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Creutzfeldt-Jakob Disease in Argentina

Creutzfeldt-Jakob Disease in Argentina Abstract To the Editor.— Creutzfeldt-Jakob disease has been rarely reported below the 37th parallel,1 with very few cases from Latin America and Argentina. We report three cases diagnosed within a three-year period in a Community Hospital in Argentina. To our knowledge, there have been only six other cases reported from Argentina since 1945.2-4Diagnosis was made mainly on the basis of typical pathologic findings on CNS tissue obtained either by biopsy or autopsy. Additional support was obtained from EEG, clinical findings and evolution, neuroradiologic and laboratory studies. Report of Cases.— Case 1.—A 75-year-old woman had a one-month history of gait disturbance, mental deterioration, and right-sided hemiparesis. Symptoms steadily evolved to a full-blown dementia with incontinence, generalized seizures, and myoclonus. She died three months after clinical onset. All studies were noncontributory except the EEG, which showed disorganization and superimposed triphasic waves. Biopsy and autopsy material confirmed the diagnosis (Figure). References 1. Bobowick AR, Brody JA, Matthews MR, et al: Creutzfeldt-Jakob disease: A case control study . Am J Epidemiol 98:381-394, 1973. 2. Dimitri V, Aranovich J: Contribución al conocimiento de la degeneración corticoespinal o "seudoesclerosis espástica" de A. Jakob . Rev Neurol Arg 10:225, 1945. 3. Abiusi GRP, Scarlatti A, Ortiz de Zárate JC, et al: Segunda aportación al conocimiento de la enfermedad de Jakob-Creutzfeldt. Resumenes de trabajos. XVII Congreso Argentino de Neurología, 1976. 4. Sarcuna M, Hiskin E: Aporte a trabajos presentados sobre enfermedad de Jakob-Creutzfeldt: Nuestra experiencia en dos casos. Formas clínicas. Resumenes de trabajos. XVII Congreso Argentino de Neurología, 1976. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Creutzfeldt-Jakob Disease in Argentina

Abstract

Abstract To the Editor.— Creutzfeldt-Jakob disease has been rarely reported below the 37th parallel,1 with very few cases from Latin America and Argentina. We report three cases diagnosed within a three-year period in a Community Hospital in Argentina. To our knowledge, there have been only six other cases reported from Argentina since 1945.2-4Diagnosis was made mainly on the basis of typical pathologic findings on CNS tissue obtained either by biopsy or autopsy. Additional support was...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1979.00500390099021
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Creutzfeldt-Jakob disease has been rarely reported below the 37th parallel,1 with very few cases from Latin America and Argentina. We report three cases diagnosed within a three-year period in a Community Hospital in Argentina. To our knowledge, there have been only six other cases reported from Argentina since 1945.2-4Diagnosis was made mainly on the basis of typical pathologic findings on CNS tissue obtained either by biopsy or autopsy. Additional support was obtained from EEG, clinical findings and evolution, neuroradiologic and laboratory studies. Report of Cases.— Case 1.—A 75-year-old woman had a one-month history of gait disturbance, mental deterioration, and right-sided hemiparesis. Symptoms steadily evolved to a full-blown dementia with incontinence, generalized seizures, and myoclonus. She died three months after clinical onset. All studies were noncontributory except the EEG, which showed disorganization and superimposed triphasic waves. Biopsy and autopsy material confirmed the diagnosis (Figure). References 1. Bobowick AR, Brody JA, Matthews MR, et al: Creutzfeldt-Jakob disease: A case control study . Am J Epidemiol 98:381-394, 1973. 2. Dimitri V, Aranovich J: Contribución al conocimiento de la degeneración corticoespinal o "seudoesclerosis espástica" de A. Jakob . Rev Neurol Arg 10:225, 1945. 3. Abiusi GRP, Scarlatti A, Ortiz de Zárate JC, et al: Segunda aportación al conocimiento de la enfermedad de Jakob-Creutzfeldt. Resumenes de trabajos. XVII Congreso Argentino de Neurología, 1976. 4. Sarcuna M, Hiskin E: Aporte a trabajos presentados sobre enfermedad de Jakob-Creutzfeldt: Nuestra experiencia en dos casos. Formas clínicas. Resumenes de trabajos. XVII Congreso Argentino de Neurología, 1976.

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1979

References

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