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Crow's 'Lateralization Hypothesis' for Schizophrenia

Crow's 'Lateralization Hypothesis' for Schizophrenia Abstract To the Editor.— Crow and colleagues1 have presented another ingenious and provocative theory about schizophernia that should lead to a new round of thinking and research about the relationship of cerebral lateralization to this disorder. Their assertion that schizophrenia involves an abnormality of the development of normal cerebral anatomic asymmetries is based, to a considerable degree, on their own findings of parahippocampal gyrus width2 and asymmetries of ventricular size1 in patients with schizophrenia. While we agree that when abnormalities of only one hemisphere have been reported in studies of patients with schizophrenia, the left side is more often implicated, we do not feel that the data are sufficiently robust to conclude that the pathologic process itself is lateralized or that the process "disturbs the mechanisms of lateralization."1The lateralization theory of Crow et al owes much to an earlier finding of reduced parahippocampal gyral width in References 1. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, Frith CD, Johnstone EC, Owens DGC, Roberts GW. Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease . Arch Gen Psychiatry . 1989;46:1145-1150.Crossref 2. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L. Postmortem evidence of structural brain changes in schizophrenia: differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder . Arch Gen Psychiatry . 1986;43:36-42.Crossref 3. Altshuler LL, Casanova MF, Goldberg T, Post R, Kleinman JE. Shape and area of the hippocampus and parahippocampal gyrus in schizophrenic, suicide and control brains . Arch Gen Psychiatry . In press. 4. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Cerebral anatomical abnormalities in monozygotic twins discordant for schizophrenia . N Engl J Med . 1990;322:789-794.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Crow's 'Lateralization Hypothesis' for Schizophrenia

Abstract

Abstract To the Editor.— Crow and colleagues1 have presented another ingenious and provocative theory about schizophernia that should lead to a new round of thinking and research about the relationship of cerebral lateralization to this disorder. Their assertion that schizophrenia involves an abnormality of the development of normal cerebral anatomic asymmetries is based, to a considerable degree, on their own findings of parahippocampal gyrus width2 and asymmetries of ventricular size1...
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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1991.01810250087013
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Crow and colleagues1 have presented another ingenious and provocative theory about schizophernia that should lead to a new round of thinking and research about the relationship of cerebral lateralization to this disorder. Their assertion that schizophrenia involves an abnormality of the development of normal cerebral anatomic asymmetries is based, to a considerable degree, on their own findings of parahippocampal gyrus width2 and asymmetries of ventricular size1 in patients with schizophrenia. While we agree that when abnormalities of only one hemisphere have been reported in studies of patients with schizophrenia, the left side is more often implicated, we do not feel that the data are sufficiently robust to conclude that the pathologic process itself is lateralized or that the process "disturbs the mechanisms of lateralization."1The lateralization theory of Crow et al owes much to an earlier finding of reduced parahippocampal gyral width in References 1. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, Frith CD, Johnstone EC, Owens DGC, Roberts GW. Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease . Arch Gen Psychiatry . 1989;46:1145-1150.Crossref 2. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L. Postmortem evidence of structural brain changes in schizophrenia: differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder . Arch Gen Psychiatry . 1986;43:36-42.Crossref 3. Altshuler LL, Casanova MF, Goldberg T, Post R, Kleinman JE. Shape and area of the hippocampus and parahippocampal gyrus in schizophrenic, suicide and control brains . Arch Gen Psychiatry . In press. 4. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Cerebral anatomical abnormalities in monozygotic twins discordant for schizophrenia . N Engl J Med . 1990;322:789-794.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jan 1, 1991

References