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CONGENITAL HEMOLYTIC ICTERUS

CONGENITAL HEMOLYTIC ICTERUS Numerous reports are found in the literature concerning the excellent results obtained with splenectomy in the treatment of familial hemolytic icterus.1 We observed two sisters with familial hemolytic jaundice for sixteen and a half months. During this time frequent examinations of the blood were made. Before splenectomy,2 the increased rate of production of red blood cells and the increased fragility of the red cells, associated with jaundice and a moderate degree of secondary anemia, were consistently present. Immediately following splenectomy, the blood bilirubin and the absolute number of reticulocytes (young red blood cells) returned to normal. REPORT OF CASES Case 1.—History.—On March 16, 1927, the younger sister, aged 5, was brought to the outpatient clinic following an indiscretion in diet. A definite icterus was observed and the abdomen was enlarged and tender. The time when icterus first became evident could not be ascertained. On March 26, 1927, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1929 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1929.01930060131018
Publisher site
See Article on Publisher Site

Abstract

Numerous reports are found in the literature concerning the excellent results obtained with splenectomy in the treatment of familial hemolytic icterus.1 We observed two sisters with familial hemolytic jaundice for sixteen and a half months. During this time frequent examinations of the blood were made. Before splenectomy,2 the increased rate of production of red blood cells and the increased fragility of the red cells, associated with jaundice and a moderate degree of secondary anemia, were consistently present. Immediately following splenectomy, the blood bilirubin and the absolute number of reticulocytes (young red blood cells) returned to normal. REPORT OF CASES Case 1.—History.—On March 16, 1927, the younger sister, aged 5, was brought to the outpatient clinic following an indiscretion in diet. A definite icterus was observed and the abdomen was enlarged and tender. The time when icterus first became evident could not be ascertained. On March 26, 1927, the

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jun 1, 1929

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