Abstract THE PROCEDURE for extracorporeal circulation to be described is a relatively simple operation in which one animal (donor) provides the functions of the heart and lungs for himself and for a second animal (recipient) as well. By means of cross circulation an adequate supply of oxygenated blood is delivered to the recipient in order that the heart may be bypassed either in whole or in part, thus making experimental intracardiac surgery possible in laboratories where a mechanical heart or heart-lung is not at hand. It is the purpose of this paper to present the details of a workable cross circulation together with the results in an initial 20 pairs of dogs in which the left heart was bypassed. METHOD Healthy mongrel dogs at least 15 kg. in weight are chosen, a larger dog serving as donor for a smaller one when possible. Sodium pentobarbital is used for anesthesia; the donor References 1. Parkin, T. W., and Kvale, W. F.: Neutralization of the Anticoagulant Effects of Heparin with Protamine (Salmine) , Am. Heart J. 37:333, 1949.Crossref 2. Hunter, F. T.; Grove-Rasmussen, M., and Soutter, L.: A Spectrophotometric Method for Quantitating Hemoglobin in Plasma or Serum , Am. J. Clin. Path. 20:429, 1950. 3. Leeds, S. E.: Proc. Soc. Exper. Biol. & Med. 75:468, 1950 4. Jacobj, C.: Apparat zur Durchblutung isolirter überlebender Organe , Arch. exper. Path. u. Pharmakol. 26:388, 1890. 5. Bazett, H. C., and Quinby, W. C.: A New Method for Crossed Circulation Experiments, with Some Observations on the Nature of Pressor Reflexes , Quart. J. Exper. Physiol. 12:199, 1919-20. 6. Firor, W. M.: Experiments in Cross Circulation , Am. J. Physiol. 96:146, 1931. 7. Gibbon, J. H., Jr.: The Maintenance of Life During Experimental Occlusion of Pulmonary Artery , Arch. Sug. 34:1105, 1937. 8. Gibbon, J. H., Jr., and Kraul, C. W.: An Efficient Oxygenator for Blood , J. Lab. & Clin. Med. 26:1803, 1941. 9. Gibbon, J. H., Jr.: Artificial Maintenance of the Circulation, Symposium, Surgery Study Section, Federal Security Agency, United States Public Health Service, Jan. 21, 1950. 10. Crafoord, C.: Some Aspects of the Development of Intrathoracic Surgery , Surg., Gynec. & Obst. 89:629, 1949. 11. Jongbloed, J.: The Mechanical Heart-Lung System , Surg., Gynec. & Obst. 89:684, 1949. 12. Karlson, K. E.; Dennis, C.; Westover, D., and Sanderson, D.: Pump-Oxygenator to Supplant the Heart and Lungs for Brief Periods: I. Evaluation of Oxygenator Techniques; An Efficient Oxygenator , Surgery 29:678, 1951. 13. Dennis, C.; Karlson, K. E.; Eder, W. P.; Nelson, R. M.; Eddy, F. D., and Sanderson, D.: Pump-Oxygenator to Supplant the Heart and Lungs for Brief Periods: II. A Method Applicable to Dogs , Surgery 29:697, 1951. 14. Wesolowski, S.; Miller, H. H.; Halkett, J. A. E., and Welch, C. S.: Experimental Replacement of the Heart by a Mechanical Extracorporeal Pump , Bull. New England M. Center 12:41, 1950. 15. Kantrowitz, Adrian, and Kantrowitz, Arthur: Experimental Artificial Left Heart to Permit Surgical Exposure of Mitral Valve in Cats , Proc. Soc. Exper. Biol. & Med. 74:193, 1950.
A.M.A. Archives Surgery – American Medical Association
Published: Jan 1, 1952
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