Abstract • Seventy-eight women with Crohn disease, each having the physical capability and opportunity to bear children, were admitted to the New York Hospital-Cornell Medical Center during a 20-year period. Forty-two pregnancies occurred. Results are suggestive of overall decreased fertility with no significant difference according to site of disease. The outcome of the pregnancies was not unlike that of the general population. Pregnancy did not exert an adverse effect on the disease itself, but termination of pregnancy was associated with relapse of Crohn disease 24% of the time. (Arch Surg 111:545-547, 1976) References 1. Mendeloff AL: The epidemiology of idiopathic inflammatory bowel disease , in Kirsner JB, Shorter RG (eds): Inflammatory Bowel Disease . Philadelphia, Lea & Febiger, 1973, p 10. 2. Abramson D, Jankelson IR, Milner FR: Pregnancy in idiopathic ulcerative colitis . Am J Obstet Gynecol 61:121-129, 1951. 3. Lockhart-Mummery HE, Morson BC: Crohn's disease of the large intestine . Gut 5:493-509, 1964.Crossref 4. Vital Statistics of the United States, 1970 . US Dept of Health, Education and Welfare, National Center for Health Statistics, 1975, vol 1, pp 1-20. 5. Colcock BP, Vansant JH: Surgical treatment of regional enteritis . N Engl J Med 262:435-439, 1960.Crossref 6. DeDombal FT, Burton IL, Goligher JC: Crohn's disease and pregnancy . Br Med J 3:550-553, 1972.Crossref 7. Fielding JF, Cooke WT: Pregnancy and Crohn's disease . Br Med J 2:76-77, 1970.Crossref 8. Hellman LM, Pritchard JA: Obstetrics . New York, Appleton-Century-Crofts Inc., 1971, p 494. 9. Chase HC: Perinatal and infant mortality in the United States and six West European countries . Am J Public Health 57:1735, 1967.Crossref 10. Crohn BB, Yarnis H, Korelitz BI: Regional ileitis complicating pregnancy . Gastroenterology 31:615-624, 1956.
Archives of Surgery – American Medical Association
Published: May 1, 1976