonary cryptococcosis. Am Rev Respir Dis 1965;92:64. 10. Diamond RD, Bennett JE: Disseminated cryptococcosis in man: Decreased lymphocyte transformation in response to Cryptococcus neoformans. J Infect Dis 1973;127:694-697.Crossref 11. Abdou NI, Zweiman B, Casella SR: Effects of azathioprine therapy on bone marrow dependent and thymus dependent cells in man. Clin Exp Immunol 1973;13:55-64. 12. Meunier-Carpentier F, Kiehn TE, Armstrong D: Fungemia in the immunocompromised host. Am J Med 1981;71:363-370.Crossref 13. Butler WT, Bennett JE, Ailing DW, et al: Diagnostic and prognostic value of clinical and laboratory findings in cryptococcal meningitis. N Engl J Med 1964;270:59-67.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Cure of Cryptococcemia and Preservation of Graft Function in a Renal Transplant Recipient

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350210207039
Publisher site
See Article on Publisher Site

Abstract

Abstract • Disseminated cryptococcosis with cryptococcemia occurred in a renal transplant patient in whom immunosuppression was continued throughout antifungal therapy in an effort to ensure graft viability. Despite the initial presence of positive fungal cultures of blood, urine, and CSF, infection cleared rapidly, and there has been no evidence of recurrence. Throughout this period, renal function remained unaltered. This favorable outcome suggests that the prognosis for the renal transplant recipient with disseminated cryptococcosis may be improved. (Arch Intern Med 1984;144-1877-1878) References 1. Hooper DC, Pruitt AA, Rubin RH: Central nervous system infection in the chronically immunosuppressed. Medicine 1982;61:160-188.Crossref 2. Diamond RD, Bennett JE: Prognostic factors in cryptococcal meningitis. Ann Intern Med 1974;80:176-181.Crossref 3. Perfect JR, Durack DT, Gallis HA: Cryptococcemia. Medicine 1983; 62:98-109.Crossref 4. Eiser AR, Neff MS, Slifkin RF: Cure of cryptococcemia in an immunosuppressed patient with lupus nephritis. Am J Nephrol 1982;2:95-97.Crossref 5. Gallis HA, Berman RA, Cate TR, et al: Fungal infection following renal transplantation. Arch Intern Med 1975;135:1163-1172.Crossref 6. Schroter GPJ, Temple DR, Husberg BS, et al: Cryptococcosis after renal transplantation: Report of the cases. Surgery 1976;3:268-277. 7. Fraser DW, Ward JI, Ajello L: Aspergillosis and systemic mycosis. JAMA 1979;242:1631-1635.Crossref 8. Perfect JR, Levy SDR, Durack DT: Chronic cryptococcal meningitis: A new experimental model in rabbits. Am J Pathol 1980;101:177-193. 9. Gadesbusch MH, Gilers PW: The effect of cortisone upon experimental pulmonary cryptococcosis. Am Rev Respir Dis 1965;92:64. 10. Diamond RD, Bennett JE: Disseminated cryptococcosis in man: Decreased lymphocyte transformation in response to Cryptococcus neoformans. J Infect Dis 1973;127:694-697.Crossref 11. Abdou NI, Zweiman B, Casella SR: Effects of azathioprine therapy on bone marrow dependent and thymus dependent cells in man. Clin Exp Immunol 1973;13:55-64. 12. Meunier-Carpentier F, Kiehn TE, Armstrong D: Fungemia in the immunocompromised host. Am J Med 1981;71:363-370.Crossref 13. Butler WT, Bennett JE, Ailing DW, et al: Diagnostic and prognostic value of clinical and laboratory findings in cryptococcal meningitis. N Engl J Med 1964;270:59-67.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1984

References