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Creatine Phosphokinase Activity in Central Nervous System Disorders and Infections

Creatine Phosphokinase Activity in Central Nervous System Disorders and Infections Abstract Simultaneous creatine phosphokinase (CPK) activity in cerebrospinal fluid (CSF) and serum and with other CSF constituents was determined in children with varied central nervous system (CNS) disorders and infections. Increased CPK activity in the CNS could not be associated with CSF constituents, or with serum CPK activity. Creatinine phosphokinase elevation was noted particularly in some children with first episode of febrile seizures, and follow-up of these children revealed development of chronic degenerative brain syndromes in two. Of the afebrile seizures, only patients with major motor seizures showed consistent CPK CSF elevation as did patients with CNS neoplasms. Changes in CSF CPK levels could not be correlated with mode of onset or type of infection. It is suggested that CPK activity in the CSF is associated with CNS tissue damage or nonutilization of CPK enzyme in intracellular metabolism. References 1. Lending M, Slobody LB, Mestern J: Cerebrospinal glutamic oxalacetic transaminase and lactic dehydrogenase activity in children with neurologic disorders . J Pediat 65:415-421, 1964.Crossref 2. Beaty HN, Oppenheimer S: Cerebrospinal fluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system . New Eng J Med 279:1197-1202, 1968.Crossref 3. Herschkowitz N, Cummings JW: Creatine kinase in cerebrospinal fluid . J Neurol Neurosurg Psychiat 27:247-250, 1967.Crossref 4. Neches W, Platt M: Cerebrospinal fluid LDH in 257 children . Pediatrics 41:1097-1103, 1968. 5. Sherwin AL, Norris JW, Bulcke JA: Spinal fluid creatine kinase in neurologic disease . Neurology 19:993-999, 1969.Crossref 6. Dawson D, Fine H: Creatine kinase in human tissue . Arch Neurol 16:175-180, 1967.Crossref 7. Deul DH, Van Breeman JFL: Electrophoresis of creatine phosphokinase for various organs . Clin Chim Acta 10:276-283,1964.Crossref 8. Lisak RP, Graig FA: Lack of diagnostic value of creatine phosphokinase assay in spinal fluid . JAMA 199:750-751,1967.Crossref 9. Rosalki SB: An improved procedure for serum CPK determinations . J Lab Clin Med 69:696-705,1967. 10. Wolintz A, Engel WK, Sumns TF: Isozymes of creatine phosphokinase determined by acrylamide gel electrophoresis . J Mount Sinai Hosp NY 35:174-179, 1968. 11. Eckman PL, King WM, Brienson JG: Studies of the blood brain barrier . Amer J Path 34:631-643, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Creatine Phosphokinase Activity in Central Nervous System Disorders and Infections

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1970.02100110091010
Publisher site
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Abstract

Abstract Simultaneous creatine phosphokinase (CPK) activity in cerebrospinal fluid (CSF) and serum and with other CSF constituents was determined in children with varied central nervous system (CNS) disorders and infections. Increased CPK activity in the CNS could not be associated with CSF constituents, or with serum CPK activity. Creatinine phosphokinase elevation was noted particularly in some children with first episode of febrile seizures, and follow-up of these children revealed development of chronic degenerative brain syndromes in two. Of the afebrile seizures, only patients with major motor seizures showed consistent CPK CSF elevation as did patients with CNS neoplasms. Changes in CSF CPK levels could not be correlated with mode of onset or type of infection. It is suggested that CPK activity in the CSF is associated with CNS tissue damage or nonutilization of CPK enzyme in intracellular metabolism. References 1. Lending M, Slobody LB, Mestern J: Cerebrospinal glutamic oxalacetic transaminase and lactic dehydrogenase activity in children with neurologic disorders . J Pediat 65:415-421, 1964.Crossref 2. Beaty HN, Oppenheimer S: Cerebrospinal fluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system . New Eng J Med 279:1197-1202, 1968.Crossref 3. Herschkowitz N, Cummings JW: Creatine kinase in cerebrospinal fluid . J Neurol Neurosurg Psychiat 27:247-250, 1967.Crossref 4. Neches W, Platt M: Cerebrospinal fluid LDH in 257 children . Pediatrics 41:1097-1103, 1968. 5. Sherwin AL, Norris JW, Bulcke JA: Spinal fluid creatine kinase in neurologic disease . Neurology 19:993-999, 1969.Crossref 6. Dawson D, Fine H: Creatine kinase in human tissue . Arch Neurol 16:175-180, 1967.Crossref 7. Deul DH, Van Breeman JFL: Electrophoresis of creatine phosphokinase for various organs . Clin Chim Acta 10:276-283,1964.Crossref 8. Lisak RP, Graig FA: Lack of diagnostic value of creatine phosphokinase assay in spinal fluid . JAMA 199:750-751,1967.Crossref 9. Rosalki SB: An improved procedure for serum CPK determinations . J Lab Clin Med 69:696-705,1967. 10. Wolintz A, Engel WK, Sumns TF: Isozymes of creatine phosphokinase determined by acrylamide gel electrophoresis . J Mount Sinai Hosp NY 35:174-179, 1968. 11. Eckman PL, King WM, Brienson JG: Studies of the blood brain barrier . Amer J Path 34:631-643, 1958.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Dec 1, 1970

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