Abstract The marked beneficial effect of systemic corticosteroids on the vision of ten patients with optic nerve involvement associated with thyroid dysfunction is reported. The drugs must be administered in sufficient dosage and often for long periods of time. Therefore, the complications of corticosteroid therapy may occur, and they must be given as a calculated risk. This risk would appear to be justified when vision is threatened. References 1. Scheie, H.G., et al: Adrenocorticotropic Hormone (ACTH) and Cortisone in Ophthalmology , Arch Ophthal 45:301, 1951.Crossref 2. Woods, A.C.: The Present Status of ACTH and Cortisone in Clinical Ophthalmology , Amer J Ophthal 34:945, 1951. 3. Fitzgerald, J.R., et al: Early Clinical Results of ACTH and Cortisone Treatment of Ocular Disease , Arch Ophthal 45:320, 1951.Crossref 4. Igersheimer, J.: Visual Changes in Progressive Exophthalmos , Arch Ophthal 53:94, 1955.Crossref 5. Brown, J., et al: Adrenal Steroid Therapy of Severe Infiltrative Ophthalmopathy of Graves' Disease , Amer J Med 34:786, 1963.Crossref 6. Werner, S.C.: Prednisone in Emergency Treatment of Malignant Exophthalmos , Lancet 1:1004 ( (May 7) ) 1966.Crossref 7. Day, R.M., and Carroll, F.D.: Optic Nerve Involvement Associated With Thyroid Dysfunction , Arch Ophthal 67:289, 1962.Crossref 8. Garber, M.I.: Methylprednisolone in the Treatment of Exophthalmos , Lancet 1:958 ( (April 30) ) 1966.Crossref 9. Bjorneboe, M.; Fischel, E.E.; and Stoerk, H.C.: The Effect of Cortisone and Adrenocorticotrophic Hormone on the Concentration of Circulating Antibody , J Exp Med 93:37, 1951.Crossref 10. Werner, S.C.; Hamilton, H.; and Frantz, V.K.: Proceedings of the 2nd Clinical ACTH Conference , Philadelphia: Blakiston Company, 1951, p 521. 11. French, L.A.: The Use of Steroids in the Treatment of Cerebral Edema , Bull NY Acad Med 42:301, 1966. 12. Kroll, A.J., and Casten, V.G.: Dysthroid Exophthalmos , Arch Ophthal 76:205, 1966.Crossref 13. Long, J.C., and Ellis, G.D.: Temporal Decompression of the Orbit for Thyroid Exophthalmos , Amer J Ophthal 62:1089, 1966.
Archives of Ophthalmology – American Medical Association
Published: Mar 1, 1968