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EDITORIAL The Possible Therapeutic Use of Limbal Stem Cell Transplantation PATHOPHYSIOLOGY OF CORNEAL ever, several lines of evidence now implicate an epithe- DYSTROPHIES OF EPITHELIAL GENESIS lial genesis. For example, the early stages of granular dys- trophy can show fine epithelial and subepithelial deposits. Classification of the primary corneal dystrophies has un- A superficial variant of granular dystrophy has also been til now been based on biomicroscopic and pathologic fea- described, with onset in childhood, subepithelial and su- tures. Depending on the location of dystrophic depos- perficial stromal deposits, and a more severe clinical 9,10 its, the main anatomic groupings have been epithelial and course. This may represent a homozygous form of dis- subepithelial dystrophies, dystrophies primarily affect- ease. In addition, graft recurrences following penetrat- ing the Bowman layer, stromal dystrophies, and endo- ing keratoplasty (PK) for granular dystrophy occur ini- thelial dystrophies. tially in the subepithelial region. Only later is the stroma Recent advances in our understanding of the affected. In the adult human and rabbit cornea, the BIGH3 molecular genetics and pathophysiology of certain cor- gene is strongly expressed by corneal epithelial cells but 13,14 neal dystrophies proffer a paradigm shift regarding the not by keratocytes. Keratoepithelin
JAMA Ophthalmology – American Medical Association
Published: Jan 1, 2001
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