Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

CURATIVE EFFECT OF BISMUTH COMPOUNDS IN EXPERIMENTAL RABBIT SYPHILIS

CURATIVE EFFECT OF BISMUTH COMPOUNDS IN EXPERIMENTAL RABBIT SYPHILIS Abstract Since 1919, when Sazerac and Levaditi1 published their researches on the antisyphilitic effect of bismuth compounds, there have been many contributions on the spirocheticidal value of this product. The strange thing is that while bismuth is known to possess considerable curative power both in experimental rabbit syphilis and human syphilis, and a feeble effect in trypanosome infections, it was on the basis of its trypanocidal properties that the drug was first introduced into medicine. The discoverers of these trypanocidal effects were Robert and Sauton.2 Our own study of the value of bismuth compounds in trypanosomiasis caused by Trypanosoma equiperdum shows that bismuth possesses practically no curative power. A study of Table 1 demonstrates that potassium bismuth tartrate in as high a dose as 0.015 per kilogram failed to diminish the number of trypanosomes in the blood, the animal having died from infection on the sixth day. Arsphenamin, in References 1. Sazerac and Levaditi: Compt. rend. Soc. de biol. 172:1391, 1921. 2. Robert and Sauton: Ann. de l'Inst. Pasteur 30:261, 1916. 3. Plaut and Mulzer: München. med. Wchnschr. 16:487, 1923. 4. Klauder, J.: Comparative Spirocheticidal Activity of Salts of Metals not Heretofore Studied in Treatment of Experimental Rabbit Syphilis , Arch. Dermat. & Syph. 9:219 ( (Feb.) ) 1924 5. Klauder, J.: Bismuth in Treatment of Syphilis , Arch. Dermat. & Syph. 7:721 ( (June) ) 1923. 6. Hopkins, J.: Bismuth in Treatment of Syphilis , Arch. Dermat. & Syph. 7:745 ( (June) ) 1923. 7. The author stated that in some animals active syphilitic lesions recur after this period. 8. Kuznitsky, E.: Beiträge zur Pathologie u. Therapie der Syphilis, Berlin , 1911, p. 295. 9. Neisser, A.: Beiträge zur Pathologie u. Therapie der Syphilis, p. 182. 10. Kolle, W.: Deutsch. med. Wchnschr. 48:1301, 1922. 11. Pearce and Brown: J. Exper. Med. 35:39, 1922. 12. Chesney, A:. J. Exper. Med. 39:553, 1924. 13. Raiziss, G. W., and Brown, H.: Toxicity and Reactions Caused by Arsphenamin; Effect of Organic Compounds of Arsenic, Mercury and Bismuth on Kidneys of Animals, Judged by Nonprotein Nitrogen and Urea Content of Blood , Arch. Dermat. & Syph. 10:1 ( (July) ) 1924. 14. The maximum tolerated dose for arsphenamin was determined on rabbits, which tolerate less than rats. Arsphenamin is tested as a routine on rats and higher figures for the maximum tolerated dose are usually obtained. However, we wanted to secure the data for the chemotherapeutic index on the rabbit. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

CURATIVE EFFECT OF BISMUTH COMPOUNDS IN EXPERIMENTAL RABBIT SYPHILIS

Download PDF
9 pages

Loading next page...
 
/lp/american-medical-association/curative-effect-of-bismuth-compounds-in-experimental-rabbit-syphilis-vHRYZRVcby

References (3)

Publisher
American Medical Association
Copyright
Copyright © 1925 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1925.02370110050006
Publisher site
See Article on Publisher Site

Abstract

Abstract Since 1919, when Sazerac and Levaditi1 published their researches on the antisyphilitic effect of bismuth compounds, there have been many contributions on the spirocheticidal value of this product. The strange thing is that while bismuth is known to possess considerable curative power both in experimental rabbit syphilis and human syphilis, and a feeble effect in trypanosome infections, it was on the basis of its trypanocidal properties that the drug was first introduced into medicine. The discoverers of these trypanocidal effects were Robert and Sauton.2 Our own study of the value of bismuth compounds in trypanosomiasis caused by Trypanosoma equiperdum shows that bismuth possesses practically no curative power. A study of Table 1 demonstrates that potassium bismuth tartrate in as high a dose as 0.015 per kilogram failed to diminish the number of trypanosomes in the blood, the animal having died from infection on the sixth day. Arsphenamin, in References 1. Sazerac and Levaditi: Compt. rend. Soc. de biol. 172:1391, 1921. 2. Robert and Sauton: Ann. de l'Inst. Pasteur 30:261, 1916. 3. Plaut and Mulzer: München. med. Wchnschr. 16:487, 1923. 4. Klauder, J.: Comparative Spirocheticidal Activity of Salts of Metals not Heretofore Studied in Treatment of Experimental Rabbit Syphilis , Arch. Dermat. & Syph. 9:219 ( (Feb.) ) 1924 5. Klauder, J.: Bismuth in Treatment of Syphilis , Arch. Dermat. & Syph. 7:721 ( (June) ) 1923. 6. Hopkins, J.: Bismuth in Treatment of Syphilis , Arch. Dermat. & Syph. 7:745 ( (June) ) 1923. 7. The author stated that in some animals active syphilitic lesions recur after this period. 8. Kuznitsky, E.: Beiträge zur Pathologie u. Therapie der Syphilis, Berlin , 1911, p. 295. 9. Neisser, A.: Beiträge zur Pathologie u. Therapie der Syphilis, p. 182. 10. Kolle, W.: Deutsch. med. Wchnschr. 48:1301, 1922. 11. Pearce and Brown: J. Exper. Med. 35:39, 1922. 12. Chesney, A:. J. Exper. Med. 39:553, 1924. 13. Raiziss, G. W., and Brown, H.: Toxicity and Reactions Caused by Arsphenamin; Effect of Organic Compounds of Arsenic, Mercury and Bismuth on Kidneys of Animals, Judged by Nonprotein Nitrogen and Urea Content of Blood , Arch. Dermat. & Syph. 10:1 ( (July) ) 1924. 14. The maximum tolerated dose for arsphenamin was determined on rabbits, which tolerate less than rats. Arsphenamin is tested as a routine on rats and higher figures for the maximum tolerated dose are usually obtained. However, we wanted to secure the data for the chemotherapeutic index on the rabbit.

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Nov 1, 1925

There are no references for this article.