Abstract With the increasing use of corneal transplants for therapeutic or functional reasons, the importance of immunological aspects becomes increasingly evident. In this regard perhaps the major problem is the phenomenon of "late clouding." A technically successful, clear graft may frequently become opaque after a period of three to four weeks of perfect transparency. This delayed opacification is the cause of many failures in keratoplasty. There are still many unanswered questions in regard to corneal antigenicity and, in particular, with its relationship to the different anatomical structures of the cornea. The purpose of this study was, therefore, to determine, if possible, the antigenicity of the individual corneal layers separately. As early as 1914, anaphylactic reaction was suggested by Underwood1 as being the cause of the destruction of donor material in a case of skin homotransplants. A similar suggestion was also made by Holman,2 but, in addition, he noticed that References 1. Underwood, H. L.: Anaphylaxis Following Skin-Grafting for Burns , J.A.M.A. 63:775, 1914.Crossref 2. Holman, E.: Protein Sensitization in Isoskin-grafting , Surg. Gynec. & Obst. 38:100, 1924. 3. Medawar, P. B.: Immunity to Homologous Grafted Skin , Brit. J. Exper. Path. 29:58, 1948. 4. Klima, M.: Antigenic Properties of the Corneal Protein , Sborn. Lek. 51:1, 1949 5. abstracted, Excerpta Med. XII 4:280, 1950. 6. Billingham, R. E., and Boswell, T.: Studies on the Problem of Corneal Homografts , Proc. Roy. Soc., London, s. B 141:392, 1953. 7. Maumenee, A. E.: The Influence of Donor-Recipient Sensitization on Corneal Grafts , Am. J. Ophth. 34:142 (May, (Pt. 2) ) 1951. 8. Babel, J., and Bourquin, J. B.: Experimental Research with Corneal Heterografts , Brit. J. Ophth. 36:529, 1952. 9. Basu, P. K., and Ormsby, H. L.: Studies of Immunity with Interlamellar Corneal Homografts in Rabbits , Am. J. Ophth. 44:598 (Nov., (Pt. 1) ) 1957. 10. Dohlman, C. H.: On the Fate of the Corneal Graft , Acta ophth. 35:286, 1957. 11. Smelser, G. K.: The Metabolism of Sulfated Mucopolysaccharides of the Cornea, presented at the 108th Annual Meeting of the American Medical Association, Atlantic City, June 8-12, 1959. 12. Geeraets, W. J.; Lieb, W. A.; Chan, G., and Guerry, D.: Immunochemical Analysis on Heterogenous Corneal Transplants, Am. J. Ophth., to be published. 13. Scheidegger, J. J.: Une Micro-méthode d l' immunoélectrophorèse , Internat. Arch. Allergy 7: 103, 1955. 14. Schutz, J. N.: Dark Field Illuminator for Petri Dish Photography , J. Biol. Photog. A. 26: 159, 1958. 15. Ouchterlony, O.: Antigen-Antibody Reactions in Gels , Acta path. et microbiol. scandinav. 26:507, 1949. 16. Oudin, J.: Specific Precipitation in Gels and Its Application to Immuno-Chemical Analysis , Meth. Med. Res. 5:335, 1952. 17. Geeraets, W. J.; Chan, G., and Guerry, D.: Serum Antibody After Keratoplasty, to be published.
Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1960
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