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COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19

COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19 Key PointsQuestionIs there an association between the timing of exposure to and severity of COVID-19 disease in close contacts of index patients with COVID-19? FindingsIn this cohort study of 730 index patients with a COVID-19 diagnosis and 8852 close contacts, transmission potential was greatest in the first 2 days before and 3 days after onset of symptoms in the index patient. When contacts received a diagnosis of COVID-19 infection, they were more likely to present asymptomatically if they had been exposed to an asymptomatic patient. MeaningThese results suggest that the quantity of exposure to a patient with COVID-19 may be associated with clinical presentation among close contacts who develop COVID-19. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/jamainternmed.2021.4686
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs there an association between the timing of exposure to and severity of COVID-19 disease in close contacts of index patients with COVID-19? FindingsIn this cohort study of 730 index patients with a COVID-19 diagnosis and 8852 close contacts, transmission potential was greatest in the first 2 days before and 3 days after onset of symptoms in the index patient. When contacts received a diagnosis of COVID-19 infection, they were more likely to present asymptomatically if they had been exposed to an asymptomatic patient. MeaningThese results suggest that the quantity of exposure to a patient with COVID-19 may be associated with clinical presentation among close contacts who develop COVID-19.

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Oct 23, 2021

References