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Corneal Lesions Produced in Rabbits by an Extract of Fusarium Moniliforme

Corneal Lesions Produced in Rabbits by an Extract of Fusarium Moniliforme Abstract Mycotic ulcerative keratitis was first described by Leber in 1879.1 A number of case reports followed over the next few years. Few cases were reported from 1915 to 1950, but many cases have been reported since 1950. These cases apparently were associated with the widespread use of corticosteroid and antibiotic preparations.2-5 Mycokeratitis can be reproduced experimentally in animals, particularly with concomitant corticosteroid administration.6-9 The necrosis and ulceration which occur in this lesion have suggested that a substance or substances elaborated by the fungus may play an important role in pathogenesis.3,8 Since the cornea is approximately 85% collagen and 15% mucopolysaccharide in composition, it has been postulated that the fungal substance is proteolytic in nature. Burda and Fisher10 found that an extract of Cephalosporium species would produce corneal destruction in two to four hours, with opacification, liquefaction, and ulceration. In vitro studies indicated that a proteinase References 1. Leber, T.: Keratomycosis Aspergillina als Ursache von Hypopyonkeratitis , Graefe Arch Ophthal 25:285-301, 1879.Crossref 2. Zimmerman, L. E.: Mycotic Keratitis , Lab Invest 11:1151-1160, 1962. 3. Gingrick, W. D.: Keratomycosis , JAMA 179:602-608, 1962.Crossref 4. Chick, E. W., and Conant, N. F.: Mycotic Ulcerative Keratitis: Review of 148 Cases From the Literature , Invest Ophthal 1:419, 1962. 5. Fungal Corneal Ulcer Editorial , JAMA 179:649-650, 1962.Crossref 6. Ley, A. P.: Experimental Fungus Infections of the Cornea: Preliminary Report , Amer J Ophthal 42:59-70, 1956. 7. Mitsui, Y., and Hanabusa, J.: Corneal Infection After Cortisone Therapy , Brit J Ophthal 39:244-250, 1955.Crossref 8. Burda, C. D., and Fisher, E., Jr.: Use of Cortisone in Establishing Experimental Fungal Keratitis in Rats: Preliminary Report , Amer J Ophthal 48:330-335, 1959. 9. Chick, E. W.: Studies on Pathogenesis of Mycotic Keratitis, to be published. 10. Burda, C. D., and Fisher, E., Jr.; Corneal Destruction by Extracts of Cephalosporium Mycelium , Amer J Ophthal 50:926-936, 1960. 11. Anderson, B., Jr., and Chick, E. W.: Mycokeratitis: Treatment of Fungal Corneal Ulcers With Amphotericin B and Mechanical Debridement , Southern Med J 56:270-274, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Corneal Lesions Produced in Rabbits by an Extract of Fusarium Moniliforme

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Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1964.00970020346012
Publisher site
See Article on Publisher Site

Abstract

Abstract Mycotic ulcerative keratitis was first described by Leber in 1879.1 A number of case reports followed over the next few years. Few cases were reported from 1915 to 1950, but many cases have been reported since 1950. These cases apparently were associated with the widespread use of corticosteroid and antibiotic preparations.2-5 Mycokeratitis can be reproduced experimentally in animals, particularly with concomitant corticosteroid administration.6-9 The necrosis and ulceration which occur in this lesion have suggested that a substance or substances elaborated by the fungus may play an important role in pathogenesis.3,8 Since the cornea is approximately 85% collagen and 15% mucopolysaccharide in composition, it has been postulated that the fungal substance is proteolytic in nature. Burda and Fisher10 found that an extract of Cephalosporium species would produce corneal destruction in two to four hours, with opacification, liquefaction, and ulceration. In vitro studies indicated that a proteinase References 1. Leber, T.: Keratomycosis Aspergillina als Ursache von Hypopyonkeratitis , Graefe Arch Ophthal 25:285-301, 1879.Crossref 2. Zimmerman, L. E.: Mycotic Keratitis , Lab Invest 11:1151-1160, 1962. 3. Gingrick, W. D.: Keratomycosis , JAMA 179:602-608, 1962.Crossref 4. Chick, E. W., and Conant, N. F.: Mycotic Ulcerative Keratitis: Review of 148 Cases From the Literature , Invest Ophthal 1:419, 1962. 5. Fungal Corneal Ulcer Editorial , JAMA 179:649-650, 1962.Crossref 6. Ley, A. P.: Experimental Fungus Infections of the Cornea: Preliminary Report , Amer J Ophthal 42:59-70, 1956. 7. Mitsui, Y., and Hanabusa, J.: Corneal Infection After Cortisone Therapy , Brit J Ophthal 39:244-250, 1955.Crossref 8. Burda, C. D., and Fisher, E., Jr.: Use of Cortisone in Establishing Experimental Fungal Keratitis in Rats: Preliminary Report , Amer J Ophthal 48:330-335, 1959. 9. Chick, E. W.: Studies on Pathogenesis of Mycotic Keratitis, to be published. 10. Burda, C. D., and Fisher, E., Jr.; Corneal Destruction by Extracts of Cephalosporium Mycelium , Amer J Ophthal 50:926-936, 1960. 11. Anderson, B., Jr., and Chick, E. W.: Mycokeratitis: Treatment of Fungal Corneal Ulcers With Amphotericin B and Mechanical Debridement , Southern Med J 56:270-274, 1963.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1964

References