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Cromolyn Therapy in Chronic Infantile Eczema

Cromolyn Therapy in Chronic Infantile Eczema Abstract To the Editor.— The principal effect of cromolyn sodium (disodium cromoglycate) is believed to be inhibition of the release of chemical mediators on anaphylaxis from sensitized mast cells.1 There are some indications2,3 that cromolyn taken orally may inhibit the development of gastrointestinal manifestations of food allergy. Also, cromolyn may block the development of remote manifestations, such as urticaria, following ingestion of an offending food allergen.This report documents what is believed to be the first recorded use of cromolyn in the treatment of infantile eczema. Report of a Case.— The patient is a 6-year-old boy, whose eczema was first diagnosed at eight weeks of age. His disease was of sufficient intensity to require hospitalization on five occasions during the first 24 months of life. Intermittent therapy with oral steroids as well as nearly continuous application of topical steroids have been necessary to control his skin lesions.At five References 1. Cox JSG: Disodium cromoglycate (FPL 670) (`Intal'): A specific inhibitor of reaginic antibody-antigen mechanisms . Nature 216:1328-1329, 1967.Crossref 2. Freier S, Berger H: Disodium cromoglycate in gastrointestinal protein intolerance . Lancet 1:913-915, 1973.Crossref 3. Freier S: Pediatric gastrointestinal allergy . Clin Allergy 3:597-618, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cromolyn Therapy in Chronic Infantile Eczema

Archives of Dermatology , Volume 111 (11) – Nov 1, 1975

Cromolyn Therapy in Chronic Infantile Eczema

Abstract

Abstract To the Editor.— The principal effect of cromolyn sodium (disodium cromoglycate) is believed to be inhibition of the release of chemical mediators on anaphylaxis from sensitized mast cells.1 There are some indications2,3 that cromolyn taken orally may inhibit the development of gastrointestinal manifestations of food allergy. Also, cromolyn may block the development of remote manifestations, such as urticaria, following ingestion of an offending food allergen.This report...
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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630230135031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The principal effect of cromolyn sodium (disodium cromoglycate) is believed to be inhibition of the release of chemical mediators on anaphylaxis from sensitized mast cells.1 There are some indications2,3 that cromolyn taken orally may inhibit the development of gastrointestinal manifestations of food allergy. Also, cromolyn may block the development of remote manifestations, such as urticaria, following ingestion of an offending food allergen.This report documents what is believed to be the first recorded use of cromolyn in the treatment of infantile eczema. Report of a Case.— The patient is a 6-year-old boy, whose eczema was first diagnosed at eight weeks of age. His disease was of sufficient intensity to require hospitalization on five occasions during the first 24 months of life. Intermittent therapy with oral steroids as well as nearly continuous application of topical steroids have been necessary to control his skin lesions.At five References 1. Cox JSG: Disodium cromoglycate (FPL 670) (`Intal'): A specific inhibitor of reaginic antibody-antigen mechanisms . Nature 216:1328-1329, 1967.Crossref 2. Freier S, Berger H: Disodium cromoglycate in gastrointestinal protein intolerance . Lancet 1:913-915, 1973.Crossref 3. Freier S: Pediatric gastrointestinal allergy . Clin Allergy 3:597-618, 1973.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1975

References