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Corneal Toxicity From Acidic Vancomycin Solution

Corneal Toxicity From Acidic Vancomycin Solution Abstract To the Editor. —Pflugfelder and Murchison1 reported a case of corneal toxicity with a 12-hour collagen shield soaked in tobramycin sulfate (40 mg/mL), vancomycin hydrochloride (50 mg/mL), and dexamethasone sodium phosphate (4 mg/mL) in the January 1992 issue of the Archives. When reconstituted in water, vancomycin has a pH of 2.5 to 4.5. Topical application of a solution with such a low pH to the cornea is toxic, whether or not a collagen shield is used. A collagen shield soaked in anything with a pH of 2.5 is extremely toxic to the cornea. I have seen several cases of corneal toxicity from topical application of acidic vancomycin solution alone. A buffer should be used to raise the pH to an acceptable level whenever vancomycin eye drops are used. References 1. Pflugfelder SC, Murchison JF. Corneal toxicity with an antibiotic/steroidsoaked collagen shield . Arch Ophthalmol . 1992;110:20.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Corneal Toxicity From Acidic Vancomycin Solution

Archives of Ophthalmology , Volume 111 (1) – Jan 1, 1993

Corneal Toxicity From Acidic Vancomycin Solution

Abstract

Abstract To the Editor. —Pflugfelder and Murchison1 reported a case of corneal toxicity with a 12-hour collagen shield soaked in tobramycin sulfate (40 mg/mL), vancomycin hydrochloride (50 mg/mL), and dexamethasone sodium phosphate (4 mg/mL) in the January 1992 issue of the Archives. When reconstituted in water, vancomycin has a pH of 2.5 to 4.5. Topical application of a solution with such a low pH to the cornea is toxic, whether or not a collagen shield is used. A collagen shield...
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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1993.01090010020003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Pflugfelder and Murchison1 reported a case of corneal toxicity with a 12-hour collagen shield soaked in tobramycin sulfate (40 mg/mL), vancomycin hydrochloride (50 mg/mL), and dexamethasone sodium phosphate (4 mg/mL) in the January 1992 issue of the Archives. When reconstituted in water, vancomycin has a pH of 2.5 to 4.5. Topical application of a solution with such a low pH to the cornea is toxic, whether or not a collagen shield is used. A collagen shield soaked in anything with a pH of 2.5 is extremely toxic to the cornea. I have seen several cases of corneal toxicity from topical application of acidic vancomycin solution alone. A buffer should be used to raise the pH to an acceptable level whenever vancomycin eye drops are used. References 1. Pflugfelder SC, Murchison JF. Corneal toxicity with an antibiotic/steroidsoaked collagen shield . Arch Ophthalmol . 1992;110:20.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1993

References

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