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CURARE AND METRAZOL THERAPY OF PSYCHOSES: REPORT OF A FATAL CASE

CURARE AND METRAZOL THERAPY OF PSYCHOSES: REPORT OF A FATAL CASE Abstract For several years metrazol has been widely used intravenously to produce convulsions in the shock therapy of various psychoses. One of the most important disadvantages of this form of therapy has been the production of injuries by the severe convulsions. These injuries have included fractures of the dorsal vertebrae, femur, pelvis and humerus, as well as dislocations of the shoulder and mandible.1 Various workers have employed a variety of methods to reduce the severity of metrazol-induced convulsions and consequent injuries. These methods, including the use of restraints, postures, supports, splints and spinal anesthesia, have had some success, but all have important disadvantages. Bennett2 first described the use of curare in modifying the metrazol convulsion, and numerous other workers have employed this drug, with excellent results, in preventing injuries due to convulsions. Curare has been used since the time of Claude Bernard as a laboratory drug for blocking nerve References 1. Hamsa, W. R., and Bennett, A. E.: Traumatic Complications of Convulsive Shock Therapy , J. A. M. A. 112:2244 ( (June 3) ) 1939.Crossref 2. Polatin, P.; Friedman, M. M., and Horwitz, W. A.: Vertebral Fractures Produced by Metrazol Induced Convulsions , J. A. M. A. 112:1684 ( (April 29) ) 1939.Crossref 3. Bennett, B. F., Jr., and Fitzpatrick, C. P.: Fractures of the Spine Complicating Metrazol Therapy , J. A. M. A. 112:2240 ( (June 3) ) 1939.Crossref 4. Graves, C. C., and Pignataro, T. P.: Injuries Sustained During the Course of Metrazol Shock Therapy , Psychiatric Quart. 14:477 ( (July) ) 1940.Crossref 5. Bennett, A. E.: Preventing Traumatic Complications in Convulsive Shock Therapy by Curare , J. A. M. A. 114:322 ( (Jan. 27) ) 1940.Crossref 6. West, R.: Intravenous Curare in Treatment of Tetanus , Lancet 1:12-16 ( (Jan. 4) ) 1936.Crossref 7. Burman, M. S.: Therapeutic Use of Curare and Erythroidine Hydrochloride for Spastic and Dystonic States , Arch. Neurol. & Psychiat. 41:307-327 ( (Feb.) ) 1939. 8. Bennett.2 9. McIntyre, A. R.: Personal communication to the authors, April 5, 1941. 10. Intocostrin, manufactured by E. R. Squibb & Sons, New York. 11. Hayman, M., and Brody, M. W.: Metrazol Therapy in Schizophrenia: Fatal Case with Autopsy , J. A. M. A. 112:310-311 ( (Jan. 28) ) 1939. 12. Pessin, J., and Reese, H. H.: Fatal Complication Following Metrazol Treatment for Schizophrenia , Am. J. Psychiat. 96:393-395 ( (Sept.) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

CURARE AND METRAZOL THERAPY OF PSYCHOSES: REPORT OF A FATAL CASE

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290080113005
Publisher site
See Article on Publisher Site

Abstract

Abstract For several years metrazol has been widely used intravenously to produce convulsions in the shock therapy of various psychoses. One of the most important disadvantages of this form of therapy has been the production of injuries by the severe convulsions. These injuries have included fractures of the dorsal vertebrae, femur, pelvis and humerus, as well as dislocations of the shoulder and mandible.1 Various workers have employed a variety of methods to reduce the severity of metrazol-induced convulsions and consequent injuries. These methods, including the use of restraints, postures, supports, splints and spinal anesthesia, have had some success, but all have important disadvantages. Bennett2 first described the use of curare in modifying the metrazol convulsion, and numerous other workers have employed this drug, with excellent results, in preventing injuries due to convulsions. Curare has been used since the time of Claude Bernard as a laboratory drug for blocking nerve References 1. Hamsa, W. R., and Bennett, A. E.: Traumatic Complications of Convulsive Shock Therapy , J. A. M. A. 112:2244 ( (June 3) ) 1939.Crossref 2. Polatin, P.; Friedman, M. M., and Horwitz, W. A.: Vertebral Fractures Produced by Metrazol Induced Convulsions , J. A. M. A. 112:1684 ( (April 29) ) 1939.Crossref 3. Bennett, B. F., Jr., and Fitzpatrick, C. P.: Fractures of the Spine Complicating Metrazol Therapy , J. A. M. A. 112:2240 ( (June 3) ) 1939.Crossref 4. Graves, C. C., and Pignataro, T. P.: Injuries Sustained During the Course of Metrazol Shock Therapy , Psychiatric Quart. 14:477 ( (July) ) 1940.Crossref 5. Bennett, A. E.: Preventing Traumatic Complications in Convulsive Shock Therapy by Curare , J. A. M. A. 114:322 ( (Jan. 27) ) 1940.Crossref 6. West, R.: Intravenous Curare in Treatment of Tetanus , Lancet 1:12-16 ( (Jan. 4) ) 1936.Crossref 7. Burman, M. S.: Therapeutic Use of Curare and Erythroidine Hydrochloride for Spastic and Dystonic States , Arch. Neurol. & Psychiat. 41:307-327 ( (Feb.) ) 1939. 8. Bennett.2 9. McIntyre, A. R.: Personal communication to the authors, April 5, 1941. 10. Intocostrin, manufactured by E. R. Squibb & Sons, New York. 11. Hayman, M., and Brody, M. W.: Metrazol Therapy in Schizophrenia: Fatal Case with Autopsy , J. A. M. A. 112:310-311 ( (Jan. 28) ) 1939. 12. Pessin, J., and Reese, H. H.: Fatal Complication Following Metrazol Treatment for Schizophrenia , Am. J. Psychiat. 96:393-395 ( (Sept.) ) 1939.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Aug 1, 1942

References