Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Control of Hepatic Bleeding With Microfibrillar Collagen

Control of Hepatic Bleeding With Microfibrillar Collagen Abstract • Microfibrillar collagen (Avitene) is a new absorbable topical hemostatic agent whose mechanism of action is platelet entrapment and activation of platelet clotting factors. It adheres to moist tissue surfaces to form a firm, flexible hemostatic coagulum. It has been used clinically in 36 patients with hepatic bleeding of diverse etiology, including bleeding from the gallbladder fossa, lacerations, resectional surfaces, biopsy sites, capsular denudations, and hepatic tumors. Although not intended to control major hemorrhage where major vessel ligation or resection is properly indicated, its topical use for diffuse small vessel bleeding may be life-saving. It is exceptionally useful in such conditions as cirrhosis and in thrombocytopenic or thrombasthenic coagulopathies. One treatment failure out of 36 occurred. (Arch Surg 112:941-943, 1977) References 1. Hait MR: Microcrystalline collagen: A new hemostatic agent . Am J Surg 120:330, 1970. 2. Vistnes LM, Goodwin DA, Tenery JH, et al: Control of capillary bleeding by topical application of microcrystalline collagen . Surgery 76:291-294, 1974. 3. Abbott WM, Austen WG: Microcrystalline collagen as a topical hemostatic agent for vascular surgery . Surgery 75:925-933, 1974. 4. Morgenstern L: Microcrystalline collagen used in experimental splenic injury: A new surface hemostatic agent . Arch Surg 109:44-47, 1974.Crossref 5. Lim RC, Lau G, Steele M: Prevention of complications after liver trauma . Am J Surg 132:156-161, 1976.Crossref 6. Defore WW Jr, Mattox KL, Jordan GL Jr, et al: Management of 1,590 consecutive cases of liver trauma . Arch Surg 111:493-497, 1976.Crossref 7. Lucas CE, Ledgerwood AM: Prospective evaluation of hemostatic techniques for liver injuries . J Trauma 16:442-451, 1976.Crossref 8. Zucker WH, Mason RG: Ultrastructural aspects of interactions of platelets with microcrystalline collagen . Am J Pathol 82:129-135, 1976. 9. Abbott WM, Austen WG: The effectiveness and mechanism of collagen-induced topical hemostasis . Surgery 78:723-729, 1975. 10. Hait MR, Robb CA, Baxter CR, et al: Comparative evaluation of Avitene microcrystalline collagen hemostat in experimental animal wounds . Am J Surg 125:284-287, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Control of Hepatic Bleeding With Microfibrillar Collagen

Loading next page...
 
/lp/american-medical-association/control-of-hepatic-bleeding-with-microfibrillar-collagen-mW4z9LsjP7
Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1977.01370080039005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Microfibrillar collagen (Avitene) is a new absorbable topical hemostatic agent whose mechanism of action is platelet entrapment and activation of platelet clotting factors. It adheres to moist tissue surfaces to form a firm, flexible hemostatic coagulum. It has been used clinically in 36 patients with hepatic bleeding of diverse etiology, including bleeding from the gallbladder fossa, lacerations, resectional surfaces, biopsy sites, capsular denudations, and hepatic tumors. Although not intended to control major hemorrhage where major vessel ligation or resection is properly indicated, its topical use for diffuse small vessel bleeding may be life-saving. It is exceptionally useful in such conditions as cirrhosis and in thrombocytopenic or thrombasthenic coagulopathies. One treatment failure out of 36 occurred. (Arch Surg 112:941-943, 1977) References 1. Hait MR: Microcrystalline collagen: A new hemostatic agent . Am J Surg 120:330, 1970. 2. Vistnes LM, Goodwin DA, Tenery JH, et al: Control of capillary bleeding by topical application of microcrystalline collagen . Surgery 76:291-294, 1974. 3. Abbott WM, Austen WG: Microcrystalline collagen as a topical hemostatic agent for vascular surgery . Surgery 75:925-933, 1974. 4. Morgenstern L: Microcrystalline collagen used in experimental splenic injury: A new surface hemostatic agent . Arch Surg 109:44-47, 1974.Crossref 5. Lim RC, Lau G, Steele M: Prevention of complications after liver trauma . Am J Surg 132:156-161, 1976.Crossref 6. Defore WW Jr, Mattox KL, Jordan GL Jr, et al: Management of 1,590 consecutive cases of liver trauma . Arch Surg 111:493-497, 1976.Crossref 7. Lucas CE, Ledgerwood AM: Prospective evaluation of hemostatic techniques for liver injuries . J Trauma 16:442-451, 1976.Crossref 8. Zucker WH, Mason RG: Ultrastructural aspects of interactions of platelets with microcrystalline collagen . Am J Pathol 82:129-135, 1976. 9. Abbott WM, Austen WG: The effectiveness and mechanism of collagen-induced topical hemostasis . Surgery 78:723-729, 1975. 10. Hait MR, Robb CA, Baxter CR, et al: Comparative evaluation of Avitene microcrystalline collagen hemostat in experimental animal wounds . Am J Surg 125:284-287, 1973.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1977

References