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Coxsackievirus and Congenital Malformation

Coxsackievirus and Congenital Malformation To the Editor:— I have read with particular interest the communication by Brown and Evans, "Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease" (199: 183, 1967), because we have found a possible relation between the infections of coxsackievirus B during pregnancy and fetal deaths. Congenital malformations and early fetal deaths are essentially only different degrees of fetal damage. According to the data available, the greatest Bornholm epidemic caused by coxsackievirus B 3 was observed in Hungary in July and August 1958. The number of clinically manifest cases was more than 40,000. Taking into account that the manifest cases may be regarded, with some exaggeration, as complications of a much higher number of inapparent infections, the number of persons involved in the epidemic was estimated about 1 million.1 Hungary's population being approximately 10 million, the incidence was about 10%. The same percentage of pregnant women may reasonably be supposed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Coxsackievirus and Congenital Malformation

JAMA , Volume 201 (2) – Jul 10, 1967

Coxsackievirus and Congenital Malformation

Abstract



To the Editor:—
I have read with particular interest the communication by Brown and Evans, "Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease" (199: 183, 1967), because we have found a possible relation between the infections of coxsackievirus B during pregnancy and fetal deaths. Congenital malformations and early fetal deaths are essentially only different degrees of fetal damage.
According to the data available,...
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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1967.03130020088031
Publisher site
See Article on Publisher Site

Abstract

To the Editor:— I have read with particular interest the communication by Brown and Evans, "Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease" (199: 183, 1967), because we have found a possible relation between the infections of coxsackievirus B during pregnancy and fetal deaths. Congenital malformations and early fetal deaths are essentially only different degrees of fetal damage. According to the data available, the greatest Bornholm epidemic caused by coxsackievirus B 3 was observed in Hungary in July and August 1958. The number of clinically manifest cases was more than 40,000. Taking into account that the manifest cases may be regarded, with some exaggeration, as complications of a much higher number of inapparent infections, the number of persons involved in the epidemic was estimated about 1 million.1 Hungary's population being approximately 10 million, the incidence was about 10%. The same percentage of pregnant women may reasonably be supposed

Journal

JAMAAmerican Medical Association

Published: Jul 10, 1967

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