COMMENTARY Connecting the “Dots” of Brain Dysfunction in Schizophrenia What Does the Picture Look Like? N THIS issue of the lying) process(es) that produce the symptomatic functioning between ARCHIVES, Dr Nancy An- outward appearance that we call these episodes? Is it reasonable to cat- dreasen proposes a “uni- schizophrenia. She supports the well- egorize both of these patients in the tary” neural circuit–cogni- documented argument that, in ex- same diagnostic “bin” called schizo- I tive dysfunction model for ploring the “genetics of schizophre- phrenia? Is it likely that we will find understanding schizophrenia. This nia,” we should rely on “core” a common neural and cognitive dys- commentary will review Andreas- cognitive dysfunctions (ie, interme- function for these seemingly di- en’s scholarly article with a focus on diate phenotypic markers) rather verse states? I believe the odds are (1) the continued search for specific that we will not, because the disor- than on less precise diagnostic crite- 2-4 neural circuit abnormalities in schizo- der is truly heterogeneous, as de- ria. Andreasen notes that on the phrenia and their associated “signa- fined by DSM-IV and by clinicians surface schizophrenia seems to be ture” cognitive deficits; (2) how these and researchers. Unfortunately,
JAMA Psychiatry – American Medical Association
Published: Sep 1, 1999
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