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D. Ingram, D. Ingram, P. Anderson, P. Anderson, David Smith, David Smith (1972)
Countercurrent immunoelectrophoresis in the diagnosis of systemic diseases caused by Hemophilus influenzae type bThe Journal of Pediatrics, 81
P. Shackelford, Joel Campbell, R. Feigin (1974)
Countercurrent immunoelectrophoresis in the evaluation of childhood infections.The Journal of pediatrics, 85 4
R. Fallon (1976)
DIAGNOSIS AND PROGNOSIS IN PYOGENIC MENINGITISThe Lancet, 307
H. Whittle, B. Greenwood, N. Davidson, A. Tomkins, P. Tugwell, D. Warrell, A. Zalin, A. Bryceson, E. Parry, M. Brueton, M. Duggan, J. Oomen, A. Rajković (1975)
Meningococcal antigen in diagnosis and treatment of group A meningococcal infections.The American journal of medicine, 58 6
R. O'Reilly, P. Anderson, D. Ingram, G. Peter, D. Smith (1975)
Circulating polyribophosphate in Hemophilus influenzae, type b meningitis. Correlation with clinical course and antibody response.The Journal of clinical investigation, 56 4
E. Edwards, P. Muehl, R. Peckinpaugh (1972)
Diagnosis of bacterial meningitis by counterimmunoelectrophoresis.The Journal of laboratory and clinical medicine, 80 3
J. Coonrod, M. Rytel (1973)
Detection of type-specific pneumococcal antigens by counterimmunoelectrophoresis. I. Methodology and immunologic properties of pneumococcal antigens.The Journal of laboratory and clinical medicine, 81 5
W. Bradshaw, J. Parke, R. Schneerson, JohnB Robbins (1971)
Bacterial antigens cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b.Lancet, 1 7709
P. Anderson, R. Johnston, D. Smith (1972)
Human serum activities against Hemophilus influenzae, type b.The Journal of clinical investigation, 51 1
D. Granoff, G. Nankervis (1976)
Cellulitis due to Haemophilus influenzae type B. Antigenemia and antibody responses.American journal of diseases of children, 130 11
B. Ribner, G. Keusch, J. Robbins (1975)
Staphylococcus aureus Antigen in Cerebrospinal Fluid Cross-Reactive with Haemophilus influenzae Type b AntiserumAnnals of Internal Medicine, 83
Johnston RB Anderson P (1973)
Hemophilus Influenzae
Whittel HC Greenwood BM (1971)
Countercurrent immunoelectrophoresis in the diagnosis of meningococcal infectionsLancet, 2
T. Hoffman, E. Edwards (1972)
Group-specific polysaccharide antigen and humoral antibody response in disease due to Neisseria meningitidis.The Journal of infectious diseases, 126 6
R. Feigin, B. Stechenberg, M. Chang, L. Dunkle, M. Wong, H. Palkes, P. Dodge, H. Davis (1976)
Prospective evaluation of treatment of Hemophilus influenzae meningitis.The Journal of pediatrics, 88 4 Pt 1
E. Wald, M. Levine (1976)
Frequency of detection of Hemophilus influenzae type b capsular polysaccharide in infants and children with pneumonia.Pediatrics, 57 2
E. Edwards (1974)
Immunological investigations of meningococcal disease. II. Some characteristics of group C antigen of Neisseria meningitidis in the sera of patients with fulminant meningococcemia.The Journal of infectious diseases, 129 5
P. Anderson, G. Peter, R. Johnston, L. Wetterlow, D. Smith (1972)
Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.The Journal of clinical investigation, 51 1
R. Feigin, M. Wong, P. Shackelford, B. Stechenberg, L. Dunkle, S. Kaplan (1976)
Countercurrent immunoelectrophoresis of urine as well as of CSF and blood for diagnosis of bacterial meningitis.The Journal of pediatrics, 89 5
J. Coonrod, M. Rytel (1972)
DETERMINATION OF ÆTIOLOGY OF BACTERIAL MENINGITIS BY COUNTERIMMUNOELECTROPHORESISThe Lancet, 299
Edward Smith, D. Ingram (1975)
Counterimmunoelectrophoresis in Hemophilus influenzae type b epiglottitis and pericarditis.The Journal of Pediatrics, 86
D. Granoff, G. Nankervis (1977)
Circulating capsular antigen in infant rats infected with Haemophilus influenzae type b.The Journal of infectious diseases, 136 2
Abstract • Sixty-one patients with Haemophilus influenzae type b infection were studied for the presence of capsular antigen by countercurrent immunoelectrophoresis. Antigen was present (≥10 ng/ml) in admission blood or cerebrospinal fluid samples of 92% of patients with meningitis and could be detected in blood for up to 17 days. Despite bacterial cultures reverting to negative, detectable antigen was present at two to three days in 75% of patients, and at four to five days in 54%. No difference in persistence of antigen was found in patients with meningitis who were receiving ampicillin or chloramphenicol. Antigenemia was less frequently detected in patients without meningitis who were studied at the time of hospital admission (7/22, P <.01). However, antigen was detected 24 hours after onset of therapy in one initially negative patient; in four other patients who lacked circulating antigen, bone or joint aspirates or nasopharyngeal secretions were antigen positive. Circulating antigen was less frequently detected in individuals 2 years of age or older and those with convalescent hemagglutinating titers greater than or equal to 1:4. We propose that older patients may develop early anticapsular antibody responses to their infection that interfere with detection of circulating antigen. (Am J Dis Child 131:1357-1362, 1977) References 1. O'Reilly RJ, Anderson P, Ingram DL, et al: Circulating polyribophosphate in Hemophilus influenzae, type b meningitis: Correlation with clinical course and antibody response . J Clin Invest 56:1012-1022, 1975.Crossref 2. Edwards EA, Muehl PM, Peckinpaugh RO: Diagnosis of bacterial meningitis by counterimmunoelectrophoresis . J Lab Clin Med 80:449-454, 1972. 3. Coonrod JD, Rytel MW: Determination of aetiology of bacterial meningitis by counterimmunoelectrophoresis . Lancet 1:1154-1157, 1972.Crossref 4. Ingram DL, Anderson P, Smith DH: Countercurrent immunoelectrophoresis in the diagnosis of systemic diseases caused by Hemophilus influenzae type b . J Pediatr 81:1156-1159, 1972.Crossref 5. Shackelford P, Campbell J, Feigin RD: Countercurrent immunoelectrophoresis in the evaluation of childhood infections . J Pediatr 85:478-481, 1974.Crossref 6. Feigin RD, Stechenberg BW, Chang MJ, et al: Prospective evaluation of treatment of Hemophilus influenzae meningitis . J Pediatr 88:542-548, 1976.Crossref 7. Smith EWP, Ingram DL: Counterimmunoelectrophoresis in Hemophilus influenzae type b epiglottitis and pericarditis . J Pediatr 86:571-573, 1975.Crossref 8. Granoff DM, Nankervis GA: Cellulitus due to Haemophilus influenzae type b: Antigenemia and antibody responses . Am J Dis Child 130:1211-1214, 1976. 9. Anderson P, Peter G, Johnston RB, et al: Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b . J Clin Invest 51:39-44, 1972.Crossref 10. Anderson P, Johnston RB, Smith DH: Human serum activities against Hemophilus influenzae, type b . J Clin Invest 51:31-38, 1972.Crossref 11. Anderson P, Johnston RB, Smith DH: Methodology in detection of human serum antibodies to Hemophilus Influenzae, type b , in Sell SHW, Karzon D (eds): Hemophilus Influenzae . Nashville, Tenn, Vanderbilt University Press, 1973, pp 87-94. 12. Coonrod DJ, Rytel MW: Detection of typespecific pneumococcal antigens by counterimmunoelectrophoresis: 1. Methodology and immunologic properties of pneumococcal antigens . J Lab Clin Med 81:770-777, 1973. 13. Greenwood BM, Whittel HC, Dominic-Rajkovic O: Countercurrent immunoelectrophoresis in the diagnosis of meningococcal infections . Lancet 2:519-521, 1971.Crossref 14. Hoffman TA, Edwards EA: Group-specific polysaccharide antigen and humoral antibody response in disease due to Neisseria meningitidis . J Infect Dis 126:636-644, 1972.Crossref 15. Edwards EA: Immunological investigations of meningococcal disease: II. Some charac teristics of group C antigen of Neisseria meningitidis in the sera of patients with fulminant meningococcemia . J Infect Dis 129:538-544, 1974.Crossref 16. Whittle HC, Greenwood BM, Davidson N, et al: Meningococcal antigen in diagnosis and treatment of group A meningococcal infections . Am J Med 58:823-828, 1975.Crossref 17. Diagnosis and prognosis in pyogenic meningitis , editorial. Lancet 1:1277-1278, 1976. 18. Feigin RD, Wong M, Shackelford PG, et al: Countercurrent immunoelectrophoresis of urine as well as of CSF and blood for diagnosis of bacterial meningitis . J Pediatr 89:773-775, 1976.Crossref 19. Wald ER, Levine MM: Frequency of detection of Hemophilus influenzae type b capsular polysaccharide in infants and children with pneumonia . Pediatrics 57:266-268, 1976. 20. Granoff D, Nankervis GA: Circulating capsular antigen in infant rats infected with Hemophilus influenzae type b . J Infect Dis 136:292-296, 1977.Crossref 21. Bradshaw MW, Parke JC, Schneerson R, et al: Bacterial antigens cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b . Lancet 1:1095-1096, 1971.Crossref 22. Ribner B, Keusch GT: Staphylococcus aureus antigen in cerebrospinal fluid cross-reactive with Haemophilus influenzae type b antiserum . Ann Intern Med 83:370-371, 1975.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Dec 1, 1977
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