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Corneal Xerophthalmia-Reply

Corneal Xerophthalmia-Reply Abstract In Reply. —Keratomalacia in the absence of conjunctival xerosis from sudden deterioration of vitamin A status was indeed reported by McLaren et al1 in 1966, as referenced in my article. Their report was certainly not the first. Similar cases were reported by Stephenson2 in 1910 and by Blegvad3 in 1924. Additional references are compiled elsewhere.4The two cases detailed in the 1976 report of Baum and Rao5 may represent the same phenomenon, but are too atypical for firm conclusions in this regard. His first patient had an initial serum vitamin A level of 43 μg/dL, well within the normal range.5,6 The second patient's condition continued to deteriorate long after vitamin A treatment was started and vitamin A levels were within normal limits. References 1. McLaren DS, Oomen HAPC, Escapini H: Ocular manifestations of vitamin A deficiency in man . Bull WHO 1966;34:357-361. 2. Stephenson S: On sloughing corneae in infants: An account based upon the records of 31 cases . Ophthalmoscope 1910;8:782-818. 3. Blegvad O: Xerophthalmia, keratomalacia and xerosis conjunctivae . Am J Ophthalmol 1924;7:89-117. 4. Sommer A: Nutritional Blindness: Xerophthalmia and Keratomalacia . New York, Oxford University Press, 1982, pp 48-54. 5. Baum JL, Rao G: Keratomalacia in the cachectic hospitalized patient . Am J Ophthalmol 1976;82:435-438. 6. Vitamin A deficiency and xerophthalmia: Report of a joint USAID/WHO meeting. WHO Tech Rep Ser, 1976, p 27. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Corneal Xerophthalmia-Reply

Archives of Ophthalmology , Volume 101 (2) – Feb 1, 1983

Corneal Xerophthalmia-Reply

Abstract

Abstract In Reply. —Keratomalacia in the absence of conjunctival xerosis from sudden deterioration of vitamin A status was indeed reported by McLaren et al1 in 1966, as referenced in my article. Their report was certainly not the first. Similar cases were reported by Stephenson2 in 1910 and by Blegvad3 in 1924. Additional references are compiled elsewhere.4The two cases detailed in the 1976 report of Baum and Rao5 may represent the same phenomenon, but are too atypical for firm...
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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1983.01040010305027
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply. —Keratomalacia in the absence of conjunctival xerosis from sudden deterioration of vitamin A status was indeed reported by McLaren et al1 in 1966, as referenced in my article. Their report was certainly not the first. Similar cases were reported by Stephenson2 in 1910 and by Blegvad3 in 1924. Additional references are compiled elsewhere.4The two cases detailed in the 1976 report of Baum and Rao5 may represent the same phenomenon, but are too atypical for firm conclusions in this regard. His first patient had an initial serum vitamin A level of 43 μg/dL, well within the normal range.5,6 The second patient's condition continued to deteriorate long after vitamin A treatment was started and vitamin A levels were within normal limits. References 1. McLaren DS, Oomen HAPC, Escapini H: Ocular manifestations of vitamin A deficiency in man . Bull WHO 1966;34:357-361. 2. Stephenson S: On sloughing corneae in infants: An account based upon the records of 31 cases . Ophthalmoscope 1910;8:782-818. 3. Blegvad O: Xerophthalmia, keratomalacia and xerosis conjunctivae . Am J Ophthalmol 1924;7:89-117. 4. Sommer A: Nutritional Blindness: Xerophthalmia and Keratomalacia . New York, Oxford University Press, 1982, pp 48-54. 5. Baum JL, Rao G: Keratomalacia in the cachectic hospitalized patient . Am J Ophthalmol 1976;82:435-438. 6. Vitamin A deficiency and xerophthalmia: Report of a joint USAID/WHO meeting. WHO Tech Rep Ser, 1976, p 27.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1983

References