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CROSS-ALLERGENICITY OF PENICILLINS AND CEPHALOSPORINS

CROSS-ALLERGENICITY OF PENICILLINS AND CEPHALOSPORINS Iatrogenic disease due to the chemical effects of antimicrobial agents may be divided into hypersensitivity and toxic reactions. Penicillin is commonly regarded today as the medicament most likely to cause allergic effects in man, including urticarial, serum-sickness-like, and anaphylactic reactions. It is estimated that 5% to 6% of the population has been sensitized to this antibiotic. All penicillin derivatives, including penicillin 0, are immunologically cross-reactive, as borne out by clinical experience and studies of skin-tests hemagglutination inhibition, and basophil degranulation. Hope for similar antibiotic action without crosssensitivity came with the development of the cephalosporins. These compounds, derived from a species of Cephalosporium rather than a Penicillium, are substitution products of 7-aminocephalosporanic acid. In addition to the varying side chain structures, the cephalosporins differ from the penicillins in that a six-membered dihydrothiazine ring replaces the five-membered thiazolidine ring. Reports of failure to observe cross-reactions after intradermal tests with cephalosporin C in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

CROSS-ALLERGENICITY OF PENICILLINS AND CEPHALOSPORINS

JAMA , Volume 199 (7) – Feb 13, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1967.03120070107021
Publisher site
See Article on Publisher Site

Abstract

Iatrogenic disease due to the chemical effects of antimicrobial agents may be divided into hypersensitivity and toxic reactions. Penicillin is commonly regarded today as the medicament most likely to cause allergic effects in man, including urticarial, serum-sickness-like, and anaphylactic reactions. It is estimated that 5% to 6% of the population has been sensitized to this antibiotic. All penicillin derivatives, including penicillin 0, are immunologically cross-reactive, as borne out by clinical experience and studies of skin-tests hemagglutination inhibition, and basophil degranulation. Hope for similar antibiotic action without crosssensitivity came with the development of the cephalosporins. These compounds, derived from a species of Cephalosporium rather than a Penicillium, are substitution products of 7-aminocephalosporanic acid. In addition to the varying side chain structures, the cephalosporins differ from the penicillins in that a six-membered dihydrothiazine ring replaces the five-membered thiazolidine ring. Reports of failure to observe cross-reactions after intradermal tests with cephalosporin C in

Journal

JAMAAmerican Medical Association

Published: Feb 13, 1967

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