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Corticosteroid Therapy for Pneumocystis carinii Pneumonia in Children With Human Immunodeficiency Virus Infection

Corticosteroid Therapy for Pneumocystis carinii Pneumonia in Children With Human Immunodeficiency... Abstract Bye and coworkers1 have provided extremely valuable data on the efficacy of corticosteroid therapy in treating Pneumocystis carinii pneumonia (PCP) in children infected with human immunodeficiency virus. However, I believe that some of the statistical analyses shown in their Table are incorrect and that the errors have influenced some of their conclusions. Using their data, I performed χ2 analysis using Epi Info, Version 5,2 the statistical software package distributed by the Centers for Disease Control and Prevention, Atlanta, Ga. The results are shown in the Table. This reanalysis shows that there is not a significant difference in the incidence of adverse reactions to a combination of trimethoprim and sulfamethoxazole between the two groups or a difference in the proportion of patients who presented with PCP as the initial manifestation of human immunodeficiency virus infection. The reduction in the proportion of patients requiring mechanical ventilation is of marginal References 1. Bye MR, Cairns-Bazarian AM, Ewig JM. Markedly reduced mortality associated with corticosteroid therapy of Pneumocystis carinii pneumonia in children with acquired immunodeficiency syndrome . Arch Pediatr Adolesc Med . 1994;148:638-641.Crossref 2. Dean AG, Dean JA, Burton AH, Dicker RC. Epi Info, Version 5: A Word Processing, Database, and Statistics Program for Epidemiology on Microcomputers . Stone Mountain, Ga: USD Inc; 1990. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pediatrics & Adolescent Medicine American Medical Association

Corticosteroid Therapy for Pneumocystis carinii Pneumonia in Children With Human Immunodeficiency Virus Infection

Corticosteroid Therapy for Pneumocystis carinii Pneumonia in Children With Human Immunodeficiency Virus Infection

Abstract

Abstract Bye and coworkers1 have provided extremely valuable data on the efficacy of corticosteroid therapy in treating Pneumocystis carinii pneumonia (PCP) in children infected with human immunodeficiency virus. However, I believe that some of the statistical analyses shown in their Table are incorrect and that the errors have influenced some of their conclusions. Using their data, I performed χ2 analysis using Epi Info, Version 5,2 the statistical software package distributed by the...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
1072-4710
eISSN
1538-3628
DOI
10.1001/archpedi.1995.02170210104021
Publisher site
See Article on Publisher Site

Abstract

Abstract Bye and coworkers1 have provided extremely valuable data on the efficacy of corticosteroid therapy in treating Pneumocystis carinii pneumonia (PCP) in children infected with human immunodeficiency virus. However, I believe that some of the statistical analyses shown in their Table are incorrect and that the errors have influenced some of their conclusions. Using their data, I performed χ2 analysis using Epi Info, Version 5,2 the statistical software package distributed by the Centers for Disease Control and Prevention, Atlanta, Ga. The results are shown in the Table. This reanalysis shows that there is not a significant difference in the incidence of adverse reactions to a combination of trimethoprim and sulfamethoxazole between the two groups or a difference in the proportion of patients who presented with PCP as the initial manifestation of human immunodeficiency virus infection. The reduction in the proportion of patients requiring mechanical ventilation is of marginal References 1. Bye MR, Cairns-Bazarian AM, Ewig JM. Markedly reduced mortality associated with corticosteroid therapy of Pneumocystis carinii pneumonia in children with acquired immunodeficiency syndrome . Arch Pediatr Adolesc Med . 1994;148:638-641.Crossref 2. Dean AG, Dean JA, Burton AH, Dicker RC. Epi Info, Version 5: A Word Processing, Database, and Statistics Program for Epidemiology on Microcomputers . Stone Mountain, Ga: USD Inc; 1990.

Journal

Archives of Pediatrics & Adolescent MedicineAmerican Medical Association

Published: Aug 1, 1995

References