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Concurrence of Iris Aneurysms and Cerebral Hemorrhage in Hypertensive Rabbits

Concurrence of Iris Aneurysms and Cerebral Hemorrhage in Hypertensive Rabbits Abstract • The development of miliary aneurysms of the iris is associated with the high risk of cerebral hemorrhage in rabbits with renal hypertension. The high-risk group of hypertensive rabbits in this series was characterized by the formation of iris aneurysms, and this group developed a striking proportion of hemorrhagic strokes (42.5%). In the low-risk group of hypertensive rabbits that did not develop aneurysms of the iris, only a low proportion of cerebral hemorrhages were found (11%). The development of iris aneurysms in rabbits was directly proportional to increments in level of blood pressure, and their rate of formation was very rapid. The formation of miliary aneurysms of the circular artery of the iris in hypertensive rabbits is likely related to the common embryologic origin and the morphologic similarity between perforating arteries of the brain and the principal arterial vessel of the iris. References 1. Santos-Buch CA: The experimental production of Charcot-Bouchard miliary arterial aneurysms and strokes in hypertensive rabbits, abstracted . Stroke 4:334, 1973. 2. Santos-Buch CA, Goodhue WW Jr, Ewald BH: Experimental production of miliary aneurysms with hypertension, in Whisnant JP, Sandok BA (eds): Transactions of the Ninth Princeton Conference on Cerebral Vascular Disease. New York, Grune & Stratton Inc, 1975, p 91. 3. Santos-Buch CA: Extrusion of ATP-ase activity from pinocytotic vesicles of abutting endothelium and smooth muscle to the internal elastic membrane of the major arterial circle of the iris of rabbits . Nature 211:600-602, 1966.Crossref 4. Charcot JM, Bouchard C: Nouvelles Récherches sur la pathogenie de l'hemorrhagic cérébrale . Arch Physiol Normal Pathol 1:110-127, 643-645, 1868. 5. Campbell WG Jr, Santos-Buch CA: Widely distributed necrotizing arteritis induced in rabbits by experimental renal alterations: I. Comparison with the vascular lesions induced by injections of horse serum . Am J Pathol 35:439-465, 1959. 6. Campbell WG Jr, Santos-Buch CA: Widely distributed necrotizing arteritis induced in rabbits by experimental renal alterations: III. Studies on activity and decay of necrotizing factors . Am J Pathol 43:131-141, 1963. 7. Santos-Buch CA, Murphy GE, Becker CG, et al: Evidence of a causative role of adrenocortical activity in the genesis of disseminated necrotizing arterial lesions induced in rabbits by renal alterations . Lab Invest 15:1327-1341, 1966. 8. Lowry OH, Roberts NR, Schulz DW, et al: Quantitative histochemistry of the retina: II. Enzymes of glucose metabolism . J Biol Chem 236:2813-2820, 1961. 9. Fisher MC: Cerebral miliary aneurysms in hypertension . Am J Pathol 66:313-324, 1971. 10. Ikeda M, Fujii J, Teresawa F, et al: Cerebral hemorrhage in experimental renal hypertension . Jap Heart J 5:466-473, 1964.Crossref 11. Brunner HR, Laragh JH, Baer L, et al: Essential hypertension: Renin and aldosterone, heart attack and stroke . N Engl J Med 286:441-449, 1971.Crossref 12. Virchow R: Ueber die Erweiterung Kleinerer Gefässe . Virchows Arch Anat Klin Med 3:427-462, 1851.Crossref 13. Heschl H: Die Capillar-Aneurysmen im Pons Variollii . Wien Med Wochenschr 15:1285-1292, 1314-1330, 1855. 14. Gull WW: Cases of aneurism of the cerebral vessels . Guys Hosp Rep 5:281-304, 1859. 15. Ellis AG: The pathogenesis of spontaneous cerebral hemorrhage . Proc Pathol Soc Philadelphia 12:197-235, 1909. 16. Pick L: Ueber die sogenannten miliaren Aneurysmen der Hirngefässe . Berl Klin Wochenschr 47:325-340, 1910. 17. Schwartz P: Cerebral Apoplexy: Types, Causes and Pathogenesis . Springfield, Ill, Charles C Thomas Publisher, 1961. 18. Green FH: Miliary aneurysms in the brain . J Pathol Bacteriol 33:71-77, 1930.Crossref 19. Russell RW: Observations on intracerebral aneurysms . Brain 86:425-442, 1963.Crossref 20. Dinsdale HB: Spontaneous hemorrhage in the posterior fossa: A study of primary cerebellar and pontine hemorrhages with observations on their pathogenesis . Arch Neurol 10:200-218, 1964.Crossref 21. Cole FM, Yates DP: The occurrence and significance of intracerebral microaneurysms . J Pathol Bacteriol 93:393-411, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Concurrence of Iris Aneurysms and Cerebral Hemorrhage in Hypertensive Rabbits

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1976.00500020024005
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Abstract

Abstract • The development of miliary aneurysms of the iris is associated with the high risk of cerebral hemorrhage in rabbits with renal hypertension. The high-risk group of hypertensive rabbits in this series was characterized by the formation of iris aneurysms, and this group developed a striking proportion of hemorrhagic strokes (42.5%). In the low-risk group of hypertensive rabbits that did not develop aneurysms of the iris, only a low proportion of cerebral hemorrhages were found (11%). The development of iris aneurysms in rabbits was directly proportional to increments in level of blood pressure, and their rate of formation was very rapid. The formation of miliary aneurysms of the circular artery of the iris in hypertensive rabbits is likely related to the common embryologic origin and the morphologic similarity between perforating arteries of the brain and the principal arterial vessel of the iris. References 1. Santos-Buch CA: The experimental production of Charcot-Bouchard miliary arterial aneurysms and strokes in hypertensive rabbits, abstracted . Stroke 4:334, 1973. 2. Santos-Buch CA, Goodhue WW Jr, Ewald BH: Experimental production of miliary aneurysms with hypertension, in Whisnant JP, Sandok BA (eds): Transactions of the Ninth Princeton Conference on Cerebral Vascular Disease. New York, Grune & Stratton Inc, 1975, p 91. 3. Santos-Buch CA: Extrusion of ATP-ase activity from pinocytotic vesicles of abutting endothelium and smooth muscle to the internal elastic membrane of the major arterial circle of the iris of rabbits . Nature 211:600-602, 1966.Crossref 4. Charcot JM, Bouchard C: Nouvelles Récherches sur la pathogenie de l'hemorrhagic cérébrale . Arch Physiol Normal Pathol 1:110-127, 643-645, 1868. 5. Campbell WG Jr, Santos-Buch CA: Widely distributed necrotizing arteritis induced in rabbits by experimental renal alterations: I. Comparison with the vascular lesions induced by injections of horse serum . Am J Pathol 35:439-465, 1959. 6. Campbell WG Jr, Santos-Buch CA: Widely distributed necrotizing arteritis induced in rabbits by experimental renal alterations: III. Studies on activity and decay of necrotizing factors . Am J Pathol 43:131-141, 1963. 7. Santos-Buch CA, Murphy GE, Becker CG, et al: Evidence of a causative role of adrenocortical activity in the genesis of disseminated necrotizing arterial lesions induced in rabbits by renal alterations . Lab Invest 15:1327-1341, 1966. 8. Lowry OH, Roberts NR, Schulz DW, et al: Quantitative histochemistry of the retina: II. Enzymes of glucose metabolism . J Biol Chem 236:2813-2820, 1961. 9. Fisher MC: Cerebral miliary aneurysms in hypertension . Am J Pathol 66:313-324, 1971. 10. Ikeda M, Fujii J, Teresawa F, et al: Cerebral hemorrhage in experimental renal hypertension . Jap Heart J 5:466-473, 1964.Crossref 11. Brunner HR, Laragh JH, Baer L, et al: Essential hypertension: Renin and aldosterone, heart attack and stroke . N Engl J Med 286:441-449, 1971.Crossref 12. Virchow R: Ueber die Erweiterung Kleinerer Gefässe . Virchows Arch Anat Klin Med 3:427-462, 1851.Crossref 13. Heschl H: Die Capillar-Aneurysmen im Pons Variollii . Wien Med Wochenschr 15:1285-1292, 1314-1330, 1855. 14. Gull WW: Cases of aneurism of the cerebral vessels . Guys Hosp Rep 5:281-304, 1859. 15. Ellis AG: The pathogenesis of spontaneous cerebral hemorrhage . Proc Pathol Soc Philadelphia 12:197-235, 1909. 16. Pick L: Ueber die sogenannten miliaren Aneurysmen der Hirngefässe . Berl Klin Wochenschr 47:325-340, 1910. 17. Schwartz P: Cerebral Apoplexy: Types, Causes and Pathogenesis . Springfield, Ill, Charles C Thomas Publisher, 1961. 18. Green FH: Miliary aneurysms in the brain . J Pathol Bacteriol 33:71-77, 1930.Crossref 19. Russell RW: Observations on intracerebral aneurysms . Brain 86:425-442, 1963.Crossref 20. Dinsdale HB: Spontaneous hemorrhage in the posterior fossa: A study of primary cerebellar and pontine hemorrhages with observations on their pathogenesis . Arch Neurol 10:200-218, 1964.Crossref 21. Cole FM, Yates DP: The occurrence and significance of intracerebral microaneurysms . J Pathol Bacteriol 93:393-411, 1967.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Feb 1, 1976

References