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Corpus Luteum Hemorrhagicum: An Unusual Complication of Anticoagulant Therapy

Corpus Luteum Hemorrhagicum: An Unusual Complication of Anticoagulant Therapy Abstract Hemorrhagic complications of oral anticoagulant therapy are well known. The purpose of this communication is to report an unusual and potentially life-threatening complication of long-term anticoagulant therapy that, as far as we know, has not been previously reported in the pediatric literature. Report of a Case.—A 17-year-old girl was admitted to the hospital because of a rapidly decreasing hematocrit reading and abdominal pain. She was known to have rheumatic heart disease since age 7 years, and at 13 years of age, her mitral valve was replaced with a Björk-Shiley artificial valve. Postoperatively, she was given daily penicillin G potassium and warfarin sodium. Two months prior to admission, the patient had a transient episode of cerebral ischemia after poor compliance with her warfarin regimen. Her warfarin dose was increased, and she subsequently did well, with prothrombin times that were 2½ times control values. One month prior to admission, she had References 1. Gurewich V, Thomas D: Massive intraperitoneal hemorrhage from a ruptured corpus luteum . N Engl J Med 263:909-910, 1960.Crossref 2. Weseley AC, Neustadter MI, Levine W: Massive intraperitoneal hemorrhage of ovarian follicular origin during anticoagulant therapy . Am J Obstet Gynecol 73:683-685, 1957. 3. Rosenthal AH: Rupture of the corpus luteum, including four cases of massive intraperitoneal hemorrhage . Am J Obstet Gynecol 79:1008-1011, 1960. 4. Krause JR, Amores R: Massive intraperitoneal hemorrhage from ruptured corpus luteum during anticoagulant therapy . South Med J 69:1220-1221, 1976.Crossref 5. Perlman JA, Barnes AB, Demirjian Z: Corpus luteum hemorrhages complicating chronic anticoagulation . Obstet Gynecol 49( (suppl) ):20-21, 1977. 6. Wong K, Gillett PG: Recurrent hemorrhage from corpus luteum during anticoagulant therapy . Can Med Assoc J 116:388-390, 1977. 7. Lee RA, Kazmier FJ: Ovarian hematoma complicating anticoagulant therapy . Mayo Clin Proc 52:19-23, 1977. 8. Semchyshyn S, Zuspan F: Ovarian hemorrhage due to anticoagulants . Am J Obstet Gynecol 131:837-844, 1978. 9. Kakkar VV, Field ES, Nicolaides AN, et al: Low doses of heparin in prevention of deep-vein thrombosis . Lancet 2:669-671, 1971.Crossref 10. Kakkar VV, Corrigan TP, Fossard DP: Prevention of fatal postoperative pulmonary embolism by low doses of heparin: An international multicentre trial . Lancet 2:45-51, 1975. 11. Goldzieher JW, Dozier TS: Oral contraceptives and thromboembolism: A reassessment . Am J Obstet Gynecol 123:878-914, 1975. 12. Sartwell PE, Masi AT, Arthur FG, et al: Thromboembolism and oral contraceptives: An epidemiologic case control study . Am J Epidemiol 90:365-380, 1969. 13. Coon WW, Willis PW III, Keller JB: Venous thromboembolism and other venous disease in the Tecumseh Community Health Study . Circulation 48:839-846, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Corpus Luteum Hemorrhagicum: An Unusual Complication of Anticoagulant Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130170073026
Publisher site
See Article on Publisher Site

Abstract

Abstract Hemorrhagic complications of oral anticoagulant therapy are well known. The purpose of this communication is to report an unusual and potentially life-threatening complication of long-term anticoagulant therapy that, as far as we know, has not been previously reported in the pediatric literature. Report of a Case.—A 17-year-old girl was admitted to the hospital because of a rapidly decreasing hematocrit reading and abdominal pain. She was known to have rheumatic heart disease since age 7 years, and at 13 years of age, her mitral valve was replaced with a Björk-Shiley artificial valve. Postoperatively, she was given daily penicillin G potassium and warfarin sodium. Two months prior to admission, the patient had a transient episode of cerebral ischemia after poor compliance with her warfarin regimen. Her warfarin dose was increased, and she subsequently did well, with prothrombin times that were 2½ times control values. One month prior to admission, she had References 1. Gurewich V, Thomas D: Massive intraperitoneal hemorrhage from a ruptured corpus luteum . N Engl J Med 263:909-910, 1960.Crossref 2. Weseley AC, Neustadter MI, Levine W: Massive intraperitoneal hemorrhage of ovarian follicular origin during anticoagulant therapy . Am J Obstet Gynecol 73:683-685, 1957. 3. Rosenthal AH: Rupture of the corpus luteum, including four cases of massive intraperitoneal hemorrhage . Am J Obstet Gynecol 79:1008-1011, 1960. 4. Krause JR, Amores R: Massive intraperitoneal hemorrhage from ruptured corpus luteum during anticoagulant therapy . South Med J 69:1220-1221, 1976.Crossref 5. Perlman JA, Barnes AB, Demirjian Z: Corpus luteum hemorrhages complicating chronic anticoagulation . Obstet Gynecol 49( (suppl) ):20-21, 1977. 6. Wong K, Gillett PG: Recurrent hemorrhage from corpus luteum during anticoagulant therapy . Can Med Assoc J 116:388-390, 1977. 7. Lee RA, Kazmier FJ: Ovarian hematoma complicating anticoagulant therapy . Mayo Clin Proc 52:19-23, 1977. 8. Semchyshyn S, Zuspan F: Ovarian hemorrhage due to anticoagulants . Am J Obstet Gynecol 131:837-844, 1978. 9. Kakkar VV, Field ES, Nicolaides AN, et al: Low doses of heparin in prevention of deep-vein thrombosis . Lancet 2:669-671, 1971.Crossref 10. Kakkar VV, Corrigan TP, Fossard DP: Prevention of fatal postoperative pulmonary embolism by low doses of heparin: An international multicentre trial . Lancet 2:45-51, 1975. 11. Goldzieher JW, Dozier TS: Oral contraceptives and thromboembolism: A reassessment . Am J Obstet Gynecol 123:878-914, 1975. 12. Sartwell PE, Masi AT, Arthur FG, et al: Thromboembolism and oral contraceptives: An epidemiologic case control study . Am J Epidemiol 90:365-380, 1969. 13. Coon WW, Willis PW III, Keller JB: Venous thromboembolism and other venous disease in the Tecumseh Community Health Study . Circulation 48:839-846, 1973.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1980

References

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