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CONGENITAL FAMILIAL EXTERNAL OPHTHALMOPLEGIA WITHOUT PTOSIS: WITH A LESION OF THE PYRAMIDAL TRACT

CONGENITAL FAMILIAL EXTERNAL OPHTHALMOPLEGIA WITHOUT PTOSIS: WITH A LESION OF THE PYRAMIDAL TRACT Abstract Congenital disturbances of the ocular muscles occur in the following order of frequency: (a) ptosis, (b) paralysis of the abducens nerve with or without involvement of the facial nerve and (c) complete or incomplete involvement of the third nerve with ptosis. Congenital familial external ophthalmoplegia without ptosis is rare.1 A case of this anomaly associated with involvement of the right side of the pyramidal tract is reported. The interest in this case lies not only in the rarity of the condition but in the clinical data, which point to a better understanding of the etiology of such anomalies. A. H., a woman aged 22, was admitted to the neurologic clinic of the New York Post-Graduate Medical School and Hospital complaining of "nervousness," a feeling of tension and "generalized fatigability." The family history revealed that the patient's grandmother was supposed to have been afflicted with "eye trouble." Persons would remark References 1. Ulrich, O., in Bumke, O., and Foerster, O.: Handbuch der Neurologie , Berlin, Julius Springer, 1933, vol. 16, p. 145. 2. Oppenheim, H.: Text-Book of Nervous Diseases , ed. 5, translated by A. Bruce, New York, G. E. Stechart & Co., 1911, vol. 2, p. 1041. 3. Bernheimer, S.: Aetiologie und pathologischen Anatomie der Augenmuskellähmungen , in von Graefe, A., and Saemisch, T.: Handbuch der gesamten Augenheilkunde , Leipzig, Wilhelm Engelmann, 1907, p. 34. 4. Langdon, H. W., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia , Brain 51:321, 1928.Crossref 5. Mobius, P. J.: Ueber infantilen Kernschwund, München , med. Wchnschr. 39:17 ( (Jan. 12) ) 1892. 6. Li, T. M.: Congenital Total Bilateral Ophthalmoplegia , Am. J. Ophth. 6:817, 1928. 7. Spatz, H., and Ullrich, O.: Klinischer und anatomischer Beitrag zu den angenborenen Beweglichkeitsdefekten im Hirnnervenbereich , Ztschr. f. Kinderh. 51:579, 1931.Crossref 8. Gourfein, D.: Un cas de double ophthalmoplegie extérieure congénitale et hereditaire chez six membres de la même famille , Rev. méd. de la Suisse Rom. 16:673, 1896. 9. Bradburne, A. A.: Hereditary Ophthalmoplegia in Five Generations , Tr. Ophth. Soc. U. Kingdom 32:142, 1912. 10. Lawford, J. B.: Congenital Hereditary Defect of Ocular Movements , Tr. Ophth. Soc. U. Kingdom 8:262, 1888. 11. Fuchs, E.: Ueber isolierte doppelseitige Ptosis , Arch. f. Ophth. 36:234, 1890. 12. de Schweinitz, G. E.: Complete Bilateral Congenital Exterior Ophthalmoplegia and Double Ptosis ; Bilateral Cerebral Cortical Atrophy of the Frontal and Parietal Regions (Encephalograms) ; Clinical Communication , Arch. Ophth. 5:15 ( (Jan.) ) 1931.Crossref 13. Zappert, J.: Ueber infantilen Kernschwund , Ergebn. d. inn. Med. u. Kinderh. 5:305, 1910. 14. Vogt, O.: Der Begriff der Pathoklise , J. f. Psychol. u. Neurol. 31:245, 1925. 15. Bauman, G. I.: Absence of the Cervical Spine: Klippel-Feil Syndrome , J. A. M. A. 98:129 ( (Jan. 9) ) 1932.Crossref 16. Bagg, H. J.: Disturbances in Mammalian Development Produced by Radium Emanation , Am. J. Anat. 30:133, 1922.Crossref 17. Bagg, H. J., and Little, C. C. : Hereditary Structural Defects in the Descendants of Mice Exposed to Roentgen-Ray Irradiation , Am. J. Anat. 33:119, 1924.Crossref 18. Keegan, J. J. : Comparative Study of the Roof of the Fourth Ventricle , Anat. Rec. 2:379, 1917. 19. Bennevi, K. : Embryological Analysis of Gene Manifestations in Little and Bagg's Abnormal Mouse Tribe , J. Exper. Zoöl. 67:443, 1934.Crossref 20. Weed, L. H. : The Development of the Cerebrospinal Spaces in Pig and in Man , Publication 225, Carnegie Institution of Washington, 1917. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

CONGENITAL FAMILIAL EXTERNAL OPHTHALMOPLEGIA WITHOUT PTOSIS: WITH A LESION OF THE PYRAMIDAL TRACT

Archives of Ophthalmology , Volume 21 (5) – May 1, 1939

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1939.00860050107008
Publisher site
See Article on Publisher Site

Abstract

Abstract Congenital disturbances of the ocular muscles occur in the following order of frequency: (a) ptosis, (b) paralysis of the abducens nerve with or without involvement of the facial nerve and (c) complete or incomplete involvement of the third nerve with ptosis. Congenital familial external ophthalmoplegia without ptosis is rare.1 A case of this anomaly associated with involvement of the right side of the pyramidal tract is reported. The interest in this case lies not only in the rarity of the condition but in the clinical data, which point to a better understanding of the etiology of such anomalies. A. H., a woman aged 22, was admitted to the neurologic clinic of the New York Post-Graduate Medical School and Hospital complaining of "nervousness," a feeling of tension and "generalized fatigability." The family history revealed that the patient's grandmother was supposed to have been afflicted with "eye trouble." Persons would remark References 1. Ulrich, O., in Bumke, O., and Foerster, O.: Handbuch der Neurologie , Berlin, Julius Springer, 1933, vol. 16, p. 145. 2. Oppenheim, H.: Text-Book of Nervous Diseases , ed. 5, translated by A. Bruce, New York, G. E. Stechart & Co., 1911, vol. 2, p. 1041. 3. Bernheimer, S.: Aetiologie und pathologischen Anatomie der Augenmuskellähmungen , in von Graefe, A., and Saemisch, T.: Handbuch der gesamten Augenheilkunde , Leipzig, Wilhelm Engelmann, 1907, p. 34. 4. Langdon, H. W., and Cadwalader, W. B.: Chronic Progressive External Ophthalmoplegia , Brain 51:321, 1928.Crossref 5. Mobius, P. J.: Ueber infantilen Kernschwund, München , med. Wchnschr. 39:17 ( (Jan. 12) ) 1892. 6. Li, T. M.: Congenital Total Bilateral Ophthalmoplegia , Am. J. Ophth. 6:817, 1928. 7. Spatz, H., and Ullrich, O.: Klinischer und anatomischer Beitrag zu den angenborenen Beweglichkeitsdefekten im Hirnnervenbereich , Ztschr. f. Kinderh. 51:579, 1931.Crossref 8. Gourfein, D.: Un cas de double ophthalmoplegie extérieure congénitale et hereditaire chez six membres de la même famille , Rev. méd. de la Suisse Rom. 16:673, 1896. 9. Bradburne, A. A.: Hereditary Ophthalmoplegia in Five Generations , Tr. Ophth. Soc. U. Kingdom 32:142, 1912. 10. Lawford, J. B.: Congenital Hereditary Defect of Ocular Movements , Tr. Ophth. Soc. U. Kingdom 8:262, 1888. 11. Fuchs, E.: Ueber isolierte doppelseitige Ptosis , Arch. f. Ophth. 36:234, 1890. 12. de Schweinitz, G. E.: Complete Bilateral Congenital Exterior Ophthalmoplegia and Double Ptosis ; Bilateral Cerebral Cortical Atrophy of the Frontal and Parietal Regions (Encephalograms) ; Clinical Communication , Arch. Ophth. 5:15 ( (Jan.) ) 1931.Crossref 13. Zappert, J.: Ueber infantilen Kernschwund , Ergebn. d. inn. Med. u. Kinderh. 5:305, 1910. 14. Vogt, O.: Der Begriff der Pathoklise , J. f. Psychol. u. Neurol. 31:245, 1925. 15. Bauman, G. I.: Absence of the Cervical Spine: Klippel-Feil Syndrome , J. A. M. A. 98:129 ( (Jan. 9) ) 1932.Crossref 16. Bagg, H. J.: Disturbances in Mammalian Development Produced by Radium Emanation , Am. J. Anat. 30:133, 1922.Crossref 17. Bagg, H. J., and Little, C. C. : Hereditary Structural Defects in the Descendants of Mice Exposed to Roentgen-Ray Irradiation , Am. J. Anat. 33:119, 1924.Crossref 18. Keegan, J. J. : Comparative Study of the Roof of the Fourth Ventricle , Anat. Rec. 2:379, 1917. 19. Bennevi, K. : Embryological Analysis of Gene Manifestations in Little and Bagg's Abnormal Mouse Tribe , J. Exper. Zoöl. 67:443, 1934.Crossref 20. Weed, L. H. : The Development of the Cerebrospinal Spaces in Pig and in Man , Publication 225, Carnegie Institution of Washington, 1917.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1939

References

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