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Continuous Phenobarbital Treatment After a 'Simple Febrile Convulsion'

Continuous Phenobarbital Treatment After a 'Simple Febrile Convulsion' Abstract • In only a small proportion of young children with brief, generalized, febrile convulsions do afebrile seizures develop, but this fraction is several times the prevalence of epilepsy in an unselected population. The risk of another febrile convulsion is approximately 30%. Febrile status epilepticus during a subsequent infection is a potential source of serious morbidity and mortality. Intermittent phenobarbital administration during subsequent, febrile illnesses confers little protection against recurrent, febrile convulsions. Continuous phenobarbital administration during the preschool years is indicated for most children who have had a simple febrile convulsion. (Am J Dis Child 132:87-89, 1978) References 1. Livingston S: Comprehensive Management of Epilepsy in Infancy, Childhood, and Adolescence . Springfield, Ill, Charles C Thomas, Publisher, 1972, pp 16-33. 2. Baird HW: Acute or nonrecurrent convulsions , in Vaughan VC, McKay RJ, Nelson WE (eds): Textbook of Pediatrics . Philadelphia, WB Saunders Co, 1975, p 1380. 3. van den Berg BJ, Yerushalmy J: Studies on convulsive disorders in young children: II. Intermittent phenobarbital prophylaxis and recurrence of febrile convulsions . J Pediatr 78:1004-1012, 1971.Crossref 4. Chao D, Carter S, Gold AP: Paroxysmal disorders , in Rudolph AM, Barnett HL, Einhorn AH (eds): Pediatrics , ed 16. New York, Appleton-Century-Crofts Inc, 1977, p 1854. 5. Lennox-Buchthal MA: Febrile convulsions , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . Amsterdam, North Holland Publishing Co, vol 15, 1974. 6. Asnes RS, Novick LF, Nealis J, et al: The first febrile seizure: A study of current pediatric practice . J Pediatr 87:485-488, 1975.Crossref 7. Lennox-Buchthal MA: Febrile Convulsions . Electroencephalogr Neurophysiol , (suppl 32) , 1973. 8. Ouellette E: The child who convulses with fever . Pediatr Clin North Am 21:467-482, 1974. 9. Livingston S: The Diagnosis and Treatment of Convulsive Disorders in Children . Springfield, Ill, Charles C Thomas, Publisher, 1954, pp 76-80. 10. Livingston S: Convulsive disorders in infants and children . Adv Pediatr 10:114-119, 1959. 11. Wallace SJ: Spontaneous fits after convulsions with fever . Arch Dis Child 52:192-196, 1977.Crossref 12. Nelson K, Ellenberg J: Predictors of epilepsy in children who have experienced febrile seizures . New Engl J Med 295:1029-1033, 1976.Crossref 13. Hauser WA, Kurland LT: Incidence, prevalence, time trends of convulsive disorders in Rochester, Minnesota: A community survey , in Alter M, Hauser WA (eds): The Epidemiology of Epilepsy: A Workshop . NINDS Monograph No. 14, 1972. 14. Nelson KB: Febrile seizures , in Swaiman KF, Wright FS (eds): The Practice of Pediatric Neurology . St Louis, CV Mosby Co, 1975, pp 870-874. 15. Ounsted C, Lindsay J, Norman R, et al: Biological Factors in Temporal Lobe Epilepsy . London, William Heinemann Medical Books Ltd, 1966. 16. Falconer MA: Genetic and related aetiological factors in temporal lobe epilepsy: A review . Epilepsia 12:13-31, 1972.Crossref 17. Aicardi J, Chevrie JJ: Convulsive status epilepticus in infants and children . Epilepsia 11:187-197, 1970.Crossref 18. van den Berg BJ: Recurrence of febrile seizures in childhood , in Alter M, Hauser WA (eds): The Epidemiology ofEpilepsy: A Workshop . NINDS Monograph No. 14, 1972. 19. Faero 0, Kastrup KW, Nielsen L, et al: Successful prophylaxis of febrile convulsions with phenobarbital . Epilepsia 13:279-285, 1972.Crossref 20. Dodge PR: Febrile convulsions . J Pediatr 78:1083-1084, 1972. 21. Jailing B: Plasma and cerebrospinal fluid concentrations of phenobarbital in infants given single doses . Dev Med Child Neurol 16:781-793, 1974.Crossref 22. Woodbury DM, Penry JK, Schmidt RP, et al: Antiepileptic Drugs . New York, Raven Press, 1974. 23. Stores G: Behavioral effects of antiepileptic drugs . Dev Med Child Neurol 17:647-658, 1975.Crossref 24. Pippenger CE, Penry JK, White BG, et al: Interlaboratory variability in determination of plasma antiepileptic drug concentrations . Arch Neurol 33:351-355, 1976.Crossref 25. Reynolds EH: Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975.Crossref 26. Melchior JC, Buchthal F, Lennox-Buchthal M, et al: The effectiveness of diphenylhydantoin in preventing febrile convulsions in the age of greatest risk, under 3 years . Epilepsia 12:55-62, 1972.Crossref 27. Cavazutti GB: Prevention of febrile convulsions with dipropylacetate (Depakine) . Epilepsia 16:647-648, 1975.Crossref 28. Wolf SM, Carr A, Davis DC, et al: The value of phenobarbital in the child who has had a single febrile seizure: A controlled prospective study . Pediatrics 59:378-385, 1977. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Continuous Phenobarbital Treatment After a 'Simple Febrile Convulsion'

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120260089021
Publisher site
See Article on Publisher Site

Abstract

Abstract • In only a small proportion of young children with brief, generalized, febrile convulsions do afebrile seizures develop, but this fraction is several times the prevalence of epilepsy in an unselected population. The risk of another febrile convulsion is approximately 30%. Febrile status epilepticus during a subsequent infection is a potential source of serious morbidity and mortality. Intermittent phenobarbital administration during subsequent, febrile illnesses confers little protection against recurrent, febrile convulsions. Continuous phenobarbital administration during the preschool years is indicated for most children who have had a simple febrile convulsion. (Am J Dis Child 132:87-89, 1978) References 1. Livingston S: Comprehensive Management of Epilepsy in Infancy, Childhood, and Adolescence . Springfield, Ill, Charles C Thomas, Publisher, 1972, pp 16-33. 2. Baird HW: Acute or nonrecurrent convulsions , in Vaughan VC, McKay RJ, Nelson WE (eds): Textbook of Pediatrics . Philadelphia, WB Saunders Co, 1975, p 1380. 3. van den Berg BJ, Yerushalmy J: Studies on convulsive disorders in young children: II. Intermittent phenobarbital prophylaxis and recurrence of febrile convulsions . J Pediatr 78:1004-1012, 1971.Crossref 4. Chao D, Carter S, Gold AP: Paroxysmal disorders , in Rudolph AM, Barnett HL, Einhorn AH (eds): Pediatrics , ed 16. New York, Appleton-Century-Crofts Inc, 1977, p 1854. 5. Lennox-Buchthal MA: Febrile convulsions , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . Amsterdam, North Holland Publishing Co, vol 15, 1974. 6. Asnes RS, Novick LF, Nealis J, et al: The first febrile seizure: A study of current pediatric practice . J Pediatr 87:485-488, 1975.Crossref 7. Lennox-Buchthal MA: Febrile Convulsions . Electroencephalogr Neurophysiol , (suppl 32) , 1973. 8. Ouellette E: The child who convulses with fever . Pediatr Clin North Am 21:467-482, 1974. 9. Livingston S: The Diagnosis and Treatment of Convulsive Disorders in Children . Springfield, Ill, Charles C Thomas, Publisher, 1954, pp 76-80. 10. Livingston S: Convulsive disorders in infants and children . Adv Pediatr 10:114-119, 1959. 11. Wallace SJ: Spontaneous fits after convulsions with fever . Arch Dis Child 52:192-196, 1977.Crossref 12. Nelson K, Ellenberg J: Predictors of epilepsy in children who have experienced febrile seizures . New Engl J Med 295:1029-1033, 1976.Crossref 13. Hauser WA, Kurland LT: Incidence, prevalence, time trends of convulsive disorders in Rochester, Minnesota: A community survey , in Alter M, Hauser WA (eds): The Epidemiology of Epilepsy: A Workshop . NINDS Monograph No. 14, 1972. 14. Nelson KB: Febrile seizures , in Swaiman KF, Wright FS (eds): The Practice of Pediatric Neurology . St Louis, CV Mosby Co, 1975, pp 870-874. 15. Ounsted C, Lindsay J, Norman R, et al: Biological Factors in Temporal Lobe Epilepsy . London, William Heinemann Medical Books Ltd, 1966. 16. Falconer MA: Genetic and related aetiological factors in temporal lobe epilepsy: A review . Epilepsia 12:13-31, 1972.Crossref 17. Aicardi J, Chevrie JJ: Convulsive status epilepticus in infants and children . Epilepsia 11:187-197, 1970.Crossref 18. van den Berg BJ: Recurrence of febrile seizures in childhood , in Alter M, Hauser WA (eds): The Epidemiology ofEpilepsy: A Workshop . NINDS Monograph No. 14, 1972. 19. Faero 0, Kastrup KW, Nielsen L, et al: Successful prophylaxis of febrile convulsions with phenobarbital . Epilepsia 13:279-285, 1972.Crossref 20. Dodge PR: Febrile convulsions . J Pediatr 78:1083-1084, 1972. 21. Jailing B: Plasma and cerebrospinal fluid concentrations of phenobarbital in infants given single doses . Dev Med Child Neurol 16:781-793, 1974.Crossref 22. Woodbury DM, Penry JK, Schmidt RP, et al: Antiepileptic Drugs . New York, Raven Press, 1974. 23. Stores G: Behavioral effects of antiepileptic drugs . Dev Med Child Neurol 17:647-658, 1975.Crossref 24. Pippenger CE, Penry JK, White BG, et al: Interlaboratory variability in determination of plasma antiepileptic drug concentrations . Arch Neurol 33:351-355, 1976.Crossref 25. Reynolds EH: Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975.Crossref 26. Melchior JC, Buchthal F, Lennox-Buchthal M, et al: The effectiveness of diphenylhydantoin in preventing febrile convulsions in the age of greatest risk, under 3 years . Epilepsia 12:55-62, 1972.Crossref 27. Cavazutti GB: Prevention of febrile convulsions with dipropylacetate (Depakine) . Epilepsia 16:647-648, 1975.Crossref 28. Wolf SM, Carr A, Davis DC, et al: The value of phenobarbital in the child who has had a single febrile seizure: A controlled prospective study . Pediatrics 59:378-385, 1977.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1978

References