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CREATINURIA OF INFANCY AND CHILDHOOD

CREATINURIA OF INFANCY AND CHILDHOOD The metabolism of creatine and creatinine has attracted widespread interest in recent years. Although creatinine was first recognized in 1832,1 the impetus to study its metabolism arose from the publication by Folin2 in 1904 of a simple method for its determination. Numerous investigations during the last three decades have established the constancy of the presence of creatinine in the urine and of creatine under certain normal and pathologic conditions. The regularity of the excretion of creatinine indicated that it was a waste product of the body, but the function of creatine remained an open question, although the Eggletons3 and Fiske and Subbarow4 have recently demonstrated the importance of phosphocreatine in muscle metabolism. The classic monograph by Hunter5 summarized the results of studies of creatine and creatinine up to 1928. This was supplemented by the review of Rose6 in 1933. No attempt, therefore, will be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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References (47)

Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1936.01970130039003
Publisher site
See Article on Publisher Site

Abstract

The metabolism of creatine and creatinine has attracted widespread interest in recent years. Although creatinine was first recognized in 1832,1 the impetus to study its metabolism arose from the publication by Folin2 in 1904 of a simple method for its determination. Numerous investigations during the last three decades have established the constancy of the presence of creatinine in the urine and of creatine under certain normal and pathologic conditions. The regularity of the excretion of creatinine indicated that it was a waste product of the body, but the function of creatine remained an open question, although the Eggletons3 and Fiske and Subbarow4 have recently demonstrated the importance of phosphocreatine in muscle metabolism. The classic monograph by Hunter5 summarized the results of studies of creatine and creatinine up to 1928. This was supplemented by the review of Rose6 in 1933. No attempt, therefore, will be

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jan 1, 1936

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