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Congenital Hypopituitarism and Conjugated Hyperbilirubinemia in Two Infants

Congenital Hypopituitarism and Conjugated Hyperbilirubinemia in Two Infants Abstract Congenital hypopituitarism in children is a well-recognized entity.1-10 The association of severe neonatal hypoglycemia with growth hormone or adrenocorticotropin insufficiency and with the presence of a microphallus and cryptorchidism in some of the male patients is well established.6-8 Hepatomegaly and jaundice have been found in some of these patients.8,9 However, the association of hypopituitarism with conjugated hyperbilirubinemia has been previously documented in only one report.10 We have recently encountered two infants with hypopituitarism and hypoglycemia, both of whom also had an increased direct serum bilirubin level. Report of Cases.—Case 1.—This patient was born after 45 weeks' gestation to a 23-year-old para 0 woman by cesarean section for cephalopelvic disproportion. Apgar scores were 3 and 5 at one and five minutes, respectively, for which the infant required oxygen. Physical examination showed a 4.6-kg male infant, 53 cm in length, with polydactyly and microphallus. Stretched length of References 1. Blizzard RM, Alberts M: Hypopituitarism, hypoadrenalism and hypogonadism in the newborn infant . J Pediatr 48:782-792, 1956.Crossref 2. Mosier HD: Hypoplasia of the pituitary and adrenal cortex . J Pediatr 48:633-639, 1956.Crossref 3. Brewer D: Congenital absence of the pituitary gland and its consequences . J Pathol Bacteriol 73:59-67, 1957.Crossref 4. Reid JD: Congenital absence of the pituitary gland . J Pediatr 56:658-664, 1960.Crossref 5. Dunn JM: Anterior pituitary and adrenal absence in a live born normocephalic infant . Am J Obstet Gynecol 96:893-894, 1966. 6. Moncrieff MW, Hill DS, Archer J, et al: Congenital absence of the pituitary gland and adrenal hyperplasia . Arch Dis Child 47:136-137, 1972.Crossref 7. Sadeghi-Nejad A, Senior B: A familial syndrome of isolated "aplasia of the anterior pituitary." J Pediatr 84:79-84, 1974.Crossref 8. Lovinger RD, Kaplan SL, Grumbach MM: Congenital hypopituitarism associated with neonatal hypoglycemia and microphallus: Four cases secondary to hypothalamic hormone deficiencies . J Pediatr 87:1171-1181, 1975.Crossref 9. Johnson JD, Hansen RC, Albritton WL, et al: Hypoplasia of the anterior pituitary and neonatal hypoglycemia . J Pediatr 82:634-641, 1973.Crossref 10. Herman SP, Baggenstoss AH, Cloutier MD: Liver dysfunction and histologic abnormalities in neonatal hypopituitarism . J Pediatr 87:892-895, 1975.Crossref 11. Vanderschueren-Lodeweyckx M, Walter R, Malvaux P, et al: The glucagon stimulation test . J Pediatr 85:182-187, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120340102022
Publisher site
See Article on Publisher Site

Abstract

Abstract Congenital hypopituitarism in children is a well-recognized entity.1-10 The association of severe neonatal hypoglycemia with growth hormone or adrenocorticotropin insufficiency and with the presence of a microphallus and cryptorchidism in some of the male patients is well established.6-8 Hepatomegaly and jaundice have been found in some of these patients.8,9 However, the association of hypopituitarism with conjugated hyperbilirubinemia has been previously documented in only one report.10 We have recently encountered two infants with hypopituitarism and hypoglycemia, both of whom also had an increased direct serum bilirubin level. Report of Cases.—Case 1.—This patient was born after 45 weeks' gestation to a 23-year-old para 0 woman by cesarean section for cephalopelvic disproportion. Apgar scores were 3 and 5 at one and five minutes, respectively, for which the infant required oxygen. Physical examination showed a 4.6-kg male infant, 53 cm in length, with polydactyly and microphallus. Stretched length of References 1. Blizzard RM, Alberts M: Hypopituitarism, hypoadrenalism and hypogonadism in the newborn infant . J Pediatr 48:782-792, 1956.Crossref 2. Mosier HD: Hypoplasia of the pituitary and adrenal cortex . J Pediatr 48:633-639, 1956.Crossref 3. Brewer D: Congenital absence of the pituitary gland and its consequences . J Pathol Bacteriol 73:59-67, 1957.Crossref 4. Reid JD: Congenital absence of the pituitary gland . J Pediatr 56:658-664, 1960.Crossref 5. Dunn JM: Anterior pituitary and adrenal absence in a live born normocephalic infant . Am J Obstet Gynecol 96:893-894, 1966. 6. Moncrieff MW, Hill DS, Archer J, et al: Congenital absence of the pituitary gland and adrenal hyperplasia . Arch Dis Child 47:136-137, 1972.Crossref 7. Sadeghi-Nejad A, Senior B: A familial syndrome of isolated "aplasia of the anterior pituitary." J Pediatr 84:79-84, 1974.Crossref 8. Lovinger RD, Kaplan SL, Grumbach MM: Congenital hypopituitarism associated with neonatal hypoglycemia and microphallus: Four cases secondary to hypothalamic hormone deficiencies . J Pediatr 87:1171-1181, 1975.Crossref 9. Johnson JD, Hansen RC, Albritton WL, et al: Hypoplasia of the anterior pituitary and neonatal hypoglycemia . J Pediatr 82:634-641, 1973.Crossref 10. Herman SP, Baggenstoss AH, Cloutier MD: Liver dysfunction and histologic abnormalities in neonatal hypopituitarism . J Pediatr 87:892-895, 1975.Crossref 11. Vanderschueren-Lodeweyckx M, Walter R, Malvaux P, et al: The glucagon stimulation test . J Pediatr 85:182-187, 1974.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1978

References