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Correlation of the Vasoconstrictor Assay and Clinical Activity in Psoriasis-Reply

Correlation of the Vasoconstrictor Assay and Clinical Activity in Psoriasis-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.— The "area-under-the-curve" method is a perfectly rational one, reported by others. The main problem is to correlate vasoconstriction data with clinical data, and this we have done with our method (16 hours under a guard, one reading). Other methods will have to be checked with clinical data to see if they are predictive. Our data are the most comprehensive for a single method. It would be very interesting to look at alclometasone and hydrocortisone valerate with the area-under-the-curve method.Other workers have shown that extemporaneous formulations are unpredictable in their clinical activity, and we avoid them for that reason.Triamcinolone acetonide is available in many different ointment, cream, and lotion vehicles in this country. The old conventional ointments were more biologically active than the creams, but there have been so many alterations, especially in the creams, that one can no longer set any predictive rules for ointments or creams http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Correlation of the Vasoconstrictor Assay and Clinical Activity in Psoriasis-Reply

Correlation of the Vasoconstrictor Assay and Clinical Activity in Psoriasis-Reply

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.— The "area-under-the-curve" method is a perfectly rational one, reported by others. The main problem is to correlate vasoconstriction data with clinical data, and this we have done with our method (16 hours under a guard, one reading). Other methods will have to be checked with clinical data to see if they are predictive. Our...
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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660090019003
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.— The "area-under-the-curve" method is a perfectly rational one, reported by others. The main problem is to correlate vasoconstriction data with clinical data, and this we have done with our method (16 hours under a guard, one reading). Other methods will have to be checked with clinical data to see if they are predictive. Our data are the most comprehensive for a single method. It would be very interesting to look at alclometasone and hydrocortisone valerate with the area-under-the-curve method.Other workers have shown that extemporaneous formulations are unpredictable in their clinical activity, and we avoid them for that reason.Triamcinolone acetonide is available in many different ointment, cream, and lotion vehicles in this country. The old conventional ointments were more biologically active than the creams, but there have been so many alterations, especially in the creams, that one can no longer set any predictive rules for ointments or creams

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1985

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