Abstract Hydroquinone is a reducing agent widely used in photography. The clinical picture and course of the conjunctival and corneal changes in workers employed in the manufacture of hydroquinone have been well described.1-10 The early conjunctival pigmentation has been studied histologically also, and was found to be the result of finely granular and globular brown material distributed within and between cells, mainly in the basal layer of the epithelium and in the episcleral tissue.1,2 To my knowledge, no histopathologic report is available on the corneal alterations that develop later in the disease. It is the purpose of this study to describe these histopathologic changes as observed in three corneal buttons obtained by keratoplasty. Material and Methods The corneal tissue from case 1 and case 2 was obtained from the University Eye Hospital in Hamburg, Germany, while that from case 3 was contributed by Drs. B. Anderson, Sr., and A. References 1. Velhagen, K.: Chinonverfärbung der Lidspaltenzone als Gewerbekrankheit in der Hydroquinonfabrikation , Klin Mbl Augenheilk 86:739-752, 1931. 2. Sterner, J.H.; Oglesby, F.L.; and Anderson, B.: Quinone Vapors and Their Harmful Effects , J Industr Hyg 29:60-84, 1947. 3. Anderson, B.: Corneal and Conjunctival Pigmentation Among Workers Engaged in the Manufacture of Hydroquinone , Arch Ophthal 38:812-826, 1947.Crossref 4. Krahnstöver, M.: Schwere Spätschädigung eines Auges durch Hydroquinone , Klin Mbl Augenheilk 126:340-341, 1955. 5. Anderson, B., and Oglesby, A.B.: Corneal Changes from Quinone-Hydroquinone Exposure , Arch Ophthal 59:495-501, 1958.Crossref 6. Duke-Elder, W.S.: Textbook of Ophthalmology , vol 6, London: Kimpton, 1954, pp 6684-6687. 7. Miller, S.J.: Ocular Ochronosis , Trans Ophthal Soc UK 74:349-366, 1954. 8. Straub, M.W.: Alterations de l'oeil humain par l'hydroquinone , Bull Soc Franc Ophtal 72:231-235, 1959. 9. Gernet, H.: Late Sequelae of Hydroquinone Exposure of the Cornea , Bull Soc Franc Ophtal 75:527-529, 1962 10. abstracted, Amer J Ophthal 58: 328-329, 1964. 11. Grant, W.M.: Toxicology of the Eye , Springfield, Ill: Charles C Thomas, 1962, p 457 ff. 12. Gass, J.D.: The Iron Lines of the Superficial Cornea , Arch Ophthal 71:348-358, 1964.Crossref 13. Blobner, F.: Hornhautverfärbung durch ein Adrenalin-Praeparat , Klin Mbl Augenheilk 100:758-763, 1938. 14. Ferry, A.P., and Zimmerman, L.E.: Black Cornea: A Complication of Topical Use of Epinephrine , Amer J Ophthal 58:205-210, 1964. 15. Jones, S.T., and Zimmerman, L.E.: Histopathologic Differentiation of Granular, Macular and Lattice Dystrophies of the Cornea , Amer J Ophthal 51:394-410, 1961. 16. Buschke, W.: Effects of Metabolic Poisons and Some Other Agents on Intercellular Cohesion in Corneal Epithelium , Amer J Ophthal 33:59-66, 1950. 17. Cogan, D.G., and Grant, W.M.: Corneal and Conjunctival Pigmentation Among Workers in Hydroquinone, letter to the editor , Arch Ophthal 38:847, 1947.Crossref 18. Friedmann, E.; Marrian, D.H.; and DimonReuss, J.: Analysis of Antimitotic Action of Certain Quinones , Brit J Pharmacol 3:263-270, 1948.
Archives of Ophthalmology – American Medical Association
Published: Aug 1, 1966
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