Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Copper Sulfate-Induced Hemolytic Anemia: Inhibition of Glucose-6-Phosphate Dehydrogenase and Other Possible Etiologic Mechanisms

Copper Sulfate-Induced Hemolytic Anemia: Inhibition of Glucose-6-Phosphate Dehydrogenase and... Abstract Many substances have been found to cause hemolytic anemia in persons whose erythrocytes are deficient in glucose-6-phosphate dehydrogenase (G6PD). However, the basis for the hemolysis observed with heavy metals has not been elucidated. In 1965, the author treated a patient who experienced severe acute hemolytic anemia after accidental ingestion of a saturated solution of copper sulfate. At that time, only one previous report1 of copper sulfate-induced hemolytic anemia in man could be found. Subsequently, two papers2,3 have documented several cases of copper sulfateinduced hemolytic anemia. It also has become apparent that this disorder has been repeatedly recorded in India. The case observed by the author is briefly recorded and investigations of possible mechanisms are described. Report of a Case A 22-year-old white woman inadvertently ingested an unknown amount of saturated copper sulfate solution. She vomited promptly and repeatedly. Diarrhea developed on the same day. Two days later she continued to References 1. Roberts, R.H.: Hemolytic Anemia Associated With Copper Sulfate Poisoning , Mississippi Doctor 33:292-294 ( (March) ) 1956. 2. Chuttani, H.K., et al: Acute Copper Sulfate Poisoning , Amer J Med 39:849-854 ( (Nov) ) 1965.Crossref 3. Holtzman, N.A.; Elliott, D.A.; and Heller, R.H.: Copper Intoxication , New Eng J Med 275:347-352 ( (Aug 18) ) 1966.Crossref 4. Fairbanks, V.F., and Beutler, E.: A Simple Method for Detection of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency (G-6-PD Spot Test) , Blood 20:591-601 ( (Nov) ) 1962. 5. Kornberg, A., and Horecker, B.L.: " Glucose-6-Phosphate Dehydrogenase ," in Colowick, S.P. and Kaplan, N.O. (eds.) Methods in Enzymology : New York: Academic Press, Inc, 1955, vol 1, pp 323-327. 6. Beutler, E.; Duron, O.; and Kelly, B.M.: Improved Method for the Determination of Blood Glutathione , J Lab Clin Med 61:882-888 ( (May) ) 1963. 7. Beutler, E.; Robson, M.J.; and Buttenwieser, E.: The Glutathione Instability of Drug-Sensitive Red Cells , J Lab Clin Med 49:84-95 ( (Jan) ) 1957. 8. Kirkman, H.N.: Glucose 6-Phosphate Dehydrogenase From Human Erythrocytes , J Biol Chem 237:2364-2370 ( (July) ) 1962. 9. Waller, H.D.; Löhr, G.W.; and Gayer, J.: Hereditäre nichtsphä rocytäre hämolytische Anämie durch Glucose-6-phosphatdehydrogenase-Mangel (Bildung eines Enzymproteins mit veränderten Eigenschaften in den Blutzellen eines deutschen Familie.) , Klin Wschr 44:122-128 ( (Feb) ) 1966.Crossref 10. Marks, P.A.; Szeinberg, A.; and Banks, J.: Erythrocyte Glucose 6-Phosphate Dehydrogenase of Normal and Mutant Human Subjects , J Biol Chem 236:10-17 ( (Jan) ) 1961. 11. Webb, J.L.: Enzyme and Metabolic Inhibitors . General Principles of Inhibition , vol 1, New York: Academic Press, Inc., 1963. 12. Mallory, F.B.: Hemochromatosis and Chronic Poisoning With Copper , Arch Intern Med 37: 336-362 ( (March) ) 1926.Crossref 13. Mallory, cited in Flinn, F.B., and Inouye, J.M.: Some Physiological Aspects of Copper in the Organism , J Biol Chem 84:101-114 ( (Oct) ) 1929. 14. Cartwright, G.E., et al: Studies on Copper Metabolism , J Clin Invest 33:1487-1501 ( (Nov) ) 1954.Crossref 15. Davenport, S.: Review of Literature on Health Hazards of Metals : I. Copper, United States Bureau of Mines Information Circular 7666 , United States Department of the Interior, 1953. 16. Beutler, E.: The Hemolytic Effect of Primaquine and Related Compounds: A Review , Blood 14:103-139 ( (Feb) ) 1959. 17. Jacob, H.S., and Jandl, J.H.: Effects of Sulfhydryl Inhibition on Red Blood Cells: II. Studies in Vivo , J Clin Invest 41:1514-1523 ( (July) ) 1962.Crossref 18. Mills, G.C., and Randall, H.P.: Hemoglobin Catabolism , J Biol Chem 232:589-598 ( (June) ) 1958. 19. Jacob, H.S., et al: Oxidative Hemolysis and Erythrocyte Metabolism in Hereditary Acatalasia , J Clin Invest 44:1187-1199 ( (July) ) 1965.Crossref 20. Desforges, J.F.; Kalaw, E., and Gilchrist, P.: Inhibition of Glucose-6-Phosphate Dehydrogenase by Hemolysis Inducing Drugs , J Lab Clin Med 55:757-766 ( (May) ) 1960. 21. Collier, H.B., and Gray, M.W.: Enzyme Inhibition by Derivatives of Phenothiazine , Canad J Biochem 43:105-110 ( (Jan) ) 1965.Crossref 22. Jacob, H.S., and Jandl, J.H.: Effects of Sulfhydryl Inhibition on Red Blood Cells , J Biol Chem 241:4243-4250 ( (Sept 25) ) 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Copper Sulfate-Induced Hemolytic Anemia: Inhibition of Glucose-6-Phosphate Dehydrogenase and Other Possible Etiologic Mechanisms

Archives of Internal Medicine , Volume 120 (4) – Oct 1, 1967

Loading next page...
 
/lp/american-medical-association/copper-sulfate-induced-hemolytic-anemia-inhibition-of-glucose-6-DmP9h5B0FF
Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.04410010042005
Publisher site
See Article on Publisher Site

Abstract

Abstract Many substances have been found to cause hemolytic anemia in persons whose erythrocytes are deficient in glucose-6-phosphate dehydrogenase (G6PD). However, the basis for the hemolysis observed with heavy metals has not been elucidated. In 1965, the author treated a patient who experienced severe acute hemolytic anemia after accidental ingestion of a saturated solution of copper sulfate. At that time, only one previous report1 of copper sulfate-induced hemolytic anemia in man could be found. Subsequently, two papers2,3 have documented several cases of copper sulfateinduced hemolytic anemia. It also has become apparent that this disorder has been repeatedly recorded in India. The case observed by the author is briefly recorded and investigations of possible mechanisms are described. Report of a Case A 22-year-old white woman inadvertently ingested an unknown amount of saturated copper sulfate solution. She vomited promptly and repeatedly. Diarrhea developed on the same day. Two days later she continued to References 1. Roberts, R.H.: Hemolytic Anemia Associated With Copper Sulfate Poisoning , Mississippi Doctor 33:292-294 ( (March) ) 1956. 2. Chuttani, H.K., et al: Acute Copper Sulfate Poisoning , Amer J Med 39:849-854 ( (Nov) ) 1965.Crossref 3. Holtzman, N.A.; Elliott, D.A.; and Heller, R.H.: Copper Intoxication , New Eng J Med 275:347-352 ( (Aug 18) ) 1966.Crossref 4. Fairbanks, V.F., and Beutler, E.: A Simple Method for Detection of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency (G-6-PD Spot Test) , Blood 20:591-601 ( (Nov) ) 1962. 5. Kornberg, A., and Horecker, B.L.: " Glucose-6-Phosphate Dehydrogenase ," in Colowick, S.P. and Kaplan, N.O. (eds.) Methods in Enzymology : New York: Academic Press, Inc, 1955, vol 1, pp 323-327. 6. Beutler, E.; Duron, O.; and Kelly, B.M.: Improved Method for the Determination of Blood Glutathione , J Lab Clin Med 61:882-888 ( (May) ) 1963. 7. Beutler, E.; Robson, M.J.; and Buttenwieser, E.: The Glutathione Instability of Drug-Sensitive Red Cells , J Lab Clin Med 49:84-95 ( (Jan) ) 1957. 8. Kirkman, H.N.: Glucose 6-Phosphate Dehydrogenase From Human Erythrocytes , J Biol Chem 237:2364-2370 ( (July) ) 1962. 9. Waller, H.D.; Löhr, G.W.; and Gayer, J.: Hereditäre nichtsphä rocytäre hämolytische Anämie durch Glucose-6-phosphatdehydrogenase-Mangel (Bildung eines Enzymproteins mit veränderten Eigenschaften in den Blutzellen eines deutschen Familie.) , Klin Wschr 44:122-128 ( (Feb) ) 1966.Crossref 10. Marks, P.A.; Szeinberg, A.; and Banks, J.: Erythrocyte Glucose 6-Phosphate Dehydrogenase of Normal and Mutant Human Subjects , J Biol Chem 236:10-17 ( (Jan) ) 1961. 11. Webb, J.L.: Enzyme and Metabolic Inhibitors . General Principles of Inhibition , vol 1, New York: Academic Press, Inc., 1963. 12. Mallory, F.B.: Hemochromatosis and Chronic Poisoning With Copper , Arch Intern Med 37: 336-362 ( (March) ) 1926.Crossref 13. Mallory, cited in Flinn, F.B., and Inouye, J.M.: Some Physiological Aspects of Copper in the Organism , J Biol Chem 84:101-114 ( (Oct) ) 1929. 14. Cartwright, G.E., et al: Studies on Copper Metabolism , J Clin Invest 33:1487-1501 ( (Nov) ) 1954.Crossref 15. Davenport, S.: Review of Literature on Health Hazards of Metals : I. Copper, United States Bureau of Mines Information Circular 7666 , United States Department of the Interior, 1953. 16. Beutler, E.: The Hemolytic Effect of Primaquine and Related Compounds: A Review , Blood 14:103-139 ( (Feb) ) 1959. 17. Jacob, H.S., and Jandl, J.H.: Effects of Sulfhydryl Inhibition on Red Blood Cells: II. Studies in Vivo , J Clin Invest 41:1514-1523 ( (July) ) 1962.Crossref 18. Mills, G.C., and Randall, H.P.: Hemoglobin Catabolism , J Biol Chem 232:589-598 ( (June) ) 1958. 19. Jacob, H.S., et al: Oxidative Hemolysis and Erythrocyte Metabolism in Hereditary Acatalasia , J Clin Invest 44:1187-1199 ( (July) ) 1965.Crossref 20. Desforges, J.F.; Kalaw, E., and Gilchrist, P.: Inhibition of Glucose-6-Phosphate Dehydrogenase by Hemolysis Inducing Drugs , J Lab Clin Med 55:757-766 ( (May) ) 1960. 21. Collier, H.B., and Gray, M.W.: Enzyme Inhibition by Derivatives of Phenothiazine , Canad J Biochem 43:105-110 ( (Jan) ) 1965.Crossref 22. Jacob, H.S., and Jandl, J.H.: Effects of Sulfhydryl Inhibition on Red Blood Cells , J Biol Chem 241:4243-4250 ( (Sept 25) ) 1966.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1967

References