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Congenital Cytomegalovirus Infection Associated With Multicystic Kidney

Congenital Cytomegalovirus Infection Associated With Multicystic Kidney Abstract THE SPECTRUM of disease caused by congenital cytomegalovirus infection is gradually being expanded beyond the classic combination of hepatosplenomegaly, thrombocytopenia, and microcephaly.1 Milder forms of congenital infection have been described,2-4 and it is possible that some infants born infected will be totally asymptomatic. Recent surveys indicate that 1% to 2% of ostensibly normal infants carry cytomegalovirus at birth.5 Since follow-up studies of these infected but asymptomatic infants have not yet been reported, the pathogenicity of the virus in these cases is uncertain. The case report that follows concerns a newborn infant with undoubted cytomegalovirus infection, who also had a cystic horseshoe kidney. Speculation concerning the relationship of the two findings is presented. Report of a Case The patient is a male first-born child. No unusual incidents or minor illnesses occurred during the pregnancy of his mother who was 32 years of age. Labor and delivery were normal. References 1. Weller, T.H., and Hanshaw, J.B.: Virologic and Clinical Observation on Cytomegalic Inclusion Disease , New Eng J Med 266:1233-1244 ( (June 14) ) 1962.Crossref 2. Emanuel, I., and Kenny, G.E.: Cytomegalic Inclusion Disease of Infancy , Pediatrics 38:957-965 ( (Dec) ) 1966. 3. Benyesh-Melnick, M.; Rosenberg, H.S.; and Watson, B.: Viruses in Cell Cultures of Kidneys of Children With Congenital Heart Malformations and Other Diseases , Proc Soc Exp Biol Med 117:452-459 ( (Nov) ) 1964.Crossref 4. Hanshaw, J.B.: Congenital and Acquired Cytomegalovirus Infection , Pediat Clin N Amer 13:279-293 ( (March) ) 1966. 5. Hanshaw, J.B.; Steinfeld, H.J.; and White, C.J.: Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin , abstracted, New Eng J Med 279:566-570 ( (Sept 12) ) 1968.Crossref 6. Stern, H., and Tucker, S.M.: Cytomegalovirus Infection in the Newborn and in Early Childhood , Lancet 2:1268-1271 ( (Dec 18) ) 1965.Crossref 7. Lang, D.J.: The Association of Indirect Inguinal Hernia With Congenital Cytomegalic Inclusion Disease , Pediatrics 38:913-916 ( (Nov) ) 1966. 8. Bradford, W.D., et al: Cystic Disease of Liver and Kidney With Portal Hypertension: A Cause of Sudden Unexpected Hematemesis , Clin Pediat 7:299-306 ( (March) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Congenital Cytomegalovirus Infection Associated With Multicystic Kidney

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040517018
Publisher site
See Article on Publisher Site

Abstract

Abstract THE SPECTRUM of disease caused by congenital cytomegalovirus infection is gradually being expanded beyond the classic combination of hepatosplenomegaly, thrombocytopenia, and microcephaly.1 Milder forms of congenital infection have been described,2-4 and it is possible that some infants born infected will be totally asymptomatic. Recent surveys indicate that 1% to 2% of ostensibly normal infants carry cytomegalovirus at birth.5 Since follow-up studies of these infected but asymptomatic infants have not yet been reported, the pathogenicity of the virus in these cases is uncertain. The case report that follows concerns a newborn infant with undoubted cytomegalovirus infection, who also had a cystic horseshoe kidney. Speculation concerning the relationship of the two findings is presented. Report of a Case The patient is a male first-born child. No unusual incidents or minor illnesses occurred during the pregnancy of his mother who was 32 years of age. Labor and delivery were normal. References 1. Weller, T.H., and Hanshaw, J.B.: Virologic and Clinical Observation on Cytomegalic Inclusion Disease , New Eng J Med 266:1233-1244 ( (June 14) ) 1962.Crossref 2. Emanuel, I., and Kenny, G.E.: Cytomegalic Inclusion Disease of Infancy , Pediatrics 38:957-965 ( (Dec) ) 1966. 3. Benyesh-Melnick, M.; Rosenberg, H.S.; and Watson, B.: Viruses in Cell Cultures of Kidneys of Children With Congenital Heart Malformations and Other Diseases , Proc Soc Exp Biol Med 117:452-459 ( (Nov) ) 1964.Crossref 4. Hanshaw, J.B.: Congenital and Acquired Cytomegalovirus Infection , Pediat Clin N Amer 13:279-293 ( (March) ) 1966. 5. Hanshaw, J.B.; Steinfeld, H.J.; and White, C.J.: Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin , abstracted, New Eng J Med 279:566-570 ( (Sept 12) ) 1968.Crossref 6. Stern, H., and Tucker, S.M.: Cytomegalovirus Infection in the Newborn and in Early Childhood , Lancet 2:1268-1271 ( (Dec 18) ) 1965.Crossref 7. Lang, D.J.: The Association of Indirect Inguinal Hernia With Congenital Cytomegalic Inclusion Disease , Pediatrics 38:913-916 ( (Nov) ) 1966. 8. Bradford, W.D., et al: Cystic Disease of Liver and Kidney With Portal Hypertension: A Cause of Sudden Unexpected Hematemesis , Clin Pediat 7:299-306 ( (March) ) 1968.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1969

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