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CONSTANCY OF IRON IN THE BLOOD PLASMA AND URINE IN HEALTH AND IN ANEMIA

CONSTANCY OF IRON IN THE BLOOD PLASMA AND URINE IN HEALTH AND IN ANEMIA Abstract Clinical studies on the production of hemoglobin following the oral administration of iron indicate the physiologic activity of this substance in hypochromic anemia. Heath and his co-workers1 have shown that in such patients the intramuscular injection of ferric ammonium citrate is followed by a rise in hemoglobin representing approximately a quantitative reappearance of the injected iron as hemoglobin. Their observations suggest that the action of iron on the production of hemoglobin is not vaguely "catalytic" but bears a quantitative relationship to the formation of hemoglobin. The interest of investigators is, therefore, logically directed to the question of absorption of iron, since the degree of absorption of a given iron compound obviously controls the amount of iron available for the regeneration of hemoglobin. Unless complete experiments on iron balance are performed, studies of absorption based on the elimination of iron in the feces are profitless. This is due to the References 1. Heath, C. W.; Strauss, M. B., and Castle, W. B.: Quantitative Aspects of Iron Deficiency in Hypochromic Anaemia , J. Clin. Investigation 11:1293, 1932.Crossref 2. Mettier, S. R., and Minot, G. R.: The Effect of Iron on Blood Formation as Influenced by Changing the Acidity of the Gastroduodenal Contents in Certain Cases of Anemia , Am. J. M. Sc. 181:25, 1931.Crossref 3. Riecker, H. H.: Iron Metabolism in Pernicious and in Secondary Anemia , Arch. Int. Med. 46:458 ( (Sept.) ) 1930.Crossref 4. McIntosh, J. F.: The Nonprotein Iron of the Blood , J. Clin. Investigation 12:967, 1933. 5. Henriques, V., and Roland, H.: Zur Frage des Eisenstoffwechsels , Biochem. Ztschr. 201:479, 1928. 6. Bassett, S. H.: Personal communication to the authors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CONSTANCY OF IRON IN THE BLOOD PLASMA AND URINE IN HEALTH AND IN ANEMIA

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Publisher
American Medical Association
Copyright
Copyright © 1934 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1934.00160100073005
Publisher site
See Article on Publisher Site

Abstract

Abstract Clinical studies on the production of hemoglobin following the oral administration of iron indicate the physiologic activity of this substance in hypochromic anemia. Heath and his co-workers1 have shown that in such patients the intramuscular injection of ferric ammonium citrate is followed by a rise in hemoglobin representing approximately a quantitative reappearance of the injected iron as hemoglobin. Their observations suggest that the action of iron on the production of hemoglobin is not vaguely "catalytic" but bears a quantitative relationship to the formation of hemoglobin. The interest of investigators is, therefore, logically directed to the question of absorption of iron, since the degree of absorption of a given iron compound obviously controls the amount of iron available for the regeneration of hemoglobin. Unless complete experiments on iron balance are performed, studies of absorption based on the elimination of iron in the feces are profitless. This is due to the References 1. Heath, C. W.; Strauss, M. B., and Castle, W. B.: Quantitative Aspects of Iron Deficiency in Hypochromic Anaemia , J. Clin. Investigation 11:1293, 1932.Crossref 2. Mettier, S. R., and Minot, G. R.: The Effect of Iron on Blood Formation as Influenced by Changing the Acidity of the Gastroduodenal Contents in Certain Cases of Anemia , Am. J. M. Sc. 181:25, 1931.Crossref 3. Riecker, H. H.: Iron Metabolism in Pernicious and in Secondary Anemia , Arch. Int. Med. 46:458 ( (Sept.) ) 1930.Crossref 4. McIntosh, J. F.: The Nonprotein Iron of the Blood , J. Clin. Investigation 12:967, 1933. 5. Henriques, V., and Roland, H.: Zur Frage des Eisenstoffwechsels , Biochem. Ztschr. 201:479, 1928. 6. Bassett, S. H.: Personal communication to the authors.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1934

References